SnapShot: Eukaryotic ribosome biogenesis I

Hurt, Ed; Cheng, Jingdong; Baβler, Jochen; Iwasa, Janet; Beckmann, Roland

doi:10.1016/j.cell.2023.04.030

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, they belong to nucleolar DNA, which is comprised – besides rDNA and these sequences – of specific nucleolus-associated chromosomal domains [ 7 , 8 ]. As a result of pre-rRNA synthesis and processing, the nucleolar space is largely filled with 90S pre-ribosomal RNP particles at varying stages of maturation [ 9 ]. The molecular assemblies associated with the early steps of ribosome biogenesis define distinct nucleolar territories, namely the fibrillar center (FC), the dense fibrillar component (DFC) and the granular component (GC).…”

Section: Introductionmentioning

confidence: 99%

Beyond ribosome biogenesis: noncoding nucleolar RNAs in physiology and tumor biology

Böğürcü-Seidel,

Ritschel,

Acker

et al. 2023

Nucleus

View full text Add to dashboard Cite

The nucleolus, the largest subcompartment of the nucleus, stands out from the nucleoplasm due to its exceptionally high local RNA and low DNA concentrations. Within this central hub of nuclear RNA metabolism, ribosome biogenesis is the most prominent ribonucleoprotein (RNP) biogenesis process, critically determining the structure and function of the nucleolus. However, recent studies have shed light on other roles of the nucleolus, exploring the interplay with various noncoding RNAs that are not directly involved in ribosome synthesis. This review focuses on this intriguing topic and summarizes the techniques to study and the latest findings on nucleolar long noncoding RNAs (lncRNAs) as well as microRNAs (miRNAs) in the context of nucleolus biology beyond ribosome biogenesis. We particularly focus on the multifaceted roles of the nucleolus and noncoding RNAs in physiology and tumor biology.

show abstract

Section: Introductionmentioning

confidence: 99%