“…Transcripts and functional expression of TRPA1 have been found in NG and DRG neurons innervating mouse and rat stomach and colon (128,417,822), mouse jejunum and ileum (128,144,162,501,654), and guinea pig esophagus (482,931,932). TRPA1 has been also detected in intestinal tissue samples of mouse, guinea pig, and dog (71,214,654), as well as in rat and human colonic epithelial cells (362,363) and enterochromaffin cells (EC), mouse duodenal and colonic enterocytes (255), and mouse and human mucosa (81,214,604,675). Moreover, TRPA1 is expressed in mouse enteroendocrine cells (EEC), commonly in the duodenum and jejunum, and in human enteric glial cells cultures, where TRPA1 transcripts are upregulated by E. coli LPS incubation (159,476).…”