SND-117, a sinomenine bivalent alleviates type II collagen-induced arthritis in mice

Zhou, Yilong; Zhao, Yue; Bao, Beihua; Li, Jianxin

doi:10.1016/j.intimp.2015.04.006

Cited by 22 publications

(6 citation statements)

References 48 publications

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“…Y.R. Zhou et al (2015) reported that SIN divalent SND-117 (27) significantly mitigated erythema and swelling in mice, reduced bone erosion and joint destruction, and decreased IL-1β, IL-6, and TNF-α in the knee, besides inhibiting NF-κB-p65. SND-117 also inhibited TNF-α-induced IL-1β and IL-6 expression in a non-cytotoxic concentration range of 2-10 µM [144].…”

Section: Anti-inflammatory Activity and Analgesic Activity Of Compoun...mentioning

confidence: 99%

Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review

Hou,

Huang,

Huang

et al. 2024

Molecules

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Sinomenine, an isoquinoline alkaloid extracted from the roots and stems of Sinomenium acutum, has been extensively studied for its derivatives as bioactive agents. This review concentrates on the research advancements in the biological activities and action mechanisms of sinomenine-related compounds until November 2023. The findings indicate a broad spectrum of pharmacological effects, including antitumor, anti-inflammation, neuroprotection, and immunosuppressive properties. These compounds are notably effective against breast, lung, liver, and prostate cancers, exhibiting IC50 values of approximately 121.4 nM against PC-3 and DU-145 cells, primarily through the PI3K/Akt/mTOR, NF-κB, MAPK, and JAK/STAT signaling pathways. Additionally, they manifest anti-inflammatory and analgesic effects predominantly via the NF-κB, MAPK, and Nrf2 signaling pathways. Utilized in treating rheumatic arthritis, these alkaloids also play a significant role in cardiovascular and cerebrovascular protection, as well as organ protection through the NF-κB, Nrf2, MAPK, and PI3K/Akt/mTOR signaling pathways. This review concludes with perspectives and insights on this topic, highlighting the potential of sinomenine-related compounds in clinical applications and the development of medications derived from natural products.

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Section: Anti-inflammatory Activity and Analgesic Activity Of Compoun...mentioning

confidence: 99%

Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review

Hou,

Huang,

Huang

et al. 2024

Molecules

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“…Fan et al encapsulated sinomenium into chitosan particles [63]. Sinomenium is a natural alkaloid that has been shown to modulate NF-κB signaling, down-regulate MMP-13 expression, and regulate autophagy, a protective mechanism in normal joints [126,127]. The particles were prepared by a water-in-oil (w/o) emulsion process (figure 4(A)), in which the drug was combined with chitosan in the aqueous phase, and then the chitosan was crosslinked using glutaraldehyde.…”

Section: Chitosanmentioning

confidence: 99%

Polymer particles for the intra-articular delivery of drugs to treat osteoarthritis

et al. 2021

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Osteoarthritis (OA) is a leading cause of chronic disability. It is a progressive disease, involving pathological changes to the entire joint, resulting in joint pain, stiffness, swelling, and loss of mobility. There is currently no disease-modifying pharmaceutical treatment for OA, and the treatments that do exist suffer from significant side effects. An increasing understanding of the molecular pathways involved in OA is leading to many potential drug targets. However, both current and new therapies can benefit from a targeted approach that delivers drugs selectively to joints at therapeutic concentrations, while limiting systemic exposure to the drugs. Delivery systems including hydrogels, liposomes, and various types of particles have been explored for intra-articular drug delivery. This review will describe progress over the past several years in the development of polymer-based particles for OA treatment, as well as their in vitro, in vivo, and clinical evaluation. Systems based on biopolymers such as polysaccharides and polypeptides, as well as synthetic polyesters, poly(ester amide)s, thermoresponsive polymers, poly(vinyl alcohol), amphiphilic polymers, and dendrimers will be described. We will discuss the role of particle size, biodegradability, and mechanical properties in the behavior of the particles in the joint, and the challenges to be addressed in future research.

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“…1). [30][31][32] Introducing amino acid group into the drug molecule could enhance its anti-tumor and anti-inammatory activity and increase its solubility. 33,34 Meanwhile, nitrogenbased heterocycles in the drug design are almost 60% of unique small-molecule drugs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory and analgesic agent

et al. 2022

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SND-117, a sinomenine bivalent alleviates type II collagen-induced arthritis in mice

Cited by 22 publications

References 48 publications

Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review

Bioactivities and Mechanisms of Action of Sinomenine and Its Derivatives: A Comprehensive Review

Polymer particles for the intra-articular delivery of drugs to treat osteoarthritis

Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory and analgesic agent

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