SNORA42 promotes oesophageal squamous cell carcinoma development through triggering the DHX9/p65 axis

Shan, Yanan; Wei, Sisi; Xiang, Xiaohan; Dai, Suli; Cui, Wen-xuan; Zhao, Riyang; Zhang, Cong; Zhang, Weimin; Zhao, Lianmei; Shan, Baoen

doi:10.1016/j.ygeno.2021.06.036

Cited by 9 publications

(7 citation statements)

References 42 publications

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“…SNORA42 can act in signaling pathways, in esophageal cancer (EC) it was possible to evidence that SNORA42 is able to interact and regulate DHX9 protein expression, promote its accumulation in the nucleus and attenuate its degradation via ubiquitination. This same work evidenced that overexpression of SNORA42 was able to increase the interaction of p65 with DHX9 and influence the expression of downstream genes of the NF-κB pathway (MMP2, MMP9, VEGFC and BCL2) (Shan et al, 2021). The p65 protein is involved in different processes during tumorigenesis, favoring growth, angiogenesis, and invasion of tumor cells (Ben-Neriah and Karin, 2011).…”

Section: Nf-kb Pathway Negatively Regulated By Snora42mentioning

confidence: 77%

What is the Role of SNORA42 in Carcinogenesis? A Systematic Review

Barbosa

Matos

Silva

et al. 2023

Asian Pac J Cancer Prev

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Small nucleolar RNAs (snoRNAs) are non-coding RNAs (ncRNAs), usually located in intronic regions. SnoRNAs are classified based on their specific sequence and secondary structural characteristics (Calvo e Köhn, 2021). In addition, snoRNAs can be associated with some long non-coding RNAs (LncRNAs), such as SNHGs-small nucleolar host gene (Zhu et al., 2019).Early studies on snoRNAs reported that these molecules are present in a variety of eukaryotic organisms, being one of the most abundant groups of ncRNAs (Kiss, 2002). These ncRNAs accumulate mainly in the nucleoli, are 60-300 nucleotides (nts) in size, and are divided into three main families: C/D box (SNORDs), H/ACA box (SNORAs), and SCARNAs. The scaRNAs are localized molecules in a specialized subnuclear organelle known as

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Section: Nf-kb Pathway Negatively Regulated By Snora42mentioning

confidence: 77%

What is the Role of SNORA42 in Carcinogenesis? A Systematic Review

Barbosa

Matos

Silva

et al. 2023

Asian Pac J Cancer Prev

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“…Finally, we included a total of 49 studies in our qualitative synthesis, with 21 studies focused on diagnosis, 9 – 29 and 41 studies focused on prognosis. 11 , 13 – 15 , 17 , 18 , 20 , 22 , 24 , 25 , 27 , 28 , 30 – 56 Figure 1 provided detailing information about the selection process, which based on preferred reporting items for systematic reviews and meta-analyses (PRISMA) standards.…”

Section: Resultsmentioning

confidence: 99%

Small Nucleolar RNAs as Diagnostic and Prognostic Biomarkers in Cancer: A Systematic Review and Meta-Analysis

