Snail defence responses to parasite infection: The Lymnaea stagnalis-Trichobilharzia szidati model

Skála, Vladimír; Walker, Anthony J.; Horák, Petr

doi:10.1016/j.dci.2019.103464

Cited by 17 publications

(5 citation statements)

References 106 publications

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“…[15] make the case for the pond snail L. stagnalis . This species has long been a model for neurobiology, but in more recent years, the genus has been used to study ecotoxicology [45], sexual selection [46], biomineralization [28], parasitology [47,48], and development [49]. However, while we do not doubt the relatively wide-ranging existing utility of the pond snail, development of further key resources would allow L. stagnalis to be applied powerfully to an even wider range of research questions.…”

Section: Making a Model Molluscmentioning

confidence: 99%

Mobilizing molluscan models and genomes in biology

Davison

Neiman

2021

Phil. Trans. R. Soc. B

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Molluscs are among the most ancient, diverse, and important of all animal taxa. Even so, no individual mollusc species has emerged as a broadly applied model system in biology. We here make the case that both perceptual and methodological barriers have played a role in the relative neglect of molluscs as research organisms. We then summarize the current application and potential of molluscs and their genomes to address important questions in animal biology, and the state of the field when it comes to the availability of resources such as genome assemblies, cell lines, and other key elements necessary to mobilising the development of molluscan model systems. We conclude by contending that a cohesive research community that works together to elevate multiple molluscan systems to ‘model’ status will create new opportunities in addressing basic and applied biological problems, including general features of animal evolution. This article is part of the Theo Murphy meeting issue ‘Molluscan genomics: broad insights and future directions for a neglected phylum’.

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Section: Making a Model Molluscmentioning

confidence: 99%

Mobilizing molluscan models and genomes in biology

Davison

Neiman

2021

Phil. Trans. R. Soc. B

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“…Lymnaea stagnalis is the most frequently reported intermediate host of avian schistosomes in Europe, with widespread geographical distribution across this continent [ 60 ]. Infection of this snail species with T. szidati has different effects in juveniles and adults: juvenile forms have their sexual development compromised, while adults increase their oviposition rate, seemingly due to disruption of snail neuroendocrine control [ 61 ]. Notably, a single infected L. stagnalis can generate CD cases, as it can release over 30,000 cercariae in one day [ 60 ].…”

Section: Intermediate and Definitive Hostsmentioning

confidence: 99%

Zoonotic Threats: The (Re)emergence of Cercarial Dermatitis, Its Dynamics, and Impact in Europe

Bispo,

Calado,

Maurício

et al. 2024

Pathogens

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Cercarial dermatitis (CD), or “Swimmer’s itch” as it is also known, is a waterborne illness caused by a blood fluke from the family Schistosomatidae. It occurs when cercariae of trematode species that do not have humans as their definitive host accidentally penetrate human skin (in an aquatic environment) and trigger allergic symptoms at the site of contact. It is an emerging zoonosis that occurs through water and is often overlooked during differential diagnosis. Some of the factors contributing to the emergence of diseases like CD are related to global warming, which brings about climate change, water eutrophication, the colonization of ponds by snails susceptible to the parasite, and sunlight exposure in the summer, associated with migratory bird routes. Therefore, with the increase in tourism, especially at fluvial beaches, it is relevant to analyze the current epidemiological scenario of CD in European countries and the potential regions at risk.

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“…Lymnaea stagnalis serves as the intermediate host for more than one hundred species of digenetic trematodes, including the avian schistosome Trichobilharzia szidati, a causative agent of cercarial dermatitis in humans (Fig. 3) [52]. A more serious disease is human schistosomiasis caused by several different parasites including Schistosoma mansoni for which the freshwater snail Biomphalaria (B.)…”

Section: Schistosomiasismentioning

confidence: 99%

The pond snail Lymnaea stagnalis

Kuroda

Abe

2020

EvoDevo

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The freshwater snail Lymnaea stagnalis has a long research history, but only relatively recently has it emerged as an attractive model organism to study molecular mechanisms in the areas of developmental biology and translational medicine such as learning/memory and neurodegenerative diseases. The species has the advantage of being a hermaphrodite and can both cross- and self-mate, which greatly facilitates genetic approaches. The establishment of body-handedness, or chiromorphogenesis, is a major topic of study, since chirality is evident in the shell coiling. Chirality is maternally inherited, and only recently a gene-editing approach identified the actin-related gene Lsdia1 as the key handedness determinant. This short article reviews the natural habitat, life cycle, major research questions and interests, and experimental approaches.

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Snail defence responses to parasite infection: The Lymnaea stagnalis-Trichobilharzia szidati model

Cited by 17 publications

References 106 publications

Mobilizing molluscan models and genomes in biology

Mobilizing molluscan models and genomes in biology

Zoonotic Threats: The (Re)emergence of Cercarial Dermatitis, Its Dynamics, and Impact in Europe

The pond snail Lymnaea stagnalis

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