SNMMI Procedure Standard for Scintigraphy for Differentiated Thyroid Cancer

Bartel, Twyla; Magerefteh, Samuel; Avram, Anca M.; Balon, Helena; Blanche, Lorraine E. De; Dadparvar, Simin; Johnston, Mickaila; Moreau, Shari

doi:10.2967/jnmt.120.243626

Cited by 14 publications

(15 citation statements)

References 40 publications

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“…Almost all patients included in our sample are from an outpatient setting. This is not an uncommon trend, as Tc-99m HMDP bone scintigraphy is relatively cheap and can be totally performed during an ambulatory visit, due to its short duration and low risk [17,18]. In addition, some studies suggest that both scan time and injected dose, may be reduced without jeopardizing diagnosis [19,20].…”

Section: Discussionmentioning

confidence: 99%

Radiopharmaceutical extravasation in bone scintigraphy: a cross-sectional study

Fernandes

Santos

Pinheiro

et al. 2023

Nuclear Medicine Communications

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Objetives Tc-99m Hydroxymethylene diphosphonate (HMDP) bone scintigraphy is commonly used to diagnose bone disorders. We aimed to quantify and characterize the occurrence of radiopharmaceutical extravasation in bone scintigraphy, using Tc-99m HMDP, as well as to compare the visual classification of the events with an independent analysis using image processing software. Methods We conducted a cross-sectional study, using data from a total of 400 (9.1%) exams, randomly selected from all the procedures performed in 2018 in the Portuguese Institute of Oncology of Porto, Portugal. Prevalence estimate and the corresponding 95% confidence interval (CI) was computed for the presence of extravasation. Odds ratios and 95% CI were computed to quantify the association between demographic and clinical characteristics, and the occurrence of extravasation. Results The prevalence of Tc-99m HMDP extravasation was 26.5% (95% CI: 22.4−31.0). Those from an inpatient setting had almost seven-fold higher odds of extravasation than those from an outpatient setting. When the wrist was used for administration, there was three times more odds of extravasation when compared to the use of hand. There were statistically significant differences in the median scores of extravasations severity obtained from image processing software according to the different grades attributed by visual appreciation (P < 0.001). Conclusion Tc-99m HMDP extravasation occurred in one out of four patients, being more frequent among those from an inpatient setting and when the wrist was used for administration. Visual appreciation of the extravasation seems to be acceptable to classify its severity.

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Section: Discussionmentioning

confidence: 99%

Radiopharmaceutical extravasation in bone scintigraphy: a cross-sectional study

Fernandes

Santos

Pinheiro

et al. 2023

Nuclear Medicine Communications

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“…No special patient preparation was required for bone scan. Three-phase bone scan was acquired using bone-seeking gamma-emitting radiotracer 99m Tc-MDP as per SNMMI Procedure Standard for Bone Scintigraphy 4.0 [4]. Approximately 740–925 MBq (20–25 mCi) of Tc-99m MDP was administered intravenously to adult patients.…”

Section: Methodsmentioning

confidence: 99%

Comparison of bone SPECT/CT and MRI in detection of pain generator in ankle and foot pain: a retrospective diagnostic study

Agrawal

Swaroop

Patro

et al. 2021

Nuclear Medicine Communications

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Objective To study the sensitivity and specificity of MRI and bone SPECT-CT in detecting the pain generator in ankle and foot pain with diagnostic dilemma. Methods Retrospectively data of patients with ankle or foot pain who underwent both MRI and Bone SPECT-CT were analyzed. The lesions and probable pain generator sites were reported as per MRI and bone SPECT-CT findings. These lesions were correlated clinically, managed accordingly and followed up. The patients who had significant improvement in response to the treatment provided were considered to have been diagnosed accurately. The foot and ankle disability index (FADI) was used to evaluate the patient’s pre- and postintervention condition. Results The study included 37 patients retrospectively (18 women and 19 men). The lesions were classified into soft tissue lesions (ligaments/tendons), joint lesions (arthritis) and bony lesions (fractures/osteomyelitis/osteochondral lesions). Overall, MRI had sensitivity, specificity, positive predictive value and negative predictive value of 82, 31, 74 and 42%, respectively, and SPECT-CT had sensitivity, specificity, positive predictive value and negative predictive value of 84, 60, 84 and 60%, respectively. The mean FADI score pretreatment for all patients was 61.5 (SD = 13.8) and posttreatment 88.4 (SD = 13.01) showing significant improvement in the score (P < 0.05), suggesting that the final diagnosis of these patients was accurate. Overall, management change due to bone SPECT-CT over MRI was seen in 26% of patients. Conclusion Bone SPECT-CT has incremental value over MRI in the diagnosis of pain generator in foot and ankle pain. The overall specificity of bone SPECT-CT is higher than MRI in detection of pain generators. Bone SPECT-CT performed better than MRI in detection of culprit pathology in the bone, whereas MRI is better in soft tissue lesions. Advances in knowledge There are only a few published literature with direct comparison of bone SPECT-CT scintigraphy and MRI in detection of foot and ankle pain generator. This study directly compares diagnostic utility of bone SPECT-CT scintigraphy and MRI in foot and ankle pain. In the present study, the bone SPECT-CT performed better than MRI in detection of culprit pathology in the bone, whereas MRI is better in soft tissue lesions.

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“…The identification and localization of uptake foci may be enhanced by a concomitant single‐photon emission computed tomography/computed tomography (SPECT/CT) scan 8 . Diagnostic whole‐body scans (WBS) are acquired 1–3 days after RAI administration, whereas post‐RAI treatment images can be obtained 2–7 days after treatment 29 …”

Section: Nuclear Medicine Perspectivementioning

confidence: 99%

“…As discussed above, nuclear medicine physicians are divided about the need for postoperative diagnostic low‐activity radioiodine (1–3 mCi; 131 I or 123 I) WBS 29 . If there were no remnants or other foci of iodine‐avid tissue on the scan, then giving radioiodine would not be indicated; however, in high‐risk patients, RAI treatment of occult metastases may be warranted 29 . In our patient, the diagnostic scan was performed given the risk factors of muscle invasion and multiple nodal metastases.…”

Section: Nuclear Medicine Perspectivementioning

confidence: 99%

“…8 Diagnostic whole-body scans (WBS) are acquired 1-3 days after RAI administration, whereas post-RAI treatment images can be obtained 2-7 days after treatment. 29 The routine use of a preablation or diagnostic WBS with SPECT/ CT is controversial, and there continues to be discussion on the utility of postoperative RAI diagnostic scanning (with or without SPECT/CT) in guiding RAI therapeutic decision making. According to the ATA, WBS may be useful when the extent of the thyroid remnant or residual disease cannot be accurately ascertained from the surgical report or neck ultrasonography and when the results may alter the decision to treat or the activity of RAI that is to be administered.…”

Section: Nuclear Medicine Perspectivementioning

confidence: 99%

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