Snoring effects on the baroreflex: An animal model

Narayan, Jyotishna; Amatoury, Jason; Cho, Jin-Gun; Verma, Manisha; Kairaitis, Kristina; Wheatley, John R.; Amis, Terence C.

doi:10.1016/j.resp.2011.12.012

Cited by 8 publications

(5 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, the association of carotid artery atherosclerosis with snoring and OSA has been the subject of intense research 16 17 18 19 20 21 . In animal models, the vibratory energy of snoring sounds can be transmitted to the carotid artery inducing endothelial dysfunction and atherosclerosis 22 23 24 but does not directly alter baroreflex sensitivity 25 . In human studies, heavy snoring (>50% night snoring) may act as an independent risk factor for carotid atherosclerosis 16 .…”

mentioning

confidence: 99%

The Frequency and Energy of Snoring Sounds Are Associated with Common Carotid Artery Intima-Media Thickness in Obstructive Sleep Apnea Patients

Lee¹,

Lee

Wang

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Obstructive sleep apnea (OSA) is a known risk factor for atherosclerosis. We investigated the association of common carotid artery intima-media thickness (CCA-IMT) with snoring sounds in OSA patients. A total of 30 newly diagnosed OSA patients with no history of cardiovascular diseases were prospectively enrolled for measuring mean CCA-IMT with B-mode ultrasonography, body mass index, metabolic syndrome, 10-year cardiovascular disease risk score, high-sensitivity C-reactive protein, and homocysteine. Good-quality signals of full-night snoring sounds in an ordinary sleep condition obtained from 15 participants were further acoustically analyzed (Included group). All variables of interest were not significantly different (all p > 0.05) between the included and non-included groups except for diastolic blood pressure (p = 0.037). In the included group, CCA-IMT was significantly correlated with snoring sound energies of 0–20 Hz (r = 0.608, p = 0.036) and 652–1500 Hz (r = 0.632, p = 0.027) and was not significantly associated with that of 20–652 Hz (r = 0.366, p = 0.242) after adjustment for age and sex. Our findings suggest that underlying snoring sounds may cause carotid wall thickening and support the large-scale evaluation of snoring sound characters as markers of surveillance and for risk stratification at diagnosis.

show abstract

mentioning

confidence: 99%

The Frequency and Energy of Snoring Sounds Are Associated with Common Carotid Artery Intima-Media Thickness in Obstructive Sleep Apnea Patients

Lee¹,

Lee

Wang

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…16,17 In animal models, snoring vibration of the peri-carotid tissue induced endothelial dysfunction 18 and resulted in a depression of baroreflex sensitivity. 19 Both endothelial and autonomic dysfunctions promote carotid atherosclerosis in humans. 20,21 Kim et al reported an independent association between snoring and increased CIMT.…”

Section: Introductionmentioning

confidence: 99%

Snoring Sound Characteristics are Associated with Common Carotid Artery Profiles in Patients with Obstructive Sleep Apnea

Chuang¹,

Liu²,

Wang³

et al. 2021

NSS

View full text Add to dashboard Cite

Background: Obstructive sleep apnea (OSA) and snoring have been reported to be modifiable risk factors for thick carotid intima-media thickness (CIMT) and carotid atherosclerosis, which are closely linked to cardiovascular disease. Methods: This cross-sectional study prospectively recruited 70 participants with OSA and without a history of carotid artery disorder, who primarily sought surgical Intervention. OSA and snoring were assessed with the Epworth Sleepiness Scale, Snore Outcomes Survey, polysomnography, and snoring sound recording. The carotid arteries were evaluated with ultrasonography and divided into three types of carotid artery profiles (normal carotid artery, thick CIMT, or significant carotid atherosclerosis). Multivariate linear/logistic/categorical regressions were performed with the forward selection approaches/logistic least absolute shrinkage and selection operator, as appropriate. Results: Normalized snoring sound energy (301-850 Hz) was independently associated with the carotid intima-media thickness (regression coefficient [β] = 0.01, standard error [SE] = 0.004, P = 0.03; R 2 = 0.067) and type of carotid profile (β = 0.40, SE = 0.09, P < 0.001; R 2 = 0.156). Normalized snoring sound energy (4-300 Hz) (β = −0.10, SE = 0.04, P = 0.01) and female sex (β = 1.90, SE = 0.94, P = 0.04) were independently related to the presence of carotid stenosis (R 2 = 0.159). The optimal regression model of the type of carotid artery profile included normalized snoring sound energy (301-850 Hz) (β = 0.33, SE = 0.14, P = 0.03), snoring time (β = 0.26, SE = 0.13, P = 0.047), female sex (β = 0.26, SE = 0.13, P = 0.047), and increased age (β = 0.20, SE = 0.10, P = 0.04) under the control of the Snore Outcomes Survey score, 3% oxygen desaturation index, snoring sound energy (4-1500 Hz), normalized snoring sound energy (851-1500 Hz), cigarette smoking, and hyperlipidemia (R 2 = 0.427). Conclusion:Our findings suggested that snoring sound characteristics are associated with carotid artery profiles among early OSA patients who cannot be noticed by ultrasound because organic changes of the carotid artery have not yet started. Future studies are warranted to verify the clinical significance of the results.

show abstract

“…Loudspeakers have been used by Puig et al23 to induce cell vibration and identify airway inflammation, by Almendros et al24 to trigger upper-airway inflammation in the rat, and by Cho et al25 to vibrate the carotid arteries of rabbits. In addition, Amatoury et al11 and Narayan et al26 induced snoring by placing a sandbag over the trachea. These examples were all in vitro or short-term in vivo models.…”

Section: Discussionmentioning

confidence: 99%

Impact of Chronic Simulated Snoring on Carotid Atherosclerosis in Rabbits

et al. 2013

View full text Add to dashboard Cite

Background and PurposeChronic simulated snoring was induced in rabbits to determine the impact of snoring on the development of atherosclerosis.MethodsThe pressure wave of induced snoring at the carotid bifurcation of rabbits was acquired by gently pressing the airway. This wave was then simulated using custom-made mechanical devices. Twelve rabbits were used in this study, seven of which were assigned to the experimental group and the remaining five formed the control group. All of the rabbits were raised on a 1% high-cholesterol diet. Either working or sham devices were positioned at the ventral center of the neck in each rabbit. At the end of a 2-month observation period, all of the rabbits were sacrificed by perfusion fixation, the carotid arteries harvested, and the carotid atherosclerosis histology reviewed.ResultsAll of the rabbits survived to the end of the experimental period. Blood sampling revealed the presence of hypercholesterolemia in both groups, with no significant difference between them. The presence and degree of atherosclerosis did not differ significantly between the groups.ConclusionsThe findings of this study show the feasibility of making a chronic simulated snoring rabbit model. However, the causative role of snoring in carotid atherosclerosis was not detected in this animal study.

show abstract

Snoring effects on the baroreflex: An animal model

Cited by 8 publications

References 95 publications

The Frequency and Energy of Snoring Sounds Are Associated with Common Carotid Artery Intima-Media Thickness in Obstructive Sleep Apnea Patients

The Frequency and Energy of Snoring Sounds Are Associated with Common Carotid Artery Intima-Media Thickness in Obstructive Sleep Apnea Patients

Snoring Sound Characteristics are Associated with Common Carotid Artery Profiles in Patients with Obstructive Sleep Apnea

Impact of Chronic Simulated Snoring on Carotid Atherosclerosis in Rabbits

Contact Info

Product

Resources

About