Snake Venoms and Nephrotoxicity

Sitprija, Visith; Boonpucknavig, Vijitr

doi:10.1007/978-3-642-66913-2_28

Cited by 20 publications

(13 citation statements)

References 27 publications

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“…In our study, out of total number of snake bite patients, 20.48% patients developed acute renal failure. This prevalence is similar to the other studies from India [4,[12][13][14][15][16][17][18][19][20][21][22]; whereas the prevalence of acute renal failure in snake bite in studies from Nigeria, Israel, Thailand and Southeast Anatolia has been found to be 1-10%, 6.2%, 5% and 8% respectively [23][24][25][26]. The higher prevalence probably suggests delay in administration of ASV, as there is a delay in taking the patient to hospital after snake bite, which may be related to social factors, and the long distances that the tribal and rural people have to travel before reaching a health facility.…”

Section: Discussionsupporting

confidence: 87%

Snake Bite Induced Acute Renal Failure: A Study of Clinical Profile and Predictors of Poor Outcome

Patil

2012

World J Nephrol Urol

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Section: Discussionsupporting

confidence: 87%

Snake Bite Induced Acute Renal Failure: A Study of Clinical Profile and Predictors of Poor Outcome

Patil

2012

World J Nephrol Urol

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“…This prevalence is similar to the other studies from India; [4,[12][13][14][15][16][17][18][19][20][21][22] whereas the prevalence of acute renal failure in snake bite in studies from Nigeria, Israel, Thailand, and South-east Anatolia has been found to be 1-10%, 6.2%, 5%, and 8%, respectively. [23][24][25][26] The higher prevalence probably suggests delay in administration of ASV as there is a delay in taking the patient to hospital after snake bite, which may be related to social factors, and the long distances that the tribal and rural people have to travel before reaching a health facility.…”

Section: Discussionmentioning

confidence: 96%

Snake bite-induced acute renal failure: A study of clinical profile and predictors of poor outcome

Patil¹,

Bansod²

2012

Ann Trop Med Public Health

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Aims: Acute renal failure is an important cause of morbidity and mortality in snake bite patients, especially in tropical countries. This study was aimed to describe clinical profile and to identify predictors of poor outcome in snake bite-induced acute renal failure. Settings and Design: This was a retrospective observational study, conducted in a tertiary care hospital. Materials and Methods: 57 patients of snake bite-induced ARF, who required dialysis, were included. Clinical history taking, physical examination, and laboratory evaluation was done. All patients received standard treatment including anti-snake venom. Patients received peritoneal or hemodialysis depending on availability of resources. The Pearson Chi-Square test was used to analyze parametric variables. Results: Prevalence of ARF in snake bite was 20.48%. Common clinical manifestations were local cellulitis (100%), oliguria (84.2%), edema (33.3%), hematuria (29.8%), altered sensorium (26.3%), and bleeding manifestations (22.8%). Common laboratory findings were albuminuria (100%), anemia (54.3%); leucocytosis (61.4%); thrombocytopenia (42.1%); coagulopathy (36.8%); metabolic acidosis (31.5%). Conclusions: Snake bite-induced ARF has mortality of 15.5%. The factors associated with mortality were presence of coagulopathy and uremic encephalopathy. Though this study is not designed to compare hemodialysis and peritoneal dialysis, the better outcome in hemodialysis group suggests the need to compare the 2 modalities of renal replacement therapy in patients with snake bite-induced acute renal failure.

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“…We also observed that in our study, neurological toxicity was inversely related with the development of AKI. This could be due to low prevalence in our region of snakes which cause both neurotoxicity and kidney injury (e.g., sea snakes),[ 17 ] and also pure neurotoxic snakes do not cause renal injury.…”

Section: Discussionmentioning

confidence: 99%

Early demographic and clinical predictors of developing acute kidney injury in snake bite patients: A retrospective controlled study from an Indian tertiary care hospital in North Eastern Uttar Pradesh India

Singh¹,

Uraiya²,

Kumar³

et al. 2016

Indian Journal of Critical Care Medicine

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Aims:This study was conducted retrospectively to define early demographic and clinical predictors for acute kidney injury (AKI) among snake bite patients at the time of hospital admission.Materials and Methods:We analyzed 138 cases with a poisonous snake bite. Patients were classified into two groups according to the presence and absence of AKI. The data regarding clinical features and demographic profile of these patients were collected from the hospital records in a prestructured pro forma and statistically compared.Results:Of the 138 patients of venomous snake bite, 62 developed AKI (44.92%). Patients who developed AKI were older in age. Moreover, prolonged bite to anti-snake venom (ASV) time had a significant relationship in developing AKI (P < 0.05). Among the clinical features, there was an independent positive association of AKI with abdomen pain, tenderness and vomiting, cellulitis, bleeding tendencies, myalgia, and black or brown urine (P < 0.05). Neurological features were inversely associated with renal involvement.Conclusion:We found that marked abdominal pain, tenderness and vomiting, myalgia, black or brown urine, bite site cellulitis, bleeding tendencies, and prolonged (>2 h) bite to ASV time were significantly associated with the development of AKI in snake bite patients.

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Snake Venoms and Nephrotoxicity

Cited by 20 publications

References 27 publications

Snake Bite Induced Acute Renal Failure: A Study of Clinical Profile and Predictors of Poor Outcome

Snake Bite Induced Acute Renal Failure: A Study of Clinical Profile and Predictors of Poor Outcome

Snake bite-induced acute renal failure: A study of clinical profile and predictors of poor outcome

Early demographic and clinical predictors of developing acute kidney injury in snake bite patients: A retrospective controlled study from an Indian tertiary care hospital in North Eastern Uttar Pradesh India

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