SNAC for Enhanced Oral Bioavailability: An Updated Review

Kommineni, Nagavendra; Jyothi, Vaskuri G.S. Sainaga; Butreddy, Arun; Raju, S.; Shapira, Tovi; Khan, Wahid; Angsantikul, Pavimol; Domb, Abraham J.

doi:10.1007/s11095-022-03459-9

Cited by 11 publications

(2 citation statements)

References 130 publications

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“…58,59,74 The various approaches to associating the peptides include complexation, conjugation, crystallization, or self-assembly through chemical or physical additions. 89 Various types of particulate vehicles have been designed for encapsulation, protection and release of shortchain BAPs (hereafter simply referred to as 'BAPs'). In general, there are two main ways of loading the BAPs into these structures: (i) during the particle formation, sometimes referred to as in situ loading or the internal method and (ii) loading after particle formation, sometimes referred to as pro-loading or the external method.…”

Section: Reviewmentioning

confidence: 99%

Encapsulation of short-chain bioactive peptides (BAPs) for gastrointestinal delivery: a review

Atma,

Murray,

Sadeghpour

et al. 2024

Food Funct.

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Section: Reviewmentioning

confidence: 99%

Encapsulation of short-chain bioactive peptides (BAPs) for gastrointestinal delivery: a review

Atma,

Murray,

Sadeghpour

et al. 2024

Food Funct.

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“…To commemorate this new era of bioavailable peptide drugs, this review article summarizes the technological progress in improving the oral absorption of new drug modalities and discusses future prospects to improve absorption enhancement. Since numerous review articles about oral absorption enhancement technology have already been published [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ], this manuscript provides a brief explanation of these technologies in Section 2 . However, the main focus of this manuscript involves shedding light on new aspects of orally bioavailable middle-to-large molecules, mainly based on information in the recent (from 2020 to 2023) literature available in PubMed, in order to keep readers up to date with the latest technology.…”

Section: Introductionmentioning

confidence: 99%

Oral Absorption of Middle-to-Large Molecules and Its Improvement, with a Focus on New Modality Drugs

Asano,

Takakusa,

Nakai

2023

Pharmaceutics

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To meet unmet medical needs, middle-to-large molecules, including peptides and oligonucleotides, have emerged as new therapeutic modalities. Owing to their middle-to-large molecular sizes, middle-to-large molecules are not suitable for oral absorption, but there are high expectations around orally bioavailable macromolecular drugs, since oral administration is the most convenient dosing route. Therefore, extensive efforts have been made to create bioavailable middle-to-large molecules or develop absorption enhancement technology, from which some successes have recently been reported. For example, Rybelsus® tablets and Mycapssa® capsules, both of which contain absorption enhancers, were approved as oral medications for type 2 diabetes and acromegaly, respectively. The oral administration of Rybelsus and Mycapssa exposes their pharmacologically active peptides with molecular weights greater than 1000, namely, semaglutide and octreotide, respectively, into systemic circulation. Although these two medications represent major achievements in the development of orally absorbable peptide formulations, the oral bioavailability of peptides after taking Rybelsus and Mycapssa is still only around 1%. In this article, we review the approaches and recent advances of orally bioavailable middle-to-large molecules and discuss challenges for improving their oral absorption.

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Drug Delivery Systems

Azagury,

Kaeek,

Khoury

et al. 2023

Kirk-Othmer Encyclopedia of Chemical Technology

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Drug delivery systems (DDSs) and their administration routes play a critical role in the efficacy and safety of drugs. There are several physiological routes for drug delivery, including oral administration, injectables, inhalation, transdermal, intranasal, and transdermal delivery. This article focuses on these administration routes, describes their advantages and disadvantages, and elaborates on triggered and targeted DDS. Additionally, this article also describes drug release mechanisms from DDSs. DDSs are classified based on their physicochemical properties and administration routes. Pulsatile/stimuli systems allow controlled drug release at a specific time or location in response to an external stimulus. In addition, the controlled DDS employs several drug release mechanisms, such as diffusion, swelling, and erosion, to achieve the desired therapeutic effect. Representative applications of DDSs include the treatment of cancer, diabetes, and cardiovascular diseases. The COVID‐19 vaccine is a significant achievement in DDS, showcasing its potential to address global health crises. It utilizes lipid nanoparticles to encapsulate and protect mRNA, enabling targeted delivery to host cells. The mRNA instructs cells to produce the spike protein of the SARS‐CoV‐2 virus, triggering an immune response for COVID‐19 protection. In conclusion, DDSs and their administration routes are vital for safe and effective drug development, with recent advances such as pulsatile/stimuli systems showing promise for targeted delivery. The COVID‐19 vaccine development demonstrates the potential of DDS in tackling global health issues.

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SNAC for Enhanced Oral Bioavailability: An Updated Review

Cited by 11 publications

References 130 publications

Encapsulation of short-chain bioactive peptides (BAPs) for gastrointestinal delivery: a review

Encapsulation of short-chain bioactive peptides (BAPs) for gastrointestinal delivery: a review

Oral Absorption of Middle-to-Large Molecules and Its Improvement, with a Focus on New Modality Drugs

Drug Delivery Systems

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