The study provides a framework and research agenda for investigating factors that contribute to the sustainability and growth of entrepreneurial ventures operating in environments of regime change. The suggested framework builds on Herbert Simon’s [1] science of design, as later extended to concepts of entrepreneurship as creation [2] and effectuation [3], in order to describe the nature of entrepreneurial actions in an environment of regime change. The framework integrates theory on organizational capabilities [4] to locate mechanisms behind entrepreneurs’ successful efforts to equip their ventures with capabilities for sustainability and growth. The study offers a pragmatism-driven methodology for studying ventures as artifacts created by entrepreneurs that practice the even-if principle of non-predictable control when navigating the challenges of regime change.