Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction

Njølstad, Inger; Arnesen, Egil; Lund‐Larsen, Per G.

doi:10.1161/01.cir.93.3.450

Cited by 340 publications

(229 citation statements)

References 43 publications

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“…The identification of this 19q13 COPD locus, in conjunction with 15q25, highlights the critical contribution of variants affecting the major behavioral risk factor for COPD, cigarette smoking. This is in contrast to coronary artery disease, where despite the fact that cigarette smoking is a major risk factor (47), none of the identified genome-wide association loci to date has identified variants known to affect smoking, and a minority of the identified loci have been associated with traditional risk factors (48). Ongoing cigarette smoking causes accelerated lung function decline; conversely, smoking cessation attenuates this decline, improves respiratory symptoms and reduces overall mortality (49)(50)(51)(52).…”

Section: Discussionmentioning

confidence: 99%

A Genome-Wide Association Study In COPD Identifies A Susceptibility Locus On Chromosome 19q13

Cho

Castaldi

Hersh

et al. 2011

A95. Cutting Edge Insights to the Pathobiology of Copd and Interstitial Lung Disease

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The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely unknown. To date, genome-wide association studies (GWASs) of limited size have identified several novel risk loci for COPD at CHRNA3/CHRNA5/IREB2, HHIP and FAM13A; additional loci may be identified through larger studies. We performed a GWAS using a total of 3499 cases and 1922 control subjects from four cohorts: the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE); the Normative Aging Study (NAS) and National Emphysema Treatment Trial (NETT); Bergen, Norway (GenKOLS); and the COPDGene study. Genotyping was performed on Illumina platforms with additional markers imputed using 1000 Genomes data; results were summarized using fixed-effect meta-analysis. We identified a new genomewide significant locus on chromosome 19q13 (rs7937, OR 5 0.74, P 5 2.9 3 10 29 ). Genotyping this single * Molecular Genetics, 2012, Vol. 21, No. 4 947-957 doi:10.1093/hmg/ddr524 Advance Access published on November 11, 2011nucleotide polymorphism (SNP) and another nearby SNP in linkage disequilibrium (rs2604894) in 2859 subjects from the family-based International COPD Genetics Network study (ICGN) demonstrated supportive evidence for association for COPD (P 5 0.28 and 0.11 for rs7937 and rs2604894), pre-bronchodilator FEV 1 (P 5 0.08 and 0.04) and severe (GOLD 3&4) COPD (P 5 0.09 and 0.017). This region includes RAB4B, EGLN2, MIA and CYP2A6, and has previously been identified in association with cigarette smoking behavior.

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Section: Discussionmentioning

confidence: 99%

A Genome-Wide Association Study In COPD Identifies A Susceptibility Locus On Chromosome 19q13

Cho

Castaldi

Hersh

et al. 2011

A95. Cutting Edge Insights to the Pathobiology of Copd and Interstitial Lung Disease

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“…The male-to-female ratio of mortality from vascular disease is w3:1 throughout the world and this ratio is independent of the background prevalence of vascular