So Different but Equal: 33 Longevity Genes' Loci in the Roma and in the General Population of Croatia

Škarić‐Jurić, Tatjana; Celinšćak, Željka; Šetinc, Maja; Bočkor, Luka; Marković, Anita Stojanović; Petranović, Matea Zajc; Salihović, Marijana Peričić; Deelen, Joris; Janičijević, Branka; Narančić, Nina Smolej

doi:10.26720/anthro.22.04.29.1

Cited by 1 publication

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“…It should be emphasised that in previous research, GG was assigned as a longevity genotype in rs16847897 [ 31 , 32 ] and in rs4977756 [ 33 ], which makes this result of the subjective health and functional ability assessment consistent with the expected longevity of these individuals. However, for rs533984 in the MRE11A gene, better scores were associated with the AA genotype, which was not previously related to longevity [ 34 , 35 ].…”

Section: Resultsmentioning

confidence: 86%

“…Additionally, interactions between this SNP in the DNA-repair pathway and SNPs from the insulin/insulin-like growth factor signalling pathway (IIS) were significantly associated with longevity, as demonstrated by the two- and three-loci interaction analysis [ 34 ]. In our Croatian sample [ 35 ], out of 43 longevity genes’ loci, rs533984 was the only one that differentiated old (85+) and young (20–35 yrs) cohorts, with the G allele being more frequent in the former group. Despite those two findings pointing to the G allele as associated with longevity phenotype, the results presented here relate minor A allele with better functional ability status in the oldest-old cohort.…”

Section: Discussionmentioning

confidence: 99%

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Genes Involved in DNA Damage Cell Pathways and Health of the Oldest-Old (85+)

Šetinc,

Zajc Petranović,

Slivšek

et al. 2023

Genes

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Some sources report a connection of cellular senescence with chronic pathological conditions; however, the association between particular cellular processes and general health is rarely examined. This study aims to test the relationship of general health with DNA damage pathways that play a crucial role in senescence. The association of ten selected SNPs with subjective and objective general health and functional ability indicators has been tested in 314 oldest-old people from Croatia. Multivariate logistic regression was employed to simultaneously test the impact of variables potentially influencing targeted health and functional ability variables. The best model, explaining 37.1% of the variance, has six independent significant predictors of functional ability scores: rs16847897 in TERC, rs533984 in MRE11A, and rs4977756 in CDKN2B, chronic disease count, Mini-Mental State Examination scores, and age at surveying. In conclusion, the examined ten loci involved in DNA damage repair pathways showed a more significant association with self-rated health and functional ability than with the number of disease or prescribed medicaments. The more frequent, longevity-related homozygote (GG) in rs16847897 was associated with all three aspects of self-assessments—health, mobility, and independence—indicating that this TERC locus might have a true impact on the overall vitality of the oldest-old persons.

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