SNX10 regulates the clearance of mitochondrial proteins and mitochondrial bioenergetics
Laura Trachsel-Moncho,
Benan John Mathai,
Chiara Veroni
et al.
Abstract:We here show that SNX10 localizes to endocytic compartments in a PtdIns3P-dependent manner and that mutations in the PX domain associated with autosomal recessive osteopetrosis prevent its endosomal recruitment. We demonstrate that SNX10 regulates endosomal trafficking but also interacts with mitochondrial proteins and shows dynamic interactions with mitochondria. Intriguingly, SNX10 and RAB5A-positive vesicles contain mitochondrial material and stain positive for LC3B. SNX10-positive vesicles contain COX-IV a… Show more
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