“…Specifically, there are strong lines of evidence that the induction of bidirectional synaptic plasticity in the hippocampus is mediated by different calcium sources, with certain protocols requiring synergistic activation of multiple calcium 16, 2017; sources (Brager and Johnston, 2007;Christie et al, 1996;Golding et al, 2002;Huber et al, 1995;Nishiyama et al, 2000;Raymond, 2007). These studies show that plasticity induction is dependent on influx of calcium through NMDA receptors (Christie et al, 1996;Collingridge and Bliss, 1987;Collingridge et al, 1983;Morris et al, 1986;Mulkey and Malenka, 1992;Nishiyama et al, 2000;Tsien et al, 1996;Wang et al, 2003), voltage-gated calcium channels (Brager and Johnston, 2007;Christie et al, 1996;Christie et al, 1997;Johnston et al, 1992;Moosmang et al, 2005;Nicholson and Kullmann, 2017;Wang et al, 2003), store-operated calcium channels (Baba et al, 2003;Garcia-Alvarez et al, 2015;Majewski and Kuznicki, 2015;Majewski et al, 2016;Prakriya and Lewis, 2015) and receptors on the ER activated by metabotropic receptors on the plasma membrane (Huber et al, 2000;Nishiyama et al, 2000;Verkhratsky, 2002). Additionally, voltage-gated channels and their auxiliary subunits (Anirudhan and Narayanan, 2015;Brager et al, 2013;Chen et al, 2006;Chung et al, 2009a;Chung et al, 2009b;Johnston et al,...…”