SNP Ser38Gly in the β-subunit of potassium channel gene KCNE1 and thyrotoxic cardiomyopathy in patients with Graves’ disease

Successful treatment of severe thyrotoxicosis with radioiodine therapy in a patient with thyrotoxic cardiomyopathy

“…TCM is defined by myocardial damage caused by the toxic effects of excessive thyroid hormones resulting in alterations in energy production by myocytes, intracellular metabolism and myofibril contractile function 1 . Main manifestations of TCMP are left ventricular hypertrophy, heart rhythm disturbances (commonly AF), dilation of heart chambers with heart failure (HF), pulmonary hypertension, and diastolic dysfunction.…”

“…Duration of hyperthyroidism, male sex and advanced age are the main predictors of development of TCM (1). Most studies agree that once the effect of thyroid hormones is eliminated, myocardial damage may be reversible in patients with less than 6 months disease duration (3)(4)(5).…”