Social and demographic characteristics, features of disease course and treatment options of inflammatory bowel disease in Russia: results of two multicenter studies

Belousova, Elena; Абдулганиева, Д. И.; Alexeeva, Olga; Alexeenko, S. A.; Baranovsky, A. Yu.; Valuyskikh, E. Yu.; Головенко, А. О.; Головенко, О. В.; Жигалова, Т. Н.; Knyazev, Oleg; Kulyapin, A. V.; Lakhin, A. V.; Ливзан, М. А.; Lubyanskaya, T. G.; Николаева, Н. Н.; Никитина, Н. В.; Nikulina, Inna; Осипенко, М. Ф.; Pavlenko, V. V.; Парфенов, А И; Rogachikov, Y. E.; Светлова, И. О.; Tkachev, Alexander; Ткаченко, Е. И.; Халиф, И. Л.; Chashkova, E. Yu.; Щукина, О. Б.; Yazenok, N. S.; Yakovlev, A. A.

doi:10.18786/2072-0505-2018-46-5-445-463

Cited by 45 publications

(14 citation statements)

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“…An epidemiological study in Russia, for example, found that its European part had 20.4 per 100,000 population for UC and 3.7 per 100,000 population for CD. 19 In one hand, the observed prevalence could partially be explained by the differences in healthcare access, database system, lifestyle and various risk factors as reported previously. 20,21 Another possible explanation might be that Central Asian, including Kazakhstan, has a traditional nomadic diet, which may lie somewhere between West and East Asian cuisines, resulting in intermediate prevalence rates.…”

Section: Impact Of Demographic and Clinical Characteristics On Ibd Awmentioning

confidence: 69%

“…In general, the situation concerning the IBD prevalence in Asian countries is very similar to a West-East gradient of 2:1 in IBD incidence in Europe [ 18 ], but with lower rates. An epidemiological study in Russia, for example, found that its European part had 20.4 per 100,000 population for UC and 3.7 per 100,000 population for CD [ 19 ]. In one hand, the observed prevalence could partially be explained by the differences in healthcare access, database system, lifestyle and various risk factors as reported previously [ 20 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and patient awareness of inflammatory bowel disease in Kazakhstan: a cross-sectional study

Kaibullayeva¹,

Ualiyeva²,

Oshibayeva³

et al. 2020

Intest Res

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Background/Aims: There has been a paucity of published data on the epidemiology of inflammatory bowel disease (IBD) in Central Asia and Kazakhstan. Therefore, we aimed to study IBD prevalence and patient awareness among adults in Kazakhstan. Methods: The cross-sectional study was carried out among subjects of both sexes aged 18 years and older using IBD Alert Questionnaire (CalproQuest), single fecal calprotectin test, and endoscopy with biopsy to verify IBD from January to December 2017, across regions of Kazakhstan. All participants were included in the study after providing informed consent.Results: Out of 115,556 subjects, there were 128 confirmed IBD cases, in which 36 Crohn’s disease (CD) and 92 ulcerative colitis (UC) cases identified. The age and sex-adjusted IBD prevalence were 113.9 (95% confidence interval [CI], 69.0–158.9) per 100,000 population. The age- and sex-adjusted prevalence for UC were 84.4 (95% CI, 44.8–123.9) and for CD were 29.5 (95% CI, 8.2–50.9) per 100,000 population.Conclusions: This is the first report on the prevalence of IBD with a verified diagnosis in the Central Asia and could be used to better plan and allocate healthcare resources for IBD management program.

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Section: Impact Of Demographic and Clinical Characteristics On Ibd Awmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Prevalence and patient awareness of inflammatory bowel disease in Kazakhstan: a cross-sectional study

Kaibullayeva¹,

Ualiyeva²,

Oshibayeva³

et al. 2020

Intest Res

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“…В России в течение последнего десятилетия были проведены 2 наиболее крупных эпидемиологических исследований касательно пациентов с ВЗК -исследование ESCApе (Epidemiological Study Of Occurrence, Clinical Course And Treatment Options Of Infl ammatory Bowel Disease In Russian Federation) и ESCApе-2 [14,15]. Исследование ESCApе было проведено в период 2011 года и охватывало данные о 1254 пациентах с язвенным колитом и 543 пациентах с болезнью Крона из 21 гастроэнтерологического центра 18-ти регионов РФ.…”

Section: обсуждение результатовunclassified

Features of inflammatory bowel diseases in St. Petersburg and peculiarities of basic therapy in the regional healthcare system: cross-sectional study results

