Snakebites and ethnobotany in the Eastern region of Antioquia, Colombia—The traditional use of plants

Vásquez, Julieta; Jiménez, Silvia; Gómez, Isabel; Rey, Jessica P.; Henao, Ana María Celis; Marín, Daniela M.; Romero, Juan Fernando Cano; Braga, Juan C.

doi:10.1016/j.jep.2012.12.043

Cited by 37 publications

(22 citation statements)

References 28 publications

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“…The rapid effect of the toxins in the venom results in high mortality (5%) and serious long-term effects (6%). The healers and shamans administer plant extracts to neutralize the toxins such as phospholipase A2 present in the venom, where S. dulcis was identified as one of the plants being used for this purpose [21]. In Sri Lanka, rice based porridges containing herbal extracts and coconut milk have been traditionally consumed for breakfast.…”

Section: Ethnomedicinementioning

confidence: 99%

Antidiabetic Properties, Bioactive Constituents, and Other Therapeutic Effects of Scoparia dulcis

Pamunuwa

Karunaratne

Waisundara

2016

Evidence-Based Complementary and Alternative Medicine

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This review discusses the antidiabetic activities of Scoparia dulcis as well as its antioxidant and anti-inflammatory properties in relation to the diabetes and its complications. Ethnomedical applications of the herb have been identified as treatment for jaundice, stomach problems, skin disease, fever, and kidney stones, reproductory issues, and piles. Evidence has been demonstrated through scientific studies as to the antidiabetic effects of crude extracts of S. dulcis as well as its bioactive constituents. The primary mechanisms of action of antidiabetic activity of the plant and its bioactive constituents are through α-glucosidase inhibition, curbing of PPAR-γ and increased secretion of insulin. Scoparic acid A, scoparic acid D, scutellarein, apigenin, luteolin, coixol, and glutinol are some of the compounds which have been identified as responsible for these mechanisms of action. S. dulcis has also been shown to exhibit analgesic, antimalarial, hepatoprotective, sedative, hypnotic, antiulcer, antisickling, and antimicrobial activities. Given this evidence, it may be concluded that S. dulcis could be promoted among the masses as an alternative and complementary therapy for diabetes, provided further scientific studies on the toxicological and pharmacological aspects are carried out through either in vivo or clinical means.

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Section: Ethnomedicinementioning

confidence: 99%

Antidiabetic Properties, Bioactive Constituents, and Other Therapeutic Effects of Scoparia dulcis

Pamunuwa

Karunaratne

Waisundara

2016

Evidence-Based Complementary and Alternative Medicine

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“…It is estimated that 400,000 people are left with permanent disabilities after snakebites [22, 23, 26]. In this scenario, the search for new complementary therapies to treat snakebites is relevant and medicinal plants could be highlighted as a rich source of natural inhibitors and pharmacologically active compounds [33, 34]. A significant number of plants have been evaluated for their potential inhibitory activity of Bothrops venoms [5, 33, 34, 35, 36, 37].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Hydroethanolic Leaf Extracts of Kalanchoe brasiliensis and Kalanchoe pinnata (Crassulaceae) against Local Effects Induced by Bothrops jararaca Snake Venom

et al. 2016

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The species Kalanchoe brasiliensis and Kalanchoe pinnata, both known popularly as “Saião,” are used interchangeably in traditional medicine for their antiophidic properties. Studies evaluating the anti-venom activity of these species are scarce. This study aims to characterize the chemical constituents and evaluate the inhibitory effects of hydroethanolic leaf extracts of K. brasiliensis and K. pinnata against local effects induced by Bothrops jararaca snake venom. Thin Layer Chromatography (TLC) and High Performance Liquid Chromatography coupled with Diode Array Detection and Electrospray Mass Spectrometry (HPLC-DAD-MS/MS) were performed for characterization of chemical markers of the extracts from these species. For antiophidic activity evaluation, B. jararaca venom-induced paw edema and skin hemorrhage in mice were evaluated. In both models, hydroethanolic extracts (125–500 mg/kg) were administered intraperitoneally in different protocols. Inhibition of phospholipase enzymatic activity of B. jararaca was evaluated. The HPLC-DAD-MS/MS chromatographic profile of extracts showed some particularities in the chemical profile of the two species. K. brasileinsis exhibited major peaks that have UV spectra similar to flavonoid glycosides derived from patuletin and eupafolin, while K. pinnata showed UV spectra similar to flavonoids glycosides derived from quercetin and kaempferol. Both extracts significantly reduced the hemorrhagic activity of B. jararaca venom in pre-treatment protocol, reaching about 40% of inhibition, while only K. pinnata was active in post-treatment protocol (about 30% of inhibition). In the antiedematogenic activity, only K. pinnata was active, inhibiting about 66% and 30% in pre and post-treatment protocols, respectively. Both extracts inhibited phospholipase activity; however, K. pinnata was more active. In conclusion, the results indicate the potential antiophidic activity of Kalanchoe species against local effects induced by B. jararaca snake venom, suggesting their potential use as a new source of bioactive molecules against bothropic venom.

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“…The search for new inhibitors of isolated toxins and snake venoms is essential to complement or even to replace serotherapy, because this type of therapy is not very effective in neutralizing the local effects observed after snakebites and it is not very accessible to high-risk areas. The popular use of medicinal plants for the treatment of snakebites has been consecrated because they have a broad spectrum of effects 6,7,8,9,10 . This fact emphasizes the economic and medical importance of ethnopharmacological studies that evaluate the therapeutic properties of plant species.…”

Section: Introductionmentioning

confidence: 99%

“…Proteases (serine and metalloproteinases) are the principal enzymes responsible for these activities, being involved in the induction of necrosis and hemorrhage 2,8,10,11,12,13 . 13 .…”

Section: Introductionmentioning

confidence: 99%

Clotting and fibrinogenolysis inhibition by essential oils from species of the Asteraceae family

Miranda

Cardoso

Marcussi

et al. 2016

Braz. arch. biol. technol.

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Snakebites and ethnobotany in the Eastern region of Antioquia, Colombia—The traditional use of plants

Cited by 37 publications

References 28 publications

Antidiabetic Properties, Bioactive Constituents, and Other Therapeutic Effects of Scoparia dulcis

Antidiabetic Properties, Bioactive Constituents, and Other Therapeutic Effects of Scoparia dulcis

Inhibitory Effects of Hydroethanolic Leaf Extracts of Kalanchoe brasiliensis and Kalanchoe pinnata (Crassulaceae) against Local Effects Induced by Bothrops jararaca Snake Venom

Clotting and fibrinogenolysis inhibition by essential oils from species of the Asteraceae family

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