Social behaviors and acoustic vocalizations in different strains of mice

Faure, Alexis; Pittaras, Elsa; Nosjean, Anne; Chabout, Jonathan; Cressant, Arnaud; Granon, Sylvie

doi:10.1016/j.bbr.2016.11.003

Cited by 35 publications

(33 citation statements)

References 35 publications

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“…The rank‐order differences in sociability between the B6 and D2 strains are independent of testing the B6 strain with a same‐ or different‐strain partner, yet are more robust in the DSI compared with the 3‐chamber task (Figure S1). Previous studies examining social behavior in adult dyads have provided mixed evidence of higher sociability in the D2 compared with the B6 strain . Because these strains show differences in anxiety and aggression, we suggest that variation in strain differences in sociability across studies and tasks are likely due to features of the task and social partner (eg, familiarity of the testing environment, partner age) that differentially elicit affiliative, anxious, or aggressive behaviors.…”

Section: Discussionmentioning

confidence: 65%

“…Previous studies examining social behavior in adult dyads have provided mixed evidence of higher sociability in the D2 compared with the B6 strain. 9,51,56,91,110,111 Because these strains show differences in anxiety and aggression, 56,91,110,112,113 we suggest that variation in strain differences in sociability across studies and tasks are likely due to features of the task and social partner (eg, familiarity of the testing environment, partner age) that differentially elicit affiliative, anxious, or aggressive behaviors.…”

Section: Discussionmentioning

confidence: 89%

“…Mice are particularly advantageous for examining the genetic architecture of sociability because of their high levels and lifelong expression of affiliative behaviors . Outbred and unrelated‐inbred mouse strains show differences in affiliative and aggressive social behavior and mutant mice have been the focus of numerous candidate gene studies …”

Section: Introductionmentioning

confidence: 99%

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Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co‐occurring traits

Knoll

Jiang

Levitt

2017

Genes Brain and Behavior

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Humans exhibit broad heterogeneity in affiliative social behavior. Twin and family studies show that individual differences in core dimensions of social behavior are heritable, yet there are knowledge gaps in understanding the underlying genetic and neurobiological mechanisms. Animal genetic reference panels (GRPs) provide a tractable strategy for examining the behavioral and genetic architecture of complex traits. Here, using males from 50 mouse strains from the BXD GRP, 4 domains of affiliative social behavior—social approach, social recognition, direct social interaction (DSI) (partner sniffing) and vocal communication—were examined in 2 widely used behavioral tasks—the 3‐chamber and DSI tasks. There was continuous and broad variation in social and nonsocial traits, with moderate to high heritability of social approach sniff preference (0.31), ultrasonic vocalization (USV) count (0.39), partner sniffing (0.51), locomotor activity (0.54‐0.66) and anxiety‐like behavior (0.36). Principal component analysis shows that variation in social and nonsocial traits are attributable to 5 independent factors. Genome‐wide mapping identified significant quantitative trait loci for USV count on chromosome (Chr) 18 and locomotor activity on Chr X, with suggestive loci and candidate quantitative trait genes identified for all traits with one notable exception—partner sniffing in the DSI task. The results show heritable variation in sociability, which is independent of variation in activity and anxiety‐like traits. In addition, a highly heritable and ethological domain of affiliative sociability—partner sniffing—appears highly polygenic. These findings establish a basis for identifying functional natural variants, leading to a new understanding typical and atypical sociability.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co‐occurring traits

Knoll

Jiang

Levitt

2017

Genes Brain and Behavior

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“…We have investigated whether various behavioral reactions of different out-group demonstrator strains to foot shocks (ie, jumping, freezing, running or vocalization) can trigger the differential level of vicarious freezing in observer mice. Despite potential difference in demonstrator's vocalization or social cues between different inbred strains, 44,45 we found that C57BL/6 J (B6J) male observer mice exhibited similar levels of observational fear toward different out-group FVB/NJ and 129S1/SvImJ demonstrator strains. 37 If demonstrator's vocalization or social cues differed between the mice of these three inbred strains, these differences did not significantly determine the degree of vicarious fear expressed by the B6J observer mice.…”

Section: Sensory Modalities: Sound/vocalization/visionmentioning

confidence: 71%

Observational fear behavior in rodents as a model for empathy

Kim

Keum

Shin

2018

Genes Brain and Behavior

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Empathy enables social mammals to recognize and share emotion with others and is well‐documented in non‐human primates. During the past few years, systematic observations have showed that a primal form of empathy also exists in rodents, indicating that empathy has an evolutionary continuity. Now, using rodents exhibiting emotional empathy, the molecular and cellular study of empathy in animals has begun in earnest. In this article, we will review recent reports that indicate that rodents can share states of fear with others, and will try to highlight new understandings of the neural circuitry, biochemistry and genetics of empathic fear. We hope that the use of rodent models will enhance understanding of the mechanisms of human empathy and provide insights into how to treat social deficits in neuropsychiatric disorders characterized by empathy impairment.

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“…Inbred mouse lines widely differ in ultrasonic vocalization (Faure et al, 2017; Scattoni et al, 2008; Scattoni, Ricceri, & Crawley, 2011). Mouse models are maintained using various breeding methods.…”

Section: Commentarymentioning

confidence: 99%

Computational Analysis of Neonatal Mouse Ultrasonic Vocalization

et al. 2018

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Neonatal vocalization is structurally altered in mouse models of autism spectrum disorder (ASD). Our published data showed that pup vocalization, under conditions of maternal separation, contains sequences whose alterations in a genetic mouse model of ASD impair social communication between pups and mothers. We describe details of a method which reveals the statistical structure of call sequences that are functionally critical for optimal maternal care. Entropy analysis determines the degree of non-random call sequencing. A Markov model determines the actual call sequences used by pups. Sparse partial least squares discriminant analysis (sPLS-DA) identifies call sequences that differentiate groups and reveals the degrees of individual variability in call sequences between groups. These three sets of analyses can be used to identify the otherwise hidden call structure that is altered in mouse models of developmental neuropsychiatric disorders, including not only autism but also schizophrenia. © 2018 by John Wiley & Sons, Inc.

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Social behaviors and acoustic vocalizations in different strains of mice

Cited by 35 publications

References 35 publications

Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co‐occurring traits

Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co‐occurring traits

Observational fear behavior in rodents as a model for empathy

Computational Analysis of Neonatal Mouse Ultrasonic Vocalization

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