Smugglers and Patriots: Boston Merchants and the Advent of the American Revolution

Tyler, John

doi:10.2307/365664

Cited by 6 publications

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“…The T.E.S.T. (The Toxicity Estimation Software Tool), an open source toxicity prediction tool developed by the US Environmental Protection Agency (EPA), was used to predict the oral rat median lethal dose (LD 50 ). The toxicity grade was analyzed based on the US EPA pesticide toxicity classification standards.…”

Section: Methodsmentioning

confidence: 99%

Virtual screening, synthesis, and bioactivity evaluation for the discovery of β‐N‐acetyl‐D‐hexosaminidase inhibitors

Dong

Zhao

et al. 2020

Pest Management Science

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BACKGROUNDMolting is an essential insect developmental process, in which a variety of enzymes are involved. The inhibition of these enzymes effect normal insect growth and development and may even cause death. OfHex1, one of the β‐N‐acetyl‐D‐hexosaminidases, is a key enzyme involved in the molting process of the Asian corn borer (Ostrinia furnacalis), and is deemed a potential insecticidal target.RESULTSBased on the crystal structure of OfHex1, virtual screening was carried out to obtain a novel class of OfHex1 inhibitors, of which, 28 compounds were subjected to bioactivity evaluation. The compound 3, N‐(3‐cyano‐4,5,6,7‐tetrahydrobenzo[b]thiophen‐2‐yl)benzamide, showed good inhibition against OfHex1 with a Ki value of 11.2 μM. Structure optimization and molecular docking were applied for the structure–activity relationship analysis. The results also showed that the cyano group of this compound was essential for the maintenance of its inhibitory activity against OfHex1. Additionally, the interaction between this compound and Trp490, Glu328, Tyr475 and Trp524 were important for inhibitory activity.CONCLUSIONThe advantages of the derivatives of 2‐amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐3‐carbonitrile, which have simple chemical structures and are easily synthesized, suggests them to be developed further as potential OfHex1 inhibitors for pest control. © 2020 Society of Chemical Industry

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Section: Methodsmentioning

confidence: 99%

Virtual screening, synthesis, and bioactivity evaluation for the discovery of β‐N‐acetyl‐D‐hexosaminidase inhibitors

Dong

Zhao

et al. 2020

Pest Management Science

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“A Moral Distemper in the British Government”

2016

The Loyalist Problem in Revolutionary New England

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Did Dutch Smugglers Provoke the Boston Tea Party?

Carp¹

2012

eam

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The people of Boston dramatically rejected the Tea Act of 1773. This article imbricates Boston within the intercolonial, trans-Atlantic, and global networks that sustained its commerce. Like New Yorkers and Philadelphians, Bostonians smuggled tea and other commodities (sometimes called the “Dutch trade”) and joined the colonial nonimportation agreements. Unlike their counterparts, however, some Boston merchants had also violated the agreements by continuing to import British tea. This article argues that Atlantic smugglers trading with the Netherlands and other European nations helped create the conditions for the Boston Tea Part and helped provoke it. The Boston Tea Party was a dramatic rejection of the Tea Act of 1773. Yet of the four seaports where the East India Company sent its tea, Boston should have been the least likely to host the destruction of the tea shipments. To understand why, it is helpful to imbricate Boston within the intercolonial and trans-Atlantic (even global) networks that sustained it. Had it not been for pressure from smugglers in the “Dutch trade” operating in New York City and Philadelphia, Boston might have been disinclined to participate in such a dramatic protest. Atlantic smugglers trading with the Netherlands and other European nations helped create the conditions for the Boston Tea Party and helped provoke it.

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Smugglers and Patriots: Boston Merchants and the Advent of the American Revolution

Cited by 6 publications

References 0 publications

Virtual screening, synthesis, and bioactivity evaluation for the discovery of β‐N‐acetyl‐D‐hexosaminidase inhibitors

Virtual screening, synthesis, and bioactivity evaluation for the discovery of β‐N‐acetyl‐D‐hexosaminidase inhibitors

“A Moral Distemper in the British Government”

Did Dutch Smugglers Provoke the Boston Tea Party?

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