SNP rs12794714 of CYP2R1 is associated with serum vitamin D levels and recurrent spontaneous abortion (RSA): a case–control study

Liu, Ding-Yuan; Li, Ren-Yan; Fu, Lijuan; Adu‐Gyamfi, Enoch Appiah; Yang, Yin; Xu, Ying; Zhao, Lijing; Zhang, Tianfeng; Bao, Huaqiong; Xiaoou, Xu; Gao, Xiaohan; Xueniu, Yang; Ding, Yubin

doi:10.1007/s00404-021-06004-y

Cited by 3 publications

(14 citation statements)

References 46 publications

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“…The subgroup analysis was performed by whether the average age of the population was ‘ > 35’. There were 11 studies 11–16,19,20,22–24 included with serum vitamin D levels as a continuous variable. The results showed serum vitamin D levels were lower in RSA patients than controls at age 35 younger ( SMD = ‐2.46, 95% CI : ‐3.33, ‐1.56, P < .001).…”

Section: Resultsmentioning

confidence: 99%

“…Subgroup analyses were performed by different regional origins of the populations, and 14 studies[11][12][13][14][15][16][17][18][19][20][21][22][23][24] were included with serum vitamin D levels as a continuous variable. The subgroup analyses were all performed using a random effects model because of the significant heterogeneity.…”

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confidence: 99%

“…The results showed RSA patients in Asia had lower serum vitamin D levels than controls (SMD = -1.94, 95%CI: -2.69, -1.19, P < .001), but European RSA patients and controls did not show significant difference (SMD = -0.19, 95%CI: -.50, 0.12, P = .225). Twelve studies[11][12][13][14][15][16]18,19,[21][22][23][24] were included with serum vitamin D levels as a dichotomous variable. The results showed pregnant women with VDD in Asia were at higher risk of developing RSA (OR = 6.27, 95%CI: 2.61, 15.04, P < .001), but there was no significant association between VDD and RSA in pregnant women in Europe (OR = 2.02, 95%CI: .99, 4.08, P = .050).…”

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confidence: 99%

“…The results showed pregnant women with VDD in Asia were at higher risk of developing RSA (OR = 6.27, 95%CI: 2.61, 15.04, P < .001), but there was no significant association between VDD and RSA in pregnant women in Europe (OR = 2.02, 95%CI: .99, 4.08, P = .050). The results are illustrated in Figure3.The subgroup analysis was carried out according to the assay method of serum vitamin D, and 14 studies[11][12][13][14][15][16][17][18][19][20][21][22][23][24] were included with serum vitamin D levels as a continuous variable. The subgroup analysis results showed there was no significant difference between the RSA group and the control group when serum vitamin D levels were measured by LC-MS/MS (SMD = -.33, 95%CI: -1.57, .91, P = .601) and other methods (SMD = .01, 95%CI: -.21, 0.24, P = .903).…”

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confidence: 99%

“…The results were shown in Figure4.The subgroup analysis was performed by whether the average age of the population was ' > 35' . There were 11 studies[11][12][13][14][15][16]19,20,[22][23][24] TA B L E 1 †Testing methods: LC-MS/MS: Liquid chromatograph-mass spectrometer. CM: Chemiluminescence method.…”

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Association between serum vitamin D level during pregnancy and recurrent spontaneous abortion: A systematic review and meta‐analysis

Chen

Wang

Zhang

et al. 2022

American J Rep Immunol

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Problem Previous studies had shown that there might be an association between serum vitamin D concentrations and the occurrence of recurrent spontaneous abortion (RSA). However, the conclusions remained controversial. The objective of this study was to systematically review the evidence for an epidemiological association between vitamin D and RSA. Method of study The literature search was performed in the following databases: PubMed, Web of Science, Embase and Chinese databases. The I2 statistic was used to evaluate heterogeneity. Effect sizes were calculated using fixed or random effects models, including standardized mean difference (SMD), odds ratios (OR) and their 95% confidence intervals (95% CI). Then, we performed subgroup analysis, sensitivity analysis and publication bias analysis. Results Fourteen studies from five countries were included. Based on the results, patients with RSA had lower vitamin D levels than controls (SMD = ‐1.48, 95% CI: ‐2.01, ‐.94, P < .001), and pregnant women with vitamin D deficiency (VDD) had a higher risk of developing RSA (OR = 4.02, 95% CI: 2.23, 7.25, P < .001). There was remarkable heterogeneity between studies (I2SMD = 97.3%, P < .001; I2OR = 82.2%, P < .001). The results of the subgroup analysis suggested that heterogeneity may be caused by the assay method, age and region. Sensitivity analysis showed the analysis results were robust. Conclusion Patients with RSA had lower serum vitamin D levels than normal pregnant women, and pregnant women with VDD might be at higher risk for RSA.

