Smooth Muscle Antibody in Malignant Disease

Whitehouse, J. M. A.; Holborow, E. J.

doi:10.1136/bmj.4.5786.511

Cited by 124 publications

(43 citation statements)

References 6 publications

(6 reference statements)

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“…These percentages correspond to those found in various control groups, about 20% of whom may be expected to have some detectable smooth muscle antibody (18). No other autoantibodies were found.…”

Section: Resultsmentioning

confidence: 99%

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The association of antinuclear antibodies with the chronic iridocyclitis of juvenile rheumatoid arthritis (Still's disease)

Schaller

Johnson

Holborow

et al. 1974

Arthritis & Rheumatism

134

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Positive tests for antinuclear antibodies (ANA) were found in 51 of 58 (88%) patients with chronic iridocyclitis and juvenile rheumatoid arthritis (Still's disease). Antinuclear antibodies were predominantly of the IgG class of immunoglobulins and were generally present in titers of 1 5 0 (six ANA units) or more. They were unassociated with disease activity, severity or duration, age of patient at onset or testing, or sex. Neither other autoantibodies nor antibodies reactive with DNA or RNA were associated. In 8 patients tested early in disease, ANA were found prior to the onset of iridocyclitis. The presence of ANA should prove useful in identifying patients with JRA at risk for chronic iridocyclitis. In contrast, negative tests for ANA in patients with childhood-onset arthritis and iridocyclitis were found to be associated with acute iridocyclitis and subsequent ankylosing spondylitis.Iridocyclitis, inflammation of the iris and ciliary body, affects about 10% of children with juvenile rheumatoid arthritis (JRA,

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Section: Resultsmentioning

confidence: 99%

“…Antinuclear antibodies are also known to be associated with certain infectious processes (25), malignancies (18), and with the normal aging process (26).…”

Section: Discussionmentioning

confidence: 99%

The association of antinuclear antibodies with the chronic iridocyclitis of juvenile rheumatoid arthritis (Still's disease)

Schaller

Johnson

Holborow

et al. 1974

Arthritis & Rheumatism

134

View full text Add to dashboard Cite

show abstract

“…The fact that autoimmunization with irradiated tumour cells abolished the serum inhibitory activity in the case of malignant melanoma studied, would perhaps indicate that the serum inhibitor (? circulating tumour cell antigen) was cleared from the circulation by antibody (Ikonopisov et al, 1970) (Whitehouse and Holborow, 1971) and it is conceivable that cell-mediated reactions to organ and tissue specific antigens may masquerade as tumourspecific reactions. A possible explanation for the cross reactivity is that malignant transformation is associated with exposure of an antigen on the cell surface, which is normally present but shielded by some material and therefore not " expressed " oIn the normal tissue.…”

Section: Discussionmentioning

confidence: 99%

Serum Mediated Inhibition of the Immunological Reactions of the Patient to his Own Tumour: A Possible Role for Circulating Antigen

Currie¹,

Basham²

1972

Br J Cancer

256

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Summary.-In a microcytotoxicity assay the lymphocytes from cancer patients were tested on autologous and allogeneic tumour cells in vitro. In patients with a variety of tumours, extensive washing of the lymphocytes from those cases with advanced disease was found to greatly enhance their specific cytotoxic effects. This specificity was restricted to autologous tumour cells and allogeneic cells of similar histological origin. This cross-reacting cytotoxicity was not, however, universal, especially in cases of malignant melanoma. The cytotoxicity evoked by washing was abolished by the addition of the patient's serum. This serum effect showed a similar specificity to that found for lymphocyte cytolysis. The effect of washing, and the specific inhibitory effect of serum, was not detectable in early cases of primary malignant melanoma. The serum component responsible for inhibiting lymphocyte cytotoxicity had no detectable affinity for the target cells and appears to act on the lymphocyte surface, implying that tumour antigen may well be implicated.

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“…An increased prevalence of smooth muscle and antinuclear antibodies exists in patients with malignant disease (35). In one study of 100 patients with breast cancer and 75 age-matched controls, antinuclear antibodies and smooth muscle antibodies were more frequent in cancer patients than controls (P < 0.005; ref.…”

Section: Discussionmentioning

confidence: 99%

Concerted Potent Humoral Immune Responses to Autoantigens Are Associated with Tumor Destruction and Favorable Clinical Outcomes without Autoimmunity

Sittler

Zhou

Park

et al. 2008

Clinical Cancer Research

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Purpose: The therapeutic importance of immune responses against single versus multiple antigens is poorly understood. There also remains insufficient understanding whether responses to one subset of antigens are more significant than another. Autoantibodies are frequent in cancer patients. They can pose no biological significance or lead to debilitating paraneoplastic syndromes. Autoreactivity has been associated with clinical benefits, but the magnitude necessary for meaningful results is unknown. Autologous tumor cells engineered to secrete granulocyte macrophage colony-stimulating factor generate immune infiltrates in preexisting metastases with associated tumor destruction. We sought to identify targets of responses from this vaccination strategy. Experimental Design: Postvaccination sera used in screening a cDNA expression library prepared from a densely infiltrated metastasis of a long-term surviving melanoma patient identified several autoantigens. Additional autoantigens were identified through similar screenings in non^small cell lung cancer and murine models, and proteins implicated in cancer propagation. ELISAs for several targets were established using recombinant proteins, whereas others were evaluated by petit serologies. Results: Eleven gene products were identified through serologic screening from two patients showing highly favorable clinical outcomes. A subset of antigens revealed significant changes in antibody titers compared with weak responses to other proteins. Time course analyses showed coordinated enhanced titers against several targets as a function of vaccination in responding patients. Conclusions: This study shows the range of biologically significant antigens resulting from a whole-cell vaccine. Targets include autoantigens that are components of cell cycle regulation. Potent antibody responses against multiple autoantigens are associated with effective tumor destruction without clinical autoimmunity.

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Smooth Muscle Antibody in Malignant Disease

Cited by 124 publications

References 6 publications

The association of antinuclear antibodies with the chronic iridocyclitis of juvenile rheumatoid arthritis (Still's disease)

The association of antinuclear antibodies with the chronic iridocyclitis of juvenile rheumatoid arthritis (Still's disease)

Serum Mediated Inhibition of the Immunological Reactions of the Patient to his Own Tumour: A Possible Role for Circulating Antigen

Concerted Potent Humoral Immune Responses to Autoantigens Are Associated with Tumor Destruction and Favorable Clinical Outcomes without Autoimmunity

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