Social and attention factors during infancy and the later emergence of autism characteristics

Elsabbagh, Mayada; Holmboe, Karla; Gliga, Teodora; Mercure, Evelyne; Hudry, Kristelle; Charman, Tony; Baron‐Cohen, Simon; Bolton, Patrick; Johnson, Mark H.

doi:10.1016/b978-0-444-53884-0.00025-7

Cited by 43 publications

(34 citation statements)

References 48 publications

(62 reference statements)

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“…Similar behavioral symptoms have been observed in children with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), which suggests the possibility of common underlying neurobiological substrates (3, 4). Common genetic elements have been identified as well.…”

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confidence: 60%

Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence forCHRNA7Moderation

Ross

Hunter

Hoffman

et al. 2016

AJP

104

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Objective α7-Nicotinic receptors are involved in the final maturation of GABA inhibitory synapses before birth. Choline at levels found in the amniotic fluid is an agonist at α7-nicotinic receptors. The authors conducted a double-blind placebo-controlled trial to assess whether high-dose oral phosphatidylcholine supplementation during pregnancy to increase maternal amniotic fluid choline levels would enhance fetal development of cerebral inhibition and, as a result, decrease childhood behavior problems associated with later mental illness. Method The authors previously reported that newborns in the phosphatidylcholine treatment group have increased suppression of the cerebral evoked response to repeated auditory stimuli. In this follow-up, they report parental assessments of the children’s behavior at 40 months of age, using the Child Behavior Checklist. Results At 40 months, parent ratings of children in the phosphatidylcholine group (N=23) indicated fewer attention problems and less social withdrawal compared with the placebo group (N=26). The improvement is comparable in magnitude to similar deficits at this age associated with later schizophrenia. The children’s behavior is moderated by CHRNA7 variants associated with later mental illness and is related to their enhanced cerebral inhibition as newborns. Conclusions CHRNA7, the α7-nicotinic acetylcholine receptor gene, has been associated with schizophrenia, autism, and attention deficit hyperactivity disorder. Maternal phosphatidylcholine treatment may, by increasing activation of the α7-nicotinic acetylcholine receptor, alter the development of behavior problems in early childhood that can presage later mental illness.

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mentioning

confidence: 60%

Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence forCHRNA7Moderation

Ross

Hunter

Hoffman

et al. 2016

AJP

104

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“…MRI studies have revealed that the presentation of faces leads to diminished (Schultz et al 2000) or atypical (Samson et al 2011) activations of the fusiform gyri in individuals with ASD. It has been suggested that, in ASD, a lack of expertise resulting from diminished early attention orientation towards faces (Elsabbagh et al 2011) might manifest as a degraded sensitivity to perceptual cues (Dawson et al 2005) underlying social processing of faces in the typical development. However, the degree to which the sensitivity to perceptual cues impacts social judgment remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Atypical Social Judgment and Sensitivity to Perceptual Cues in Autism Spectrum Disorders

d’Arc

Ramus

Lefebvre

et al. 2014

J Autism Dev Disord

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Evaluation of faces is an important dimension of social relationships. A degraded sensitivity to facial perceptual cues might contribute to atypical social interactions in autism spectrum disorder (ASD). The current study investigated whether face based social judgment is atypical in ASD and if so, whether it could be related to a degraded sensitivity to facial perceptual cues. Individuals with ASD (n = 33) and IQ-and age-matched controls (n = 38) were enrolled in this study. Watching a series of photographic or synthetic faces, they had to judge them for ''kindness''. In synthetic stimuli, the amount of perceptual cues available could be either large or small. We observed that social judgment was atypical in the ASD group on photographic stimuli, but, contrarily to the prediction based on the degraded sensitivity hypothesis, analyses on synthetic stimuli found a similar performance and a similar effect of the amount of perceptual cues in both groups.Further studies on perceptual differences between photographs and synthetic pictures of faces might help understand atypical social judgment in ASD.

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“…Unlike children with ADHD who are primarily referred to interventions for their behavioural problems (Pelham, Fabiano, & Massetti, 2005) (Bailey, Raspa, Olmsted, & Holiday, 2008) and Autism (Elsabbagh, et al, 2011). In many cases children with ID share similar behavioural attention profiles, characterized by poor inhibition, problems concentrating and impulsivity.…”

Section: Potentials Of Cognitive Training For Children With Intellectmentioning

confidence: 99%

Cognitive training as a resolution for early executive function difficulties in children with intellectual disabilities

Kirk

Gray

Riby

et al. 2015

Research in Developmental Disabilities

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NOTICE: this is the author's version of a work that was accepted for publication in Research in Developmental Disabilities. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reected in this document. Changes may have been made to this work since it was submitted for publication. A denitive version was subsequently published in Research in Developmental Disabilities, 38, March 2015, 10.1016/j.ridd.2014 Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. Core executive functions (EF) such as attention, and working memory have been strongly associated with academic achievement, language development and behavioural stability. In the case of children who are vulnerable to cognitive and learning problems because of an underlying intellectual disability, EF difficulties will likely exacerbate an already compromised cognitive system. The current review examines cognitive training programs that aim to improve EF, specifically focusing on the potential of this type of intervention for children who have intellectual disabilities. We conclude that despite considerable discrepancies regarding reported intervention effects, these inconsistencies can be attributed to flaws in both program and study design.We discuss the steps needed to address these limitations and to facilitate the advancement of nonpharmaceutical interventions for children with intellectual disabilities.

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Social and attention factors during infancy and the later emergence of autism characteristics

Cited by 43 publications

References 48 publications

Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence forCHRNA7Moderation

Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence forCHRNA7Moderation

Atypical Social Judgment and Sensitivity to Perceptual Cues in Autism Spectrum Disorders

Cognitive training as a resolution for early executive function difficulties in children with intellectual disabilities

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