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Association between serum vitamin D level during pregnancy and recurrent spontaneous abortion: A systematic review and meta‐analysis

Chen

Wang

Zhang

et al. 2022

American J Rep Immunol

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The effect of MicroRNAs variants on idiopathic recurrent pregnancy loss

Chen

Yin

Yao

2023

J Assist Reprod Genet

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Role of polymorphic loci VDR rs10735810, MTHFR rs1801131, MTHFR rs1801133, MTR rs1805087, MTRR rs1801394 AND VEGFA rs3025039 in missed abortion: A prospective cohort study

Ramazanova¹,

Radzinsky²,

Хамошина³

et al. 2022

Kuban. nauсh. med. vestnik

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Background. Premature termination of pregnancy, including miscarriage, remains among the critical problems in modern obstetrics and gynaecology practices. In the context of early gestational failure and the notion that 80% of early miscarriages are triggered by genetic reset — some natural filter — an analysis of current knowledge of the genetic aspects of missed abortion (MA) appears relevant.Objectives. A study of the haplotype frequencies for VDR rs10735810, MTHFR rs1801131, MTHFR rs1801133, MTR rs1805087, MTRR rs1801394 and VEGFA rs3025039 polymorphic loci and their association with vitamin D deficiency in women with missed abortion.Methods. A total of 178 women aged 18 to 41 years were examined. The main cohort consisted of MA patients (n = 101) who were divided between cohort I (n = 58; patients with primary MA) and cohort II (n = 43; patients with recurrent MA). The control cohort (n = 77) consisted of women with a successful pregnancy (Z34.0) entailing a term and live birth. Genotyping of polymorphic loci VDR rs10735810, MTHFR rs1801131, MTHFR rs1801133, MTR rs1805087, MTRR rs1801394 and VEGFA rs3025039 was performed in 177 patients. Total serum 25(OH) D (n = 99) was determined by mass spectrometry. Statistical analysis was carried out using the Statistica v. 10 data analysis software (StatSoft, Russia; TIBCO, USA). Results. No differences were revealed for the frequencies of studied haplotypes between MA women and those who gave birth to healthy full-term newborns (p >0.1). No association was found between first-trimester MA and the presence of polymorphic loci variants (p >0.1). The GG haplotype of gene VDR is even less frequent in recurrent MA patients than in control (14.0% vs. 23.7%; OR = 2.29; 95% CI: 0.738–7.075). The GG haplotype of gene MTR has a 2-fold higher frequency in primary MA patients compared to control, albeit at no statistical significance (8.6 vs. 4.0%). Haplotype TT of the gene VEGF polymorphism occurs even less frequently in primary MA patients than in control (3.5 vs. 7.9%, respectively). Patients with first-trimester MA exhibited an association between vitamin D deficiency and the frequency of polymorphic variants VDR rs10735810 (p = 0.0304) and MTHFR rs1801133 (p = 0.0180). The other studied genes did not reveal such an association.Conclusion. The study demonstrates a pathogenetic association of polymorphic variants VDR rs10735810 and MTHFR rs1801133 with missed abortion and vitamin D deficiency.

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SNP rs12794714 of CYP2R1 is associated with serum vitamin D levels and recurrent spontaneous abortion (RSA): a case–control study

Cited by 3 publications

References 46 publications

Association between serum vitamin D level during pregnancy and recurrent spontaneous abortion: A systematic review and meta‐analysis

Association between serum vitamin D level during pregnancy and recurrent spontaneous abortion: A systematic review and meta‐analysis

The effect of MicroRNAs variants on idiopathic recurrent pregnancy loss

Role of polymorphic loci <i>VDR</i> rs10735810, <i>MTHFR</i> rs1801131, <i>MTHFR</i> rs1801133, <i>MTR</i> rs1805087,<i> MTRR</i> rs1801394 AND <i>VEGFA</i> rs3025039 in missed abortion: A prospective cohort study

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