Social and novel contexts modify hippocampal CA2 representations of space

Alexander, Georgia M.; Farris, Shannon; Pirone, Jason R.; Zheng, Chenguang; Colgin, Laura Lee; Dudek, Serena M.

doi:10.1038/ncomms10300

Cited by 163 publications

(207 citation statements)

References 62 publications

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“…77)—recent data seem to indicate that CA2 may be especially important for temporal 78 and social 79–81 memory. There is not nearly enough data on CA2, and it will be important to know the extent to which the representational scheme in CA2 parallels the more well-known subfields.…”

Section: Do Hippocampal Pyramidal Cells Reliably Encode Nonspatial Inmentioning

confidence: 99%

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

et al. 2017

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The hippocampus serves a critical function in memory, navigation, and cognition. Nature Neuroscience asked John Lisman to lead a group of researchers in a dialog on shared and distinct viewpoints on the hippocampus. There has been a long history of studying the hippocampus, but recent work has made it possible to study the cellular and network basis of defined operations—operations that include cognitive processes that have been otherwise difficult to study (see Box 1 for useful terminology). These operations deal with the context-dependent representation of complex memories, the role of mental exploration based on imagined rather than real movements, and the use of recalled information for navigation and decision-making. The progress that has been made in understanding the hippocampus has motivated the study of other brain regions that provide hippocampal input or receive hippocampal output; the hippocampus is thus serving as a nucleating point for the larger goal of understanding the neural codes that allow inter-regional communication and more generally, understanding how memory-guided behavior is achieved by large scale integration of brain regions. In generating a discussion among experts in the study of the cognitive processes of the hippocampus, the editors and I have posed questions that probe important principles of hippocampal function. We hope that the resulting discussion will make clear to readers the progress that has been made, while also identifying issues where consensus has not yet been achieved and that should be pursued in future research. – John Lisman

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Section: Do Hippocampal Pyramidal Cells Reliably Encode Nonspatial Inmentioning

confidence: 99%

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

et al. 2017

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“…85). CA2 neurons also had a higher mean firing rate than CA1 and CA3 neurons 30,85 . Together, these findings indicate that CA2 neurons carry less spatial information than those in the other CA regions.…”

Section: Role In Behaviourmentioning

confidence: 90%

“…One study examined how social stimuli such as exposure to either novel or familiar animals would influence CA2 neuron firing in rats 30 . The authors of this study found that place fields shift significantly in response to social stimulation (that is, global remapping; see FIG.…”

Section: Role In Behaviourmentioning

confidence: 99%

“…However, it remains unclear how CA2 neurons integrate social processing with other aspects of episodic memory, such as time and space. Global remapping of CA2 neuron spatial firing may be one mechanism by which CA2 could encode social aspects of a memory 30 . Further, some evidence suggests that CA2 has a role in diseases associated with impaired social behaviour (BOX 2).…”

Section: Role In Behaviourmentioning

confidence: 99%

“…Not illustrated is that several properties of place fields in distal CA3 (closest to CA2; CA3a) closely resembled those in CA2 (REFS 87,88). Notably, place fields in CA2 changed with the passage of time (hours to days) and could shift significantly in response to social stimulation and novel objects (that is, global remapping) 30 . These results together suggest that CA2 is less sensitive to novel global contextual cues than to novel local cues and social stimuli.…”

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

Rediscovering area CA2: unique properties and functions

2016

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Hippocampal area CA2 has several features that distinguish it from CA1 and CA3, including a unique gene expression profile, failure to display long-term potentiation and relative resistance to cell death. A recent increase in interest in the CA2 region, combined with the development of new methods to define and manipulate its neurons, has led to some exciting new discoveries on the properties of CA2 neurons and their role in behaviour. Here, we review these findings and call attention to the idea that the definition of area CA2 ought to be revised in light of gene expression data.

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Identification of hippocampal area CA2 in hamster and vole brain

Siegler,

Shaughnessy,

Horman

et al. 2024

J of Comparative Neurology

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Prairie voles (Microtus ochrogaster) and Syrian, or golden, hamsters (Mesocricetus auratus) are closely related to mice (Mus musculus) and are commonly used in studies of social behavior including social interaction, social memory, and aggression. Hippocampal area CA2 is known to play a key role in these behaviors in mice and responds to social stimuli in rats, but CA2 has yet to be characterized in hamsters or voles, which are also used in studies of social behaviors. Here, we used immunofluorescence to determine whether CA2 could be molecularly identified in tissue from voles and hamsters. We found that staining for many CA2 markers was similar in these three species, with labeling seen in neurons at the distal end of the mossy fibers . In contrast, although perineuronal nets (PNNs) surround CA2 cells in mice, PNN staining differed across species. In voles, both CA2 and CA3 were labeled, whereas in hamsters, labeling was seen primarily in CA3. These results demonstrate that CA2 can be molecularly distinguished from neighboring CA1 and CA3 areas in voles and hamsters with several antibodies commonly used in mice. However, PNN staining is not useful for identifying CA2 in voles or hamsters, suggestive of differing roles for either PNNs or for the hippocampal subregions in social behavior. These findings reveal commonalities across species in the molecular profile of CA2 and should facilitate future studies of CA2 in these species.

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Social and novel contexts modify hippocampal CA2 representations of space

Cited by 163 publications

References 62 publications

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

Viewpoints: how the hippocampus contributes to memory, navigation and cognition

Rediscovering area CA2: unique properties and functions

Identification of hippocampal area CA2 in hamster and vole brain

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