SNP-detecting DNA technologies: Solving problems of applied biochemistry

Abstract

The heterozygosity of CANP3, ACTN3 , and GHR genes in specialized collections was studied using state-of-the-art DNA technologies for DNA analysis. A new dinucleotide deletion (AC) at the beginning of exon 21 was identified in five individuals with a heterozygous CANP3 gene. Analysis of polymorphism (1747 C T) of the ACTN3 gene demonstrated a positive association of allele C with high muscular performance. Real-time PCR assay of SNP1630 (A C) in the GHR gene suggested a putative negative association of allele C of this SNP with high muscular performance.