Smooth muscle cell proliferation and localization of macrophages and T cells in the occlusive intracranial major arteries in moyamoya disease.

Masuda, Junichi; Ogata, Jun; Yutani, Chikao

doi:10.1161/01.str.24.12.1960

Cited by 158 publications

(104 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Firstly, the inflammatory process hypothesis has been proposed by Masuda et al 41) However, as is well known, the characteristics of the stenotic change seen in moyamoya disease are quite different from those of the atherosclerotic process seen in adults. There is no lipid pool or inflammatory cell or macrophage invasion to the sub-intimal layer as typically seen in atherosclerosis.…”

Section: Pathological Study and Abnormal Thrombogenesismentioning

confidence: 99%

Review of Past Research and Current Concepts on the Etiology of Moyamoya Disease

Houkin

Ito

Sugiyama

et al. 2012

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

Research on moyamoya disease has progressed remarkably in the past several decades. Indeed, many new facts concerning the epidemiology of the disease have been revealed and surgical treatments have been drastically improved. However, despite extensive research, the mechanism of moyamoya disease is still unknown. Consequently, the cardinal treatment of this disease has not yet been developed. For further clarification of its etiology, innovative studies are therefore indispensable. The aim of this paper is to review research on the pathogenesis of moyamoya disease to identify milestones in the direction of its true solution. Many hypotheses of the pathogenesis of moyamoya disease have been proposed in the past half century, including infection (viral and bacterial), autoimmune disorders, proteins abnormality, and gene abnormality. Some of these are now considered to be historical achievements. Others, however, can be still subjected to contemporary research. Currently, several genetic abnormalities are considered to offer the most probable hypothesis. In addition, interesting papers have been presented on the role of the endothelial progenitor cell on the pathogenesis of moyamoya disease. Intuitively, however, it appears that a single theory cannot always explain the pathogenesis of this disease adequately. In other words, the complex mechanism of several factors may comprehensively explain the formation of moyamoya disease. The``double hit hypothesis'' is probably the best explanation for the complicated pathology and epidemiology of this disease.

show abstract

Section: Pathological Study and Abnormal Thrombogenesismentioning

confidence: 99%

Review of Past Research and Current Concepts on the Etiology of Moyamoya Disease

Houkin

Ito

Sugiyama

et al. 2012

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

show abstract

“…The aetiology, natural history, pathogenesis and ideal treatment of Moyamoya disease have been poorly defined. [18][19][20] Congenital and acquired forms have been described, sometimes in association with disorders of haemosthasy, sickle cell disease, Down's syndrome and infection. Hypertension is uncommonly reported.…”

Section: Discussionmentioning

confidence: 99%

Moyamoya disease associated with renovascular disease in a young African-Brazilian patient

Fuchs

et al. 2001

J Hum Hypertens

View full text Add to dashboard Cite

Moyamoya is a rare disease characterized by fibrous dysplasia of the internal carotid and proximal cerebral arteries, which has been described mainly in young Japanese. We present a case of Moyamoya disease with renal artery involvement in a young male patient with an African origin. A 15-year-old boy was referred to our hospital due to uncontrolled blood pressure, headache, somnolence, cognitive deficit and multiple lacunar infarcts in the computed tomography. Cerebral arteriography showed the absence of the normal vascular anatomy at the level of the circle of Willis. The intracraneal vessels presented severe stenosis or were occluded and replaced by an extensive network of ectasic collateral vessels. Abdominal ultrasound examination identified asymmetric kidneys, and renal arteriog-

show abstract

“…If present, however, they most often comprise the subintimal SMC, which show a positive immune reaction against a-SMA. The cells proliferation may appear in the perforating vessels of patients with systemic hypertension, atherosclerosis and some other vascular diseases [1,15]. The observed negative reaction against DES [15] was probably due to the fact that these muscle cells belong to the secretory and not to the contractile type.…”

Section: Tunica Intimamentioning

confidence: 98%

Structure and immunohistochemistry of the human lenticulostriate arteries

Marinković

Todorovic²,

Drndarević³

et al. 2013

Folia Morphol

View full text Add to dashboard Cite

show abstract

Smooth muscle cell proliferation and localization of macrophages and T cells in the occlusive intracranial major arteries in moyamoya disease.

Cited by 158 publications

References 21 publications

Review of Past Research and Current Concepts on the Etiology of Moyamoya Disease

Review of Past Research and Current Concepts on the Etiology of Moyamoya Disease

Moyamoya disease associated with renovascular disease in a young African-Brazilian patient

Structure and immunohistochemistry of the human lenticulostriate arteries

Contact Info

Product

Resources

About