Snakebite-Associated Kidney Injury

Albuquerque, Polianna Lemos Moura Moreira; Mota, Sandra Mara Brasileiro

doi:10.1159/000517725

Cited by 3 publications

(1 citation statement)

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“…Organ dysfunction frequently occurs in snakebite cases. Previous studies have extensively reported the poor outcomes after snakebite, including circulation dysfunction with hemodynamic instability, respiratory dysfunction, renal dysfunction, hepatic dysfunction, thrombocytopenia, and nervous system dysfunction (5,(16)(17)(18)(19)(20)(21)(22). Rapid venoms released into the bloodstream and interaction with major organs plays a signi cant role in snakebites, leading to infection, in ammation, neurotoxicity, and damage to musculoskeletal, respiratory, renal, liver, cardiovascular, and coagulation systems (23).…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of red blood cell width distribution-to-platelet ratio in patients with snakebite-associated multiple organ dysfunction syndrome：A retrospective observational study

Liang,

Xing,

Zhuang

et al. 2023

Preprint

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Background: Snakebite-induced organ dysfunction emerging as the primary determinant of morbidity and mortality. This study aims to evaluate the prognostic relevance of multiple organ dysfunction syndrome (MODS) after snakebites. Methods: A retrospective study included 637 patients with snakebite between 2015 and 2020 from two hospitals in Anhui province, China. Data were collected at two time points: on the 1st-day and the 5th-day after treatment. All patients were divided into two groups according to the presence or absence of MODS. T-tests, chi-square tests, and univariate and multivariate logistical analyses were used to identify the prognostic factors for the development of MODS. Results: 56 (8.8%) patients developed MODS following snakebite. Logistics analyses indicated that from being bitten at the hospital, the 1st-day of red blood cell distribution width-to-platelet ratio (RPR) and creatinine (CR) levels, and the 5th-day of aspartate aminotransferase (AST) were significantly associated with the development of MODS. The sensitivity and the specificity of the 1st-day RPR were calculated by the received operating characteristic curve (AUC=0.720, 95%CI, 0.642-0.798). The 1st day RPR=0.110 and the 5th day RPR=0.085. Conclusion: The 1st-day RPR ＞0.110 is prone to be a new independent predictive factor for the development of MODS after snakebite.

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