Social and clinical determinants of quality of life in Parkinson's disease in a Russian cohort study

Winter, Yaroslav; Campenhausen, Sonja von; Popov, Georgy; Reese, Jens Peter; Balzer‐Geldsetzer, Monika; Кукшина, А. А.; Zhukova, T. V.; Bertschi, Natalia; Bötzel, Kai; Gusev, Eugene; Oertel, Wolfgang H.; Dodel, Richard; Guekht, Alla

doi:10.1016/j.parkreldis.2009.11.012

Cited by 43 publications

(46 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In comparison, the HRQoL related to mental health is more severely impaired in neurodegenerative diseases (e.g. Parkinson's disease, Huntington's disease) [3,17,40,44,45]. In our study, the HRQoL as measured by the SF-36 was most affected in ALS and least affected in MG. Padua et al [31] investigated the HRQoL in MG and found much lower scores in the domains of the SF-36.…”

Section: Discussionmentioning

confidence: 43%

See 1 more Smart Citation

Health-related quality of life in ALS, myasthenia gravis and facioscapulohumeral muscular dystrophy

et al. 2010

Self Cite

View full text Add to dashboard Cite

Neuromuscular disorders are rare diseases with a chronic and debilitating course. Unfortunately, data on the health-related quality of life (HRQoL) in neuromuscular diseases are limited. The objective of this multicentre cross-sectional study was to compare the HRQoL in patients with amyotrophic lateral sclerosis (ALS), facioscapulohumeral muscular dystrophy (FSHD) and myasthenia gravis (MG) and to identify the determinants of the HRQoL in these diseases. We recruited 91 consecutive outpatients with ALS (n = 37), FSHD (n = 17) or MG (n = 37) in seven specialized German health centres. The HRQoL was determined using the 36-Item Short Form Health Survey (SF-36) and the EuroQol (EQ-5D). Independent predictors of the HRQoL were identified using multiple regression analysis. The HRQoL in all domains of the SF-36, except for bodily pain, was significantly reduced. The domains related to physical health (physical functioning, physical role) were most affected. The EQ-5D-index score was most reduced in ALS (0.54) and least reduced in MG (0.89). Independent predictors of a reduced HRQoL were disease severity and depression in ALS, and disease severity, depression, older age and increased body-mass index in MG. The patterns of HRQoL-impairment in neuromuscular disorders share some common features, such as a more pronounced reduction in the HRQoL related to physical health, but there are a number of disease-specific features that should be considered in outcomes of clinical trials and treatment guidelines. In addition to the treatment of motor symptoms, greater attention should be paid to the treatment of depression, which was found to be among the independent predictors of the HRQoL in ALS and MG.

show abstract

Section: Discussionmentioning

confidence: 43%

“…Depression was also found to be an important determinant of the HRQoL in other chronic neurological diseases, such as Parkinson's disease and Huntington's disease [3,17,40,44,45]. Interestingly, age was among the independent HRQoL-predictors in MG but not in ALS.…”

Section: Discussionmentioning

confidence: 97%

Health-related quality of life in ALS, myasthenia gravis and facioscapulohumeral muscular dystrophy

et al. 2010

Self Cite

View full text Add to dashboard Cite

show abstract

“…Representing the impact of a disease on a person's self-perceived well-being, HrQoL is an important aspect in the healthcare of chronic diseases such as neurodegenerative disorders. The majority of studies evaluating HrQoL in parkinsonian disorders concentrated on idiopathic PD [6][7][8][9][10][11][12] and only a few investigated APS [15,16,18,22] .…”

Section: Discussionmentioning

confidence: 99%

“…In the last decade, a large number of studies evaluated HrQoL in PD in different countries [6][7][8][9][10][11][12][13][14] . In contrast, only a few studies evaluated HrQoL in MSA and PSP ( table 1 ).…”

Section: Health-related Quality Of Life Inmentioning

confidence: 99%

Health-Related Quality of Life in Multiple System Atrophy and Progressive Supranuclear Palsy

