Snake venom l-amino acid oxidases

Proteomics and Deep Sequencing Comparison of Seasonally Active Venom Glands in the Platypus Reveals Novel Venom Peptides and Distinct Expression Profiles

“…The gene is located on contig7479 in the genome assembly. Platypus amine oxidase is more similar to copper-containing amine oxidase than the flavin-containing L-amino acid oxidases found in snake venoms (27). Copper-containing amine oxidases degrade primary amines such as histidine to aldehydes, releasing ammonia and hydrogen peroxide.…”

“…Copper-containing amine oxidases degrade primary amines such as histidine to aldehydes, releasing ammonia and hydrogen peroxide. In viperid, crotalid, and elapid snakes, amide oxidases have high enzymatic activities that are believed to contribute to toxicity upon envenomation through the production of hydrogen peroxide (27). They have been shown to induce human platelet aggregation (28), assist in hemorrhage (27) and apoptosis (29), and cause edema and hemolysis (30).…”

Induction of apoptosis in yeast by L‐amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma

“…In addition, LAAO exhibits antibacterial and antiviral properties, inhibiting the growth of both Gram-positive and -negative prokaryotes as well as HIV (Skarnes, 1970;Zhang et al, 2003Zhang et al, , 2004. Although the generation of hydrogen peroxide is necessary for the induction of apoptosis, it was suspected that glycosylation of LAAO contributes to this process by interaction of the bis-sialylated N -glycan moiety with structures on the cell surface (Ande et al, 2006;Suhr andKim, 1996, Du andClemetson, 2002).…”

An Alternative Inactivant for Rift Valley Fever Virus using Cobra Venom-derived L-Amino Oxidase, which is Related to its Immune Potential

“…Snake venom LAAO is recognized as a multifunctional protein with promising biomedical applications. Several reviews on snake venom L-amino acid Oxidase have been published (Du and Clemetson 2002).…”