So-Called "Brain Purpura" or "Hemorrhagic Encephalitis"

Spontaneous diseases observed in 600 monkeys

“…At first sight the resemblance of the lesions to those of "brain purpura" or "hsmorrhagic encephalitis " suggested itself (see Alpers, 1928) and no tubercle bacilli were demonstrated in the foci which did not show the structure typical of a tubercle. The other organs were, however, extensively tuberculous, and inoculation of brain-substance into two guinea-pigs gave rise within five weeks to widespread tuberculous lesions.…”

Arsenical Encephalopathy

“…Obermiller (1913) and Stiuhmer (1919) state that there may be no pathological changes in arsenical encephalopathy other than cerebral congestion and oedema. The characteristic lesion, however, in this condition is multiple plugged capillaries with petechial haemorrhages and surrounding necrosis and demyelination (Russell, 1937;Strauss and Globus, 1930;Alpers, 1928).…”