Smoking Status and Gastric Cancer Risk: An Updated Meta-Analysis of Case-Control Studies Published in the past Ten Years

Torre, Giuseppe La; Chiaradia, Giacomina; Gianfagna, Francesco; Lauretis, Angelo De; Boccia, Stefania; Mannocci, Alice; Ricciardi, Walter

doi:10.1177/030089160909500103

Cited by 82 publications

(67 citation statements)

References 64 publications

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“…Our findings indicated that tobacco smoking was associated with 1.62-fold higher risk of GC (95%CI: 1.50-1.74) compared with nonsmokers in Chinese population. This is consistent with a previous review based on international cohort studies, which reported a pooled RR of 1.53 (95%CI: 1.42-1.65) and a meta-analysis of international case-control studies with a pooled OR of 1.48 (95%CI: 1.28-1.71) (Ladeiras-Lopes R et al, 2008;La Torre et al, 2009).…”

Section: Discussionsupporting

confidence: 92%

Association of Risk of Gastric Cancer and Consumption of Tobacco, Alcohol and Tea in the Chinese Population

Tong

Liang²,

Chai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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This study aimed at summarizing epidemiological research findings on associations between tobacco, alcohol and tea consumption and risk of gastric cancer (GC) in the Chinese population. The review searched PubMed, Embase, China National Knowledge Infrastructure (CNKI) and China Biology Medicine (CBM) databases and reference lists of review papers for all studies published in English or Chinese languages. Information extracted, via two independent researchers, from retrieved articles included first author, year of publication, study design, sample size, source of controls and adjusted odds ratio (OR) or relative risk (RR) with the corresponding 95% confidence intervals (CIs) for each category. Statistical analyses used software STATA version 12.0. The systematic search found 89 articles containing 25,821 GC cases and 135,298 non-cases. The overall random effects in terms of pooled OR and 95%CI for tobacco, alcohol and tea consumption were 1.62 (95%CI: 1.50-1.74), 1.57 (95%CI: 1.41-1.76) and 0.67 (95%CI: 0.59-0.76) respectively; while the heterogeneity among included studies ranged from 80.1% to 87.5%. The majority of subgroup analyses revealed consistent results with the overall analyses. All three behavioral factors showed statistically significant dose-dependent effects on GC (P<0.05). The study revealed that tobacco smoking and alcohol drinking were associated with over 1/2 added risk of GC, while tea drinking conferred about 1/3 lower risk of GC in the Chinese population. However, these results should be interpreted with caution given the fact that most of the included studies were based on a retrospective design and heterogeneity among studies was relatively high.

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Section: Discussionsupporting

confidence: 92%

Association of Risk of Gastric Cancer and Consumption of Tobacco, Alcohol and Tea in the Chinese Population

Tong

Liang²,

Chai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Almost certainly, these include a more varied diet and better food conservation, including refrigeration, as well as control of infection by Helicobacter pylori (H pylori) (22,23) , decreasing of risk factors exposure, such as consumption of salt and salty foods, which can lead to damage of the protective layer of the mucosa of stomach (11,22) and smoking (18) .…”

Section: Discussionmentioning

confidence: 99%

Trend of mortality rates for gastric cancer in Brazil and regions in the period of 30 years (1980-2009)

Guimarães

Muzi

2012

Arq. Gastroenterol.

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CONTEXT: The most recent global estimate revealed the presence of about one million new cases of stomach cancer for the year 2008, setting itself as the fourth most common cause of cancer. OBJECTIVE: The present study aims to assess the trend of mortality from stomach cancer in Brazil according to regions between 1980 and 2009. METHODS: Data on deaths from stomach cancer were obtained from the Mortality Information System, and the demographic data, from the Brazilian Institute of Geography and Statistics. The rates of mortality were standardized by age according to world population. The trend curves were calculated for Brazilian regions by sex. The technique used was polynomial regression and joinpoint. RESULTS: The tendency for males and females is similar in all regions, although the magnitude is higher among men in all places. Regions Midwest, South, Southeast tended to decline, while the Northern region showed no significant trend, and the Northeast tended to increase. CONCLUSION: It is therefore a need to evaluate public health policies for gastric cancer aimed at the demographic transition (change of urbanization and lifestyle) that is occurring throughout the country.

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“…Two meta-analyses of published literature considering, respectively, 32 cohort (Ladeiras-Lopes et al, 2008) and 46 case-control studies (La Torre et al, 2009) showed a significant increase in the risk of gastric cancer among smokers, although quantification of the dose-response relations remains imprecise.…”

Section: Introductionmentioning

confidence: 99%

Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project

Praud

Rota

Pelucchi

et al. 2018

European Journal of Cancer Prevention

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157

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Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the 'Stomach cancer Pooling (StoP) Project' , including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09-1.32) for ever, 1.12 (95% CI: 0.99-1.27) for former, and 1.25 (95% CI: 1.11-1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10-1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14-1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend < 0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori + controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.

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Smoking Status and Gastric Cancer Risk: An Updated Meta-Analysis of Case-Control Studies Published in the past Ten Years

Cited by 82 publications

References 64 publications

Association of Risk of Gastric Cancer and Consumption of Tobacco, Alcohol and Tea in the Chinese Population

Association of Risk of Gastric Cancer and Consumption of Tobacco, Alcohol and Tea in the Chinese Population

Trend of mortality rates for gastric cancer in Brazil and regions in the period of 30 years (1980-2009)

Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project

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