Smooth muscle expression of RNA editing enzymeADAR1controls vascular integrity and progression of atherosclerosis
Chad S. Weldy,
Qin Li,
João P. Monteiro
et al.
Abstract:Mapping the genomic architecture of complex disease has been predicated on the understanding that genetic variants influence disease risk through modifying gene expression. However, recent discoveries have revealed that a significant burden of disease heritability in common autoinflammatory disorders and coronary artery disease is mediated through genetic variation modifying post-transcriptional modification of RNA through adenosine-to-inosine (A-to-I) RNA editing. This common RNA modification is catalyzed by … Show more
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