SNCA alleles rs356219 and rs356165 are associated with Parkinson’s disease and increased α-synuclein gene expression in CD45+ blood cells

Anton, Emil; Andoskin, P.; Miliukhina, Irina; Timofeeva, A. A.; Yakimovskii, A. F.; Senkevich, Konstantin; Николаев, Михаил; Pchelina, Sofya

doi:10.1134/s1990519x16040064

Cited by 1 publication

(2 citation statements)

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“…They also found a significant correlation with early age at onset of PD, highlighting rs356165 as an important risk factor for PD. Emelyanov confirmed that G alleles of rs356165 are associated with increased risk of PD development [ 22 ]. Both the level of mRNA SNCA gene and that of α-synuclein protein were increased in rs356165 carriers compared to carriers with AA genotype in control group ( p = 0.046 and p = 0.039, respectively) [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Emelyanov confirmed that G alleles of rs356165 are associated with increased risk of PD development [ 22 ]. Both the level of mRNA SNCA gene and that of α-synuclein protein were increased in rs356165 carriers compared to carriers with AA genotype in control group ( p = 0.046 and p = 0.039, respectively) [ 22 ]. As can be seen from the above, numerous studies showed a strong association of the rs356165 variant with sporadic form of PD, although the results are not entirely consistent.…”

Section: Discussionmentioning

confidence: 99%

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SNCA 3′ UTR Genetic Variants in Patients with Parkinson’s Disease

2021

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The SNCA (Synuclein Alpha) gene represents a major risk gene for Parkinson’s disease (PD) and SNCA polymorphisms have been associated with the common sporadic form of PD. Numerous Genome-Wide Association Studies showed strong signals located in the SNCA 3′ UTR (untranslated region) region indicating that variants in 3′ UTRs of PD-associated genes could contribute to neurodegeneration and may regulate the risk for PD. Genetic variants in 3′ UTR can affect miRNA activity and consequently change the translation process. The aim of this study was to access the differences in 3′ UTR variants of SNCA genes in a cohort of PD patients and control subjects from Croatia. The cohort consisted of 52 PD patients and 23 healthy control subjects. Differences between 3′UTR allele and genotype frequencies were accessed through next generation sequencing approach from whole blood samples. In our study, we identified four previously reported single nucleotide polymorphisms (SNPs) and one insertion in the 3′ UTR region of SNCA gene, namely rs1045722, rs3857053, rs577490090, rs356165, and rs777296100, and five variants not reported in the literature, namely rs35270750, rs529553259, rs377356638, rs571454522, and rs750347645. Our results indicate a significantly higher occurrence of the rs571454522 variant in the PD population. To the best of our knowledge, this variant has not been reported until now in the literature. We analyzed our results in the context of previous research, creating a brief overview of the importance of 3′ UTR variants of the SNCA gene. Further studies will be needed to gain a more profound insight regarding their role in PD development, which will help to assess the role and impact of post-transcriptional regulation on disease pathology.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%