Abstract:The α1‐adrenoreceptor (α1‐AR) agonist, phenylephrine (PE) induces Ca2+ transients in endothelial cells (EC) of arterioles, possibly due to movement of Ca2+ or IP3 from smooth muscle (SMC) into EC via gap junctions. However, the presence of α1‐AR on EC has not been excluded, and their identity in arterioles only has been inferred from pharmacology. Therefore, we determined which α1‐AR subtypes are expressed by SMC and EC, and which subtype mediates PE‐induced EC Ca2+ transients. Cell specific expression was ass… Show more
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