Успенский

Иванов

Фоминых

et al. 2021

jour

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Background. Inflammatory bowel diseases (ulcerative colitis and Crohn’s disease) are serious problem in modern gastroenterology, as these diseases affect the working population, have a progressive chronic course, a high risk of disabling complications and require significant costs for the drug management.Aim. We wanted to assess the inflammatory bowel diseases structure and features of the use of basic drugs in outpatient and inpatient treatment in St. Petersburg, Russia.Materials and methods. A cross-sectional study was performed. Data about drug therapy, disease features and demographic from 42 outpatient institutions and from 6 city hospitals for the period 2018–2020 in St. Petersburg was collected. The analysis included data from 617 patients with ulcerative colitis and 455 patients with Crohn’s disease.Results. The median age of patients with ulcerative colitis was 44 years, which was statistically significant more than with Crohn’s disease (39 years). In ulcerative colitis, the left-sided localization of colon lesions (56%) prevailed over total colitis (23%) and proctitis (21%) In Crohn’s disease, the prevalence of ilecocolitis (36%) was approximately equal to the prevalence of colitis (35%), the frequency of terminal ileitis was significantly less (26%), other variants of gastrointestinal lesions were found in 3% cases. In Crohn’s disease compared to ulcerative colitis, the proportion of patients with mild disease was similar (36.6% and 38.2% respectively), but in in Crohn’s disease the frequency of severe disease there was more than three times compared to ulcerative colitis. There has been a significantly higher incidence of surgery in the past for Crohn’s disease compared to ulcerative colitis (14.8% and 2.6%, respectively). The vast majority of patients (more than 80%) received therapy with oral 5-aminosalycilic acid drugs. Topical formulas of 5-aminosalycilic acid drugs in ulcerative colitis were prescribed in about 50% of cases (it was significantly less than commonly used in Crohn’s disease). Corticosteroids were used in the treatment of 16.6% of ulcerative colitis patients and in 24.4% Crohn’s disease patients. In both diseases in the conditions of inpatient treatment, this group of drugs was used several times more often than in outpatient observation. Immunosuppressants (tyopurines, methotrexate) were administered in 6.9% ulcerative colitis patients with and in 17.0% Crohn’s disease patients.Conclusion. Clinical features of inflammatory bowel diseases in St. Petersburg and the features of basic therapy in comparison with the nationwide indicators in Russia demonstrate similar trends. The key problem points of therapy of inflammatory bowel diseases remains the widespread use of drugs of the group of 5-aminosalycilic acid in Crohn’s disease, insufficient use of rectal forms of 5-aminosalycilic acid in ulcerative colitis, a relatively small frequency of use of immunosupressors to maintain remission in Crohn’s disease. The solution to the problem of optimizing the therapy of patients with inflammatory bowel diseases within the framework of routine practice includes educational activities, as well as the creation of a regional register of patients with inflammatory bowel diseases in St. Petersburg.

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“…У больных Пс нередко развиваются периферический артрит, поражение осевого скелета, энтезит, теносиновит, дактилит, при этом в 20% случаев суставные проявления предшествуют поражению кожи [20]. Многообразие клинических проявлений болезни Крона (БК) определяется поражением любого отдела желудочно-кишечного тракта (ЖКТ) и частым развитием осложнений (свищей и стриктур), что затрудняет диагностику на ранних стадиях, до развития осложнений, и может существенно повлиять на результаты лечения, а также отдаленные исходы заболевания [21][22][23].…”

Section: процесс формирования согласительных рекомендацийunclassified

“…В то же время у ряда больных диагностика затягивается на десятилетия (до 420 мес при ЯК и 480 мес при БК). Обращает на себя внимание то, что в среднем диагноз БК устанавливался гораздо позже диагноза ЯК [22]. По данным О.Б.…”

Section: процесс формирования согласительных рекомендацийunclassified

Early administration of genetically engineered biological agents for immune-mediated inflammatory diseases: opportunities and prospects. An experts’ opinion

et al. 2020

Self Cite

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Psoriasis (Ps), psoriatic arthritis (PsA), and inflammatory bowel diseases (IBDs) are characterized by a progressive course and commonly result in disability. Therefore, their early diagnosis with the assessment of a clinical phenotype and unfavorable prognostic factors and the timely initiation of therapy are important. The paper provides the expert consensus on the definition of the early stage of Ps, PsA, and IBDs, their treatment goals and main unfavorable prognostic factors. It also gives the rationale for the early use of biological agents in patients with immune-mediated inflammatory diseases.

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Social and demographic characteristics, features of disease course and treatment options of inflammatory bowel disease in Russia: results of two multicenter studies

Cited by 45 publications

References 45 publications

Prevalence and patient awareness of inflammatory bowel disease in Kazakhstan: a cross-sectional study

Prevalence and patient awareness of inflammatory bowel disease in Kazakhstan: a cross-sectional study

Features of inflammatory bowel diseases in St. Petersburg and peculiarities of basic therapy in the regional healthcare system: cross-sectional study results

Early administration of genetically engineered biological agents for immune-mediated inflammatory diseases: opportunities and prospects. An experts’ opinion

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