Snapshot of Quantiferon TB gold testing in Northern Mexico

González-Salazar, Francisco; Vargas‐Villarreal, Javier; Garcialuna-Martínez, F.J.; Rivera, G Hermelinda; Moreno-Treviño, María Guadalupe; Montfort-Gardeazabal, Jorge M.; Garcialuna-Martínez, E.

doi:10.1016/j.tube.2011.10.007

Cited by 12 publications

(13 citation statements)

References 19 publications

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“…As per the authors’ prior results from the Mexico side of the border, we found the TST and QFT-GIT to show a low level of overall concordance [18, 31]. Eight participants who had positive TST results (33 %) were negative on QFT-GIT.…”

Section: Discussionsupporting

confidence: 71%

“…If we consider a positive result with either test to indicate LTBI, our findings of approximately half of the sample testing positive (55 %) is much higher than that previously published in the general population in the US (5 %) as well as a relatively high estimate, when compared with existing border and migrant estimates on the US and Mexico border regions of between 30–40 % [18, 28, 30, 31]. Low socioeconomic status in other US populations has previously been linked to increased rates of TB disease transmission (and while unmeasured, new infections) [26].…”

Section: Discussioncontrasting

confidence: 55%

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Detection of latent tuberculosis infection among migrant farmworkers along the US-Mexico border

et al. 2016

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BackgroundMigrant farmworkers are among the highest-risk populations for latent TB infection (LTBI) in the United States with numerous barriers to healthcare access and increased vulnerability to infectious diseases. LTBI is usually diagnosed on the border using the tuberculin skin test (TST). QuantiFERON-TB Gold In-Tube (QFT-GIT) also measures immune response against specific Mycobacterium tuberculosis antigens. The objective of this study is to assess the comparability of TST and QFT-GIT to detect LTBI among migrant farmworkers on the border, as well as to examine the effects of various demographic and clinical factors on test positivity.MethodsParticipants were recruited using mobile clinics on the San Luis US-Mexico border and tested with QFT-GIT and TST. Demographic profiles and clinical histories were collected. Kappa coefficients assessed agreement between TST and QFT-GIT using various assay cutoffs. Logistic regression examined factors associated with positive TST or QFT-GIT results.ResultsOf 109 participants, 59 of 108 (55 %) were either TST (24/71, 34 %) or QFT-GIT (52/106, 50 %) positive. Concordance between TST and QFT-GIT was fair (71 % agreement, ĸ = 0.38, 95 % CI: 0.15, 0.61). Factors associated with LTBI positivity included smoking (OR = 1.26, 95 % CI–1.01–1.58) and diabetes/high blood sugar (OR = 0.70, 95 % CI = 0.51–0.98).DiscussionTest concordance between the two tests was fair, with numerous discordant results observed. Greater proportion of positives detected using QFT-GIT may help avoid LTBI under-diagnosis. Assessment of LTBI status on the border provides evidence whether QFT-GIT should replace the TST in routine practice, as well as identifies risk factors for LTBI among migrant populations.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-016-1959-3) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 71%

Section: Discussioncontrasting

confidence: 55%

Detection of latent tuberculosis infection among migrant farmworkers along the US-Mexico border

et al. 2016

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“…LTBI is a condition that is difficult to diagnose because many patients host the bacillus in a latent stage without symptoms of tuberculosis (TB) disease (after contact with Mycobacterium tuberculosis ) [2, 3]. Associated with this condition is the high risk of reactivation of the infection, which can occur during a change in the immunological status of the patient, such as reduced immunity caused by immunosuppressive therapies [4].…”

Section: Introductionmentioning

confidence: 99%

Dynamic QuantiFERON Response in Psoriasis Patients Taking Long-Term Biologic Therapy

Drago

Nicola

Signori

et al. 2013

Dermatol Ther (Heidelb)

