Smooth endoplasmic reticulum cluster presence does not affect embryo ploidy

Mizobe, Yamato; Kuwatsuru, Yukari; Kuroki, Y.; Fukumoto, Yumiko; Tokudome, Mari; Moewaki, Harue; Tabira, Marina; Iwakawa, Tokiko; Takeuchi, Kazuhiro

doi:10.1007/s00404-023-06969-y

Cited by 3 publications

(1 citation statement)

References 22 publications

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“… 19 Previous reports also did not observe differences in the rate of euploid embryos between these two groups. 31 , 37 The systematic mini-review by Shaw-Jackson et al reported that out of 183 newborns born from SERc(+) cycles, 171 were healthy, 8 were born with congenital anomalies, 3 neonates died, 1 was stillborn, and additionally, there were 4 cases of terminated pregnancies. 38 …”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Smooth Endoplasmic Reticulum Clusters in Metaphase II Oocytes and Embryological and Birth Outcomes in Infertile Couples

Nguyen Thanh,

Nguyen,

Dinh Le

et al. 2024

IJGM

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Background To assess the relationship between oocytes with smooth endoplasmic reticulum cluster (SERc) and embryological and birth outcomes in infertile couples. Methods This was a descriptive study that included 231 infertile patients undergoing in vitro fertilization (IVF) with a total of 2447 mature oocytes (MII), of which 279 oocytes with SERc(+) from 100 patients, the remaining 2168 oocytes with SERc(-). Oocytes were evaluated for the presence or absence of the SERc simultaneously with intracytoplasmic sperm injection at 200x magnification using inverted microscopy – Observe D1. Results The mean age of patients was 32.05 ± 5.56 years. One hundred patients had at least one SERc(+) oocyte (with 279 SERc(+) and 956 SERc(-) oocytes). One hundred and thirty-one patients had 1212 SERc(-) oocytes. Fertilization outcomes and the rates of good-quality embryos on day 2 and day 5 did not differ between the SERc(+) and the SERc(-) groups. In the first frozen embryo transfer cycles, the clinical pregnancy rate in the group of patients with SERc(+) was not different with the SERc(-) group (61.1% vs 48.78%, p = 0.074, respectively). The live birth rate in the SERc(+) group was statistically significantly higher than the SERc(-) group (57.7% vs 43.9%, p = 0.045, respectively). Conclusion The fertilization rate, the quality of embryos on days 2 and 5 from oocytes with SERc(+) are similar to those with SERc(-). The live birth rate in the patients with SERc(+) group is statistically significantly higher than the SERc(-) group. There is no difference in clinical pregnancy rate between patients with and without SERc. Therefore, the exclusion of oocytes with SERc should not be recommended.

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Section: Discussionmentioning

confidence: 99%

The Relationship Between Smooth Endoplasmic Reticulum Clusters in Metaphase II Oocytes and Embryological and Birth Outcomes in Infertile Couples

Nguyen Thanh,

Nguyen,

Dinh Le

et al. 2024

IJGM

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Advances in fluorescent probes for targeting organelles: Design strategies, applications and perspectives

Zhu,

Li,

Sun

et al. 2024

Coordination Chemistry Reviews

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Smooth endoplasmic reticulum aggregates in oocytes associated with increased risk of neonatal birth defects: A meta‐analysis

Long,

Wang,

Yang

et al. 2024

Acta Obstet Gynecol Scand

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IntroductionPrevious studies have indicated the association between smooth endoplasmic reticulum aggregates (SERa+) and poorer medically assisted reproduction outcomes. However, the link between SERa+ and neonatal outcomes remains controversial and open for debate. A comprehensive meta‐analysis on the relation between SERa+ and the risk of birth defects is needed.Material and MethodsThe literature search was conducted using the following databases: PubMed, Embase, Cochrane Libraries, Web of Science, and Chinese databases including China National Knowledge Infrastructure (CNKI) and Wan Fang from inception until July 2023. Risk ratio (RR) and 95% confidence interval (CI) were calculated by a fixed‐effected model, while heterogeneity was assessed by forest plots and I2 statistic. Funnel plot was produced to assess publication bias. This meta‐analysis has been registered on PROSPERO (CRD42022313387).ResultsThe search resulted in 122 studies, 14 of which met the inclusion criteria. The analysis of birth defects revealed a higher risk (RR = 2.17, 95%CI 1.24 to 3.81, p = 0.007) in children derived from SERa+ cycle compared to SERa‐ cycles (711 vs. 4633). Meanwhile, in a subgroup analysis, the risk of birth defects was significantly increased in the SERa+ oocytes group as compared with the sibling SERa‐ oocytes group (RR = 3.53, 95%CI 1.21 to 10.24, p = 0.02).ConclusionsTo conclude, our analysis indicated that SERa+ cycles/oocytes may have a potential risk of increased additional major birth defects comparing with SERa‐ cycles/oocytes. This conclusion may provide evidence‐based support for clinicians in IVF clinical guidance and embryologists in prudent embryo selection strategy.

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Smooth endoplasmic reticulum cluster presence does not affect embryo ploidy

Cited by 3 publications

References 22 publications

The Relationship Between Smooth Endoplasmic Reticulum Clusters in Metaphase II Oocytes and Embryological and Birth Outcomes in Infertile Couples

The Relationship Between Smooth Endoplasmic Reticulum Clusters in Metaphase II Oocytes and Embryological and Birth Outcomes in Infertile Couples

Advances in fluorescent probes for targeting organelles: Design strategies, applications and perspectives

Smooth endoplasmic reticulum aggregates in oocytes associated with increased risk of neonatal birth defects: A meta‐analysis

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