Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation

Xie, Zhongwen; Su, Wen; Liu, Shu; Zhao, Guogang; Esser, Karyn A.; Schroder, Elizabeth A.; Lefta, Mellani; Stauss, Harald M.; Guo, Zhenheng; Gong, Ming

doi:10.1172/jci76881

Cited by 145 publications

(157 citation statements)

References 53 publications

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“…Blood pressure [28–30], vascular remodeling [8, 10, 31–33], atherosclerosis [13], cardiac injury [34–37], and coagulation [38] are all influenced by circadian clock genes. Thus, this molecular regulator of 24-h rhythmicity controls not only daily and acute pathophysiology, such as blood pressure and thrombosis, but also chronic responses.…”

Section: Discussionmentioning

confidence: 99%

Differential Regulation of BMAL1, CLOCK, and Endothelial Signaling in the Aortic Arch and Ligated Common Carotid Artery

Shang

Pati²,

Anea³

et al. 2016

J Vasc Res

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The circadian clock is rhythmically expressed in blood vessels, but the interaction between the circadian clock and disturbed blood flow remains unclear. We examined the relationships between BMAL1 and CLOCK and 2 regulators of endothelial function, AKT1 and endothelial nitric oxide synthase (eNOS), in vascular regions of altered blood flow. We found that the aortic arch from WT mice exhibited reduced sensitivity to acetylcholine (Ach)-mediated relaxation relative to the thoracic aorta. In Clock-mutant (mut) mice the aorta exhibited a reduced sensitivity to Ach. In WT mice, the phosphorylated forms of eNOS and AKT were decreased in the aortic arch, while BMAL1 and CLOCK expression followed a similar pattern of reduction in the arch. In conditions of surgically induced flow reduction, phosphorylated-eNOS (serine 1177) increased, as did p-AKT in the ipsilateral left common carotid artery (LC) of WT mice. Similarly, BMAL1 and CLOCK exhibited increased expression after 5 days in the remodeled LC. eNOS expression was increased at 8 p.m. versus 8 a.m. in WT mice, and this pattern was abolished in mut and Bmal1-KO mice. These data suggest that the circadian clock may be a biomechanical and temporal sensor that acts to coordinate timing, flow dynamics, and endothelial function.

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Section: Discussionmentioning

confidence: 99%

Differential Regulation of BMAL1, CLOCK, and Endothelial Signaling in the Aortic Arch and Ligated Common Carotid Artery

Shang

Pati²,

Anea³

et al. 2016

J Vasc Res

View full text Add to dashboard Cite

show abstract

“…Similarly, Per1 mutants displayed significantly shorter circadian period and were unable to maintain the precision and stability [102]. Interestingly, deletion of Bmal1 from the vascular smooth muscle cells impaired vessel contractility and consequently, decreased mean arterial pressure through peripheral inputs [103]. In addition, deletion of Bmal1 also induced the attenuated rhythm of the body temperature [101].…”

Section: Clock Gene Differencementioning

confidence: 99%

A New Perspective for Parkinson’s Disease: Circadian Rhythm

Wang

et al. 2016

Neurosci. Bull.

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Circadian rhythm is manifested by the behavioral and physiological changes from day to night, which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei (SCN) in the anterior hypothalamus, while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles, rest and activity cycles. Parkinson's disease (PD) exhibits diurnal fluctuations. Circadian dysfunction has been observed in PD patients and animal models, which may result in negative consequences to the homeostasis and even exacerbate the disease progression. Therefore, circadian therapies, including light stimulation, physical activity, dietary and social schedules, may be helpful for PD patients. However, the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD, focusing on the clinical symptom variations, molecular changes, as well as the available treatment options.

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“…Human biological and behavioral changes during a day are controlled by suprachiasmatic nucleus located on the front of hypothalamus; suprachiasmatic nucleus is also called central pacemaker (15), which is controlling cardiovascular function, hormones, blood volume, blood pressure, etc., and there is a close relationship between the changes in sleep-wake patterns and nucleus performance (6). The lowest blood pressure is usually at night, which is going to rise before wakening; it can increase cardiac arrest among the subjects with cardiac disease (15).…”

Section: Introductionmentioning

confidence: 99%

“…The lowest blood pressure is usually at night, which is going to rise before wakening; it can increase cardiac arrest among the subjects with cardiac disease (15). Therefore, hormonal, neurological, and behavioral changes in a 24-hour rhythm are among the effective factors in cardiovascular events (4).…”

Section: Introductionmentioning

confidence: 99%