Winter¹,

Spottke²,

Stamelou³

et al. 2011

Neurodegener Dis

Self Cite

View full text Add to dashboard Cite

Objective: Multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), known as atypical parkinsonian syndromes (APS), are neurodegenerative disorders with severe disability and decreased life expectancy. Little is known about the health-related quality of life (HrQoL) and its determinants in patients with those disorders. The objective of our cross-sectional study was to evaluate the HrQoL in patients with APS and to identify the determinants of HrQoL. Methods: A total of 101 consecutive patients with MSA (n = 54) and PSP (n = 47) were recruited in four German neurological centers. Disease severity was assessed using the Hoehn and Yahr stages and the Unified MSA Rating Scale. The HrQoL was evaluated using the EuroQol instrument (EQ-5D and EQ-VAS). Independent determinants of HrQoL were identified in multiple regression analyses. Results: The mean EQ-VAS score was 52% lower than that reported for the general population (36.9 ± 18.3 vs. 77.4 ± 19.0). Of the study participants, 63% reported severe problems in at least one dimension of the EQ-5D. Cerebellar dysfunction was associated with a more considerable reduction of HrQoL. Independent determinants of reduced HrQoL were female gender, <12 years of education, disease severity, a decreased number of persons in the household and depression. Conclusions: The HrQoL in MSA and PSP is considerably reduced. While therapeutic options in the treatment of motor symptoms remain restricted, greater attention should be paid to the treatment of depression, which was identified among independent determinants of HrQoL. Independent determinants of HrQoL should be considered when developing healthcare programs aimed at improving the HrQoL in APS.

show abstract

“…According to studies dealing with physical activity and PD, dance therapy can also be helpful since it encourages social interaction and psychosocial support, while demanding dynamic balance practice and adjusting to environment. One of the studies [64] that patients who do not live in a community tend to have worse quality of life than those who do [66]. Since the patients find relationships with close people extremely important, an adequate social support is essential for maintaining the well-being.…”

Section: The Effects Of Exercise On the Social Aspects Of Quality Of mentioning

confidence: 99%

The Effects of Exercise on People with Parkinson’s Disease—Review

Iva¹

2017

APD

View full text Add to dashboard Cite

Quality of life encompasses physical, psychological and social aspects of health. Apart from motor symptoms (physical aspects), Parkinson's disease (PD) is also closely related with various non-motor symptoms (psychological and social aspects) that can undermine quality of life greatly, even in early stages of the disease. Most research studies in this field focus on analysis of motor symptoms in PD sufferers. Although benefits of physical activity for the psychosocial quality of life are well-known, they have been mostly neglected in case of the people suffering from PD. Numerous studies clearly show that training programs can ameliorate the quality of life as far as non-motor functions in PD sufferers are concerned. The only psychological aspects of the disease related to the effects of exercise that have been researched so far are depression and cognitive functions. Depression is the most common denominator of poor quality of life, while dementia often accompanies the Parkinson's disease. Studies have shown positive effects of exercise on the social life of those suffering from the disease, especially in case of group exercise. Studying psychological and social aspects of such chronic conditions as PD is of utmost importance for monitoring the patient's adjustment to the disease, functioning with it, as well as the overall well-being and satisfaction with life. Thus far, the results have been pointing towards improvement of the quality of life. Exercise is a readily available method of treatment in case of PD, especially if applied in the early stages of the disease. In addition to reviewing the existing studies on the relation between exercise and quality of life of the patients, this paper will also focus on the way the psychological and social aspects of PD are influenced by exercise.

show abstract

Social and clinical determinants of quality of life in Parkinson's disease in a Russian cohort study

Cited by 43 publications

References 30 publications

Health-related quality of life in ALS, myasthenia gravis and facioscapulohumeral muscular dystrophy

Health-related quality of life in ALS, myasthenia gravis and facioscapulohumeral muscular dystrophy

Health-Related Quality of Life in Multiple System Atrophy and Progressive Supranuclear Palsy

The Effects of Exercise on People with Parkinson’s Disease—Review

Contact Info

Product

Resources

About