Sneddon-Wilkinson Disease Induced by Sorafenib in a Patient with Advanced Hepatocellular Carcinoma

Tajiri, Kazuto; Nakajima, Takahiko; Kawai, Kengo; Minemura, Masami; Sugiyama, Toshiro

doi:10.2169/internalmedicine.54.3675

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…These cases involved a multikinase inhibitor [40] and a TNF-a inhibitor [41]. Sorafenib, a multikinase inhibitor, is used to treat several malignancies, including renal cell carcinoma, hepatocellular carcinoma, and thyroid carcinoma.…”

Section: Drug Reactionsmentioning

confidence: 99%

“…Several cutaneous toxicities have occurred with sorafenib, reportedly in 92 % of patients within 6 weeks of treatment [42]. These included squamous cell carcinoma, psoriasiform eruptions, hand-foot skin reaction (HFSR), erythema, alopecia, Stevens-Johnson syndrome (SJS), keratoacanthomas, actinic keratosis, and a case of SPD [40,42,43]. The patient, described by Tajiri et al [40], had been diagnosed with a hepatocellular carcinoma 7 years previously and treated with radiofrequency ablation and transarterial chemoembolization.…”

Section: Drug Reactionsmentioning

confidence: 99%

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Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

2016

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Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare, benign yet relapsing pustular dermatosis. Its incidence and prevalence have not been well studied. It characteristically presents as hypopyon pustules on the trunk and intertriginous areas of the body. SPD is similar to two other disease entities. Both SPD-type immunoglobulin (Ig)-A pemphigus and annular pustular psoriasis clinically and histologically present similarly to SPD. Immunologic studies separate SPD-type IgA pemphigus from SPD and pustular psoriasis. However, there is still an unclear designation as to whether SPD is its own entity distinct from pustular psoriasis, as the once thought characteristic histologic picture of psoriasis does not hold true for pustular psoriasis. SPD has been reported to occur in association with several neoplastic, immunologic, and inflammatory conditions. Dapsone remains the first-line treatment for SPD, although dapsone-resistant cases have been increasingly reported. Other therapies have been used singly or as adjunctive therapy with success, such as corticosteroids, immunosuppressive agents, tumor necrosis factor inhibitors, and ultraviolet light therapy. This article provides a review of the last 30 years of available literature, with a focus on successful treatment options and a suggestion for reappraisal of the classification of SPD.

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Section: Drug Reactionsmentioning

confidence: 99%

Section: Drug Reactionsmentioning

confidence: 99%

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

2016

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“…However, immunological disturbance resulting from the abnormal cytokine profile has been generally accepted as the underlying cause. The isolation of neutrophil chemoattractants in pustule contents of SPD cases supports this opinion [ 5 , 7 ]. Over-activation of neutrophils is thought to cause neutrophil accumulation and destruction in the tissue.…”

Section: Discussionmentioning

confidence: 71%

“…Acantholytic cells and eosinophils may be seen in the pustule. Minimal spongiosis or in some cases acantholysis may occur [ 1 – 5 ]. Direct immunofluorescence analysis is negative.…”

Section: Discussionmentioning

confidence: 99%

A child with subcorneal pustular dermatosis responded to IVIG treatment (Sneddon-Wilkinson disease)

et al. 2017

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Subcorneal pustular dermatosis (SPD) is a rare, chronic, recurrent dermatosis characterised by sterile pustules. It develops mainly in middle-aged or elder women, but is also rarely seen in children. The exact aetiology of the disease is unknown. In literature, cases associated with IgA gammopathy have been reported. In this article; we report a case of a five-year-old girl who was diagnosed as SPD by clinical features, histopathological characteristics, and direct immunofluorescence analysis results. IgA was high, and IgG-IgM and CD19+ B cell were low. We noticed that during IVIG treatment for immunodeficiency, dermatological symptoms were recovered rapidly. Clinical profile of SPD and its association with systemic diseases may provide early detection of immune dysfunction.

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“…Although a plethora of inhibitors have been developed and utilized to treat HCC, suitable drugs for liver cancer therapy are needed because overall survival rates of patients with liver cancer remain low. For example, sorafenib is the standard treatment for advanced HCC, but there are many side effects to be solved, such as subcorneal pustular dermatosis ( 39 ). Furthermore, cancerous cells occasionally circumvent drug targeted signaling by adapting to diverse environments, which is linked to poor patient prognosis ( 40 ).…”

Section: Hdacs In Human Cancersmentioning

confidence: 99%

Histone Deacetylases and Their Regulatory MicroRNAs in Hepatocarcinogenesis

2015

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A growing body of evidence suggests that epigenetic modifications are promising potential mechanisms in cancer research. Among the molecules that mediate epigenetic mechanisms, histone deacetylases (HDACs) are critical regulators of gene expression that promote formation of heterochromatin by deacetylating histone and non-histone proteins. Aberrant regulation of HDACs contributes to malignant transformation and progression in a wide variety of human cancers, including hepatocellular carcinoma (HCC), gastric cancer, lung cancer, and other cancers. Thus, the roles of HDACs have been extensively studied because of their potential as therapeutic targets. However, the underlying mechanism leading to deregulation of individual HDACs remains largely unknown. Some reports have suggested that functional microRNAs (miRNAs) modulate epigenetic effector molecules including HDACs. Here, we describe the oncogenic or tumor suppressive functions of HDAC families and their regulatory miRNAs governing HDAC expression in hepatocarcinogenesis.Graphical Abstract

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Sneddon-Wilkinson Disease Induced by Sorafenib in a Patient with Advanced Hepatocellular Carcinoma

Cited by 13 publications

References 24 publications

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

A child with subcorneal pustular dermatosis responded to IVIG treatment (Sneddon-Wilkinson disease)

Histone Deacetylases and Their Regulatory MicroRNAs in Hepatocarcinogenesis

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