Gao,

Fan,

et al. 2024

Technol Cancer Res Treat

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Objectives Small nucleolar RNAs (snoRNAs) form clusters within the genome, representing a mysterious category of small non-coding RNAs. Research has demonstrated that aberrant snoRNAs can contribute to the development of various types of cancers. Recent studies have identified snoRNAs as potentially valuable biomarkers for the diagnosis or/and prognosis of cancers. However, there has been a lack of comprehensive reviews on prognostic and diagnostic snoRNAs across different types of cancers. Methods We conducted a systematic search of various databases including Google Scholar, Medline, Cochrane, Scopus, PubMed, Embase, ScienceDirect, Ovid-Medline, Chinese National Knowledge Infrastructure, WanFang, and SinoMed with a time frame reception to December 30, 2022. A total of 49 relevant articles were included in our analysis, consisting of 21 articles focusing on diagnostic aspects and 41 articles focusing on prognostic aspects. Pooled odds ratio, 95% confidence intervals (CIs), and hazard ratio (HR) were utilized to evaluate clinical parameters and overall survival (OS), respectively. Result The findings indicated that area under the curve, sensitivity, and specificity were 0.85, 75%, and 80% in cancer, respectively. There was a possibility that snoRNAs had a positive impact on the diagnosis (risk ratio, RR = 2.95, 95% CI: 2.75-3.16, P = 0.000) and OS (HR = 1) in cancer. Additionally, abnormally expressed snoRNAs were associated with a positive impact on OS time for chronic lymphocytic leukemia (HR: 0.88, 95%Cl: 0.69-1.11, P < 0.00001), colon adenocarcinoma (HR: 0.97, 95%Cl: 0.91-1.03, P < 0.0001), and ovarian cancer (HR: 0.98, 95%Cl: 0.98-0.99, P < 0.00001). However, dysregulated snoRNAs of colon cancer and colorectal cancer had a negative impact on OS time (HR = 3.01 and 1.01 respectively, P < 0.0001). Conclusion The results strongly suggested that snoRNAs could serve as potential novel indicators for prognosis and diagnosis in cancers. This systematic review followed the guidelines of the Transparent Reporting of Systematic Review and Meta-Analyses (PROSPERO register: CRD42020209096).

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“… 70 SNORA42 facilitates esophageal squamous carcinoma cell growth and metastasis by protecting DHX9 from being ubiquitinated and enhancing phosphorylation of p65 through the NF-κB pathway. 71 SNORA42 functions as an oncogene in NSCLC and knockdown of SNORA42 is associated with inhibited tumorigenicity by initiating p53-dependent apoptosis. 12 In esophageal squamous cell carcinoma, SNORD12B results in accelerated growth by activating the AKT-mTOR-4EBP1 signaling through nucleus partitioning of protein phosphatase 1 catalytic subunit alpha.…”

Section: Discussionmentioning

confidence: 99%

The Potential Role of Small Nucleolar RNAs in Cancers – An Evidence Map

Zhang

et al. 2022

IJGM

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Purpose Cancer seriously endangers human health in every country of the world. New evidence shows that small nucleolar RNAs play important roles in tumorigenesis. Herein, we created this evidence map to systematically assess the impact of dysregulated snoRNAs on cancers. Methods We searched four databases to February 2022 using the keywords, “carcinoma”, “neoplasms”, “tumor”, “cancer”, “snoRNA”, and “small nucleolar rna”. The research data were independently screened by two reviewers. Bubble plot, mind map, heatmap were used to depict the relationship between snoRNAs and cancers. Results In total, 102 studies met the inclusion criteria and were analyzed in this evidence map. In this study, we found that dysregulated snoRNAs were statistically associated with the clinicopathological characteristics of cancer patients, and affected tumor cell phenotypes. Abnormally expressed snoRNAs were associated with poor survival in cancer patients. Current research confirmed that snoRNAs have good diagnostic efficiency for cancers. snoRNAs could modulate biological processes and signaling pathways of different cancer cells by altering rRNA, regulating mRNA, and recruiting protein factors. Conclusion Taken all together, ectopic snoRNAs may serve as new biomarkers for clinical assessment, diagnostic, prognostic prediction of cancer patients, and provide a potential therapeutic strategy for cancer treatment. This article provided a visual analysis of existing evidence on snoRNAs and cancers, which can offer useful information for different researchers interested in snoRNAs.

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SNORA42 promotes oesophageal squamous cell carcinoma development through triggering the DHX9/p65 axis

Cited by 9 publications

References 42 publications

What is the Role of SNORA42 in Carcinogenesis? A Systematic Review

What is the Role of SNORA42 in Carcinogenesis? A Systematic Review

Small Nucleolar RNAs as Diagnostic and Prognostic Biomarkers in Cancer: A Systematic Review and Meta-Analysis

The Potential Role of Small Nucleolar RNAs in Cancers – An Evidence Map

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