Smoothened agonist augments proliferation and survival of neural cells

Bragina, Olga; Sergejeva, Svetlana; Serg, Martin; Zarkovsky, Tamara; Maloverjan, Alla; Kogerman, Priit; Zarkovsky, A.M.

doi:10.1016/j.neulet.2010.06.068

Cited by 35 publications

(24 citation statements)

References 25 publications

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“…It is possible that enhanced Shh ligand from the VDB may be transported via the septo-hippocampal pathway resulting in increased Shh signaling within the hippocampus (61), which is supported by the evidence of enhanced Ptc expression in the DG. In this context, it is noteworthy that T 3 administration is capable of increasing the postmitotic survival and neuronal differentiation of hippocampal progenitors (62), an effect that overlaps with the enhanced survival observed after treatment with Smo agonists (63). …”

Section: Discussionmentioning

confidence: 99%

Thyroid Hormone Regulates the Expression of the Sonic Hedgehog Signaling Pathway in the Embryonic and Adult Mammalian Brain

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Thyroid Hormone Regulates the Expression of the Sonic Hedgehog Signaling Pathway in the Embryonic and Adult Mammalian Brain

et al. 2011

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“…Studies have specifically implicated Hh in the adult maintenance of hematopoietic stem cells40, epithelial stem cells in the gastrointestinal tract41, neuronal stem cells in the subventricular zone (SVZ) and the hippocampal dentate gyrus4243, hair follicle stem cells44, mammary stem cells45 and mesenchymal stem cells46. Besides its role in neurogenesis, Hh has also shown neurotrophic properties, in particular regarding dopaminergic neuron survival474849. Administration of Sonic Hedgehog reduced behavioral deficits in animal models of PD5051.…”

Section: Discussionmentioning

confidence: 99%

Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease

Valente

Shin

Sarkar

et al. 2012

Sci Rep

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An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's disease is discussed in the context of a Parkinson's disease stem-cell ageing theory.

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“…Further, our group has shown the neuroprotective effects of Shh pathway augmentation via a small molecule, smoothened agonist (SAG), against human immunodeficiency virus (HIV)-associated neuropathology in humanized mice (Singh et al 2016). Not only that, but SAG was also shown to prevent neuropathology in a rat model of spinal cord injury as well as a mouse model for Down’s syndrome(Bambakidis et al 2010; Bragina et al 2010), indicating that this approach might lead to timely identification of a neuroprotective drug in order to dampen ZIKV-associated neurological complications.…”

Section: Pharmacological Interventions Against Zikv Infectionmentioning

confidence: 99%

Preventive and therapeutic challenges in combating Zika virus infection: are we getting any closer?

et al. 2017

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The neuroteratogenic nature of Zika Virus (ZIKV) infection has converted what would have been a tropical disease into a global threat. Zika is transmitted vertically via infected placental cells especially in the first and second trimesters. In the developing central nervous system (CNS), ZIKV can infect and induce apoptosis of neural progenitor cells subsequently causing microcephaly as well as other neuronal complications in infants. Its ability to infect multiple cell types (placental, dermal, and neural) and increased environmental stability as compared to other flaviviruses (FVs) has broadened the transmission routes for ZIKV infection from vector-mediated to transmitted via body fluids. To further complicate the matters, it is genetically similar (about 40%) with the four serotypes of dengue virus (DENV), so much so that it can almost be called a fifth DENV serotype. This homology poses the risk of causing cross-reactive immune responses and subsequent antibody-dependent enhancement (ADE) of infection in case of secondary infections or for immunized individuals. All of these factors complicate the development of a single preventive vaccine candidate or a pharmacological intervention that will completely eliminate or cure ZIKV infection. We discuss all of these factors in detail in this review and conclude that a combinatorial approach including immunization and treatment might prove to be the winning strategy.

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Smoothened agonist augments proliferation and survival of neural cells

Cited by 35 publications

References 25 publications

Thyroid Hormone Regulates the Expression of the Sonic Hedgehog Signaling Pathway in the Embryonic and Adult Mammalian Brain

Thyroid Hormone Regulates the Expression of the Sonic Hedgehog Signaling Pathway in the Embryonic and Adult Mammalian Brain

Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease

Preventive and therapeutic challenges in combating Zika virus infection: are we getting any closer?

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