Abstract:The underlying mechanism of pathogenesis of hypertension has been intensely investigated but remains largely unknown. Hypertension is generally thought to be associated with the disorder of Ca 2 + regulation in vascular smooth muscle such as the increase of Ca 2 + influx, the decrease of Ca 2 + efflux , or the change of sensitivity of contractile protein to Ca2+, etc. An increase of Ca2+ influx may be due to an increased Ca 2 + channel activity but the causal relationships of Ca2+ channel activity and hyperten… Show more
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