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IntroductionThe risk of active tuberculosis is increased in psoriasis patients receiving biologic drug therapy. The QuantiFERON-TB Gold In-Tube assay (QFT) is used for latent tuberculosis screening in these patients. This study presents a retrospective analysis on repeated QFT assays, investigating the influence of biologic drugs and isoniazid therapy on the outcome of the assay.MethodsSerial QFTs of 58 psoriasis patients, who received biologic drug therapy, were evaluated at baseline and after 12 months of treatment. Patients were retrospectively divided in four groups according to QFT results at baseline and at follow-up: patients having a QFT reversion (from positive to negative results); patients with a conversion (from negative to positive); patients confirming the baseline results, either positive or negative.ResultsAt the end of the 12-months period, 11.1% of patients with a negative QFT result at baseline presented a conversion, showing low interferon (IFN)-gamma values, whereas 6.9% of positive patients presented a QFT reversion. When the test was repeated after 2–3 months without isoniazid chemoprophylaxis, patients with QFT conversion showed negative results. No patient developed active tuberculosis.ConclusionsIn patients undergoing biologic therapy, a positive QFT assay needs to be further confirmed, as false-positive results may occur after long-term therapy. Repeating QFT tests in patients with low IFN-gamma values could reduce the incidence of false-positive latent tuberculosis infection diagnosis, thus preventing unnecessary tuberculosis chemoprophylaxis. In conclusion, a dynamic QFT response is possible in psoriasis patients undergoing biologic therapy.

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“…[9][10][11] En México, el método ha mostrado ser válido en poblaciones confinadas, 12 además de ser costo-eficaz para el diagnóstico de la tuberculosis en adultos. 13 Poco se conoce acerca de su valor en niños mexicanos aunque ha mostrado su utilidad para el diagnóstico de tuberculosis latente 14 y, recientemente, en migrantes que residen en Estados Unidos.…”

Section: Discussionunclassified

Utilidad de los ensayos de liberación de interferón gamma para la detección de tuberculosis en población pediátrica

et al. 2015

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El ensayo de liberación de interferón gamma es un método novedoso para el diagnóstico de la tuberculosis aunque su utilidad es incierta en población pediátrica.Objetivo: examinar la utilidad diagnóstica del QuantiFERON-TB Gold (QFT-G®), uno de los ensayos de liberación de interferón gamma comerciales, en población pediátrica del Estado de Sonora, México.Materiales y métodos: estudio transversal con 160 menores de 19 años de edad, en un hospital de Sonora, México. Se compararon tres grupos, uno de pacientes con tuberculosis activa, otro con tuberculosis latente y uno más de controles hospitalizados. Los criterios de Stegen-Toledo fueron el estándar empleado. Se usó regresión logística multivariada para evaluar la asociación entre el QFT-G® y los predictores seleccionados.Resultados: la sensibilidad del QFT-G® en la tuberculosis activa fue de 76.9% y la especificidad de 90.3%. Para la tuberculosis latente la sensibilidad fue 25.0% y la especificidad de 98.6%. El QFT-G® mostró una concordancia moderada (K = 0.574) con el estándar. También mostró asociación con la radiografía de tórax sugestiva de tuberculosis (razón de momios ajustada 4.37, IC 95%: 1.42, 13.42) y con el hecho de ser caso de tuberculosis pulmonar (razón de momios ajustada 6.15, IC 95%: 1.90, 19.92).Conclusión: el ensayo de liberación de interferón gamma es un método útil para diagnosticar tuberculosis activa y puede emplearse para descartar tuberculosis latente en población pediátrica.

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Snapshot of Quantiferon TB gold testing in Northern Mexico

Cited by 12 publications

References 19 publications

Detection of latent tuberculosis infection among migrant farmworkers along the US-Mexico border

Detection of latent tuberculosis infection among migrant farmworkers along the US-Mexico border

Dynamic QuantiFERON Response in Psoriasis Patients Taking Long-Term Biologic Therapy

Utilidad de los ensayos de liberación de interferón gamma para la detección de tuberculosis en población pediátrica

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