Social affective outcomes and brain injury in children and adolescents treated for brain tumours

Igoshina, Elizaveta; Wu, Liliana C; Moxon‐Emre, Iska; Mabbott, Donald

doi:10.1016/s2352-4642(23)00079-2

Cited by 5 publications

(8 citation statements)

References 92 publications

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“…These findings are significant given the risks posed by poor social adjustment and isolation to the wellbeing of SPBT, including increased psychological distress, 37 suicidal ideation, risky health behaviors, and new‐onset chronic conditions 7 . Moreover, social information processing—and more specifically, underlying social affective functions—influences social behavior and social adjustment 14,15 . Previous research with SPBT has focused on social attention and face processing as predictors of social impairments, 17,20–22 less and worse peer interactions, 18 and fewer friendships 23 .…”

Section: Discussionmentioning

confidence: 99%

“…7 Moreover, social information processing-and more specifically, underlying social affective functions-influences social behavior and social adjustment. 14,15 Previous research with SPBT has focused on social attention and face processing as predictors of social impairments, 17,[20][21][22] less and worse peer interactions, 18 and fewer friendships. 23 Taken together, these findings provide a more nuanced picture of the interplay between components of key social affective functions (i.e., social attention and FER) and social impairment in SPBT.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers have posited three core components of social competence in children with brain disorders: 1) social information processing, comprised of cognitive‐executive functions, social problem solving, and social affective functions 2) social interaction and 3) social adjustment 14 . Specific research on the social affective functions of SPBT was addressed in a recent review, which highlighted the interplay between emotion regulation, emotion recognition, and structural changes to the brain following PBT treatment 15 . However, the role of social attention in this dynamic was not addressed in this review.…”

Section: Introductionmentioning

confidence: 99%

“…However, the role of social attention in this dynamic was not addressed in this review. Social attention, or the focus of one's visual gaze in social situations, is one component of social affective functions 16 —and social information processes more broadly—but few have examined it as a risk factor for poor social outcomes among SPBT. In contrast, emotion recognition has been identified as an area in need of future research and a potential intervention target to improve social outcomes in SPBT 17 .…”

Section: Introductionmentioning

confidence: 99%

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Social impairment in survivors of pediatric brain tumors via reduced social attention and emotion‐specific facial expression recognition

Fantozzi,

Anil,

McHugh

et al. 2024

Pediatric Blood & Cancer

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Background/objectivesSurvivors of pediatric brain tumors (SPBT) experience significant social challenges, including fewer friends and greater isolation than peers. Difficulties in face processing and visual social attention have been implicated in these outcomes. This study evaluated facial expression recognition (FER), social attention, and their associations with social impairments in SPBT.MethodsSPBT (N = 54; ages 7–16) at least 2 years post treatment completed a measure of FER, while parents completed measures of social impairment. A subset (N = 30) completed a social attention assessment that recorded eye gaze patterns while watching videos depicting pairs of children engaged in joint play. Social Prioritization scores were calculated, with higher scores indicating more face looking. Correlations and regression analyses evaluated associations between variables, while a path analysis modeling tool (PROCESS) evaluated the indirect effects of Social Prioritization on social impairments through emotion‐specific FER.ResultsPoorer recognition of angry and sad facial expressions was significantly correlated with greater social impairment. Social Prioritization was positively correlated with angry FER but no other emotions. Social Prioritization had significant indirect effects on social impairments through angry FER.ConclusionFindings suggest interventions aimed at improving recognition of specific emotions may mitigate social impairments in SPBT. Further, reduced social attention (i.e., diminished face looking) could be a factor in reduced face processing ability, which may result in social impairments. Longitudinal research is needed to elucidate temporal associations between social attention, face processing, and social impairments.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Social impairment in survivors of pediatric brain tumors via reduced social attention and emotion‐specific facial expression recognition

Fantozzi,

Anil,

McHugh

et al. 2024

Pediatric Blood & Cancer

View full text Add to dashboard Cite

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“…15 These are skills that many PBTS struggle with. 18,19 To gain insight into the frequency and quality of social interactions of children, a daily diary can be used to gather data that may elude other research methods. 20 Structured diary methods usually consist of a list of social interactions that a child records having taken part in, and are typically completed daily over 1-2 weeks.…”

mentioning

confidence: 99%

Social participation of school‐aged survivors of pediatric brain tumors: A daily diary report

Tamboli,

Means,

Jurbergs

et al. 2023

Pediatric Blood & Cancer

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BackgroundDifficulties with social functioning are common among survivors of pediatric brain tumors. Social participation is an understudied measure of social functioning that is associated with emotional health across the lifespan. This paper uses a diary method to assess the social participation of survivors of pediatric brain tumors in middle childhood.ProcedureSurvivors of pediatric brain tumors (N = 47; age 10.6 ± 1.4 years; 51.1% male, 89.4% White) who were 5.3 (SD = 2.4, range: 2–9.9) years post therapy completed a daily diary assessment of social interaction (5–7 days) and an objective measure of facial affect recognition. The participant's caregiver completed the NIH Toolbox Emotion Measures and a background information questionnaire.ResultsOverall, frequency and quality of reported social interactions were low for survivors, with a large subset of survivors (n = 16, 34%) endorsing fewer than 10 social interactions over the course of a typical school week, and almost half of parents (48.9%) reporting that their child participates in zero social activities outside of school during a typical week. Participants engaged in more positive social participation exhibited stronger social skills (facial affect recognition (F(2,44) = 4.85, p < .05).ConclusionsSchool‐aged survivors of pediatric brain tumors seemed to be infrequently engaged in social participation and quality interaction with peers. More specifically, the interactions most commonly reported on the diary assessment are not indicative of friendship development and maintenance. Survivors of pediatric brain tumors would likely benefit from interventions designed to increase quality time spent with peers.

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White matter connectivity and social functioning in survivors of pediatric brain tumor

Hocking,

Schultz,

Yerys

et al. 2024

J Neurooncol

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Objective Survivors of pediatric brain tumors (SPBT) are at risk for social deficits, fewer friendships, and poor peer relations. SPBT also experience reduced brain connectivity via microstructural disruptions to white matter from neurological insults. Research with other populations implicates white matter connectivity as a key contributor to poor social functioning. This case-controlled diffusion-weighted imaging study evaluated structural connectivity in SPBT and typically developing controls (TDC) and associations between metrics of connectivity and social functioning. Methods Diffusion weighted-imaging results from 19 SPBT and 19 TDC were analyzed using probabilistic white matter tractography. Survivors were at least 5 years post-diagnosis and 2 years off treatment. Graph theory statistics measured group differences across several connectivity metrics, including average strength, global efficiency, assortativity, clustering coefficient, modularity, and betweenness centrality. Analyses also evaluated the effects of neurological risk on connectivity among SPBT. Correlational analyses evaluated associations between connectivity and indices of social behavior. Results SPBT demonstrated reduced global connectivity compared to TDC. Several medical factors (e.g., chemotherapy, recurrence, multimodal therapy) were related to decreased connectivity across metrics of integration (e.g., average strength, global efficiency) in SPBT. Connectivity metrics were related to peer relationship quality and social challenges in the SPBT group and to social challenges in the total sample. Conclusions Microstructural white matter connectivity is diminished in SPBT and related to neurological risk and peer relationship quality. Additional neuroimaging research is needed to evaluate associations between brain connectivity metrics and social functioning in SPBT.

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Social affective outcomes and brain injury in children and adolescents treated for brain tumours

Cited by 5 publications

References 92 publications

Social impairment in survivors of pediatric brain tumors via reduced social attention and emotion‐specific facial expression recognition

Social impairment in survivors of pediatric brain tumors via reduced social attention and emotion‐specific facial expression recognition

Social participation of school‐aged survivors of pediatric brain tumors: A daily diary report

White matter connectivity and social functioning in survivors of pediatric brain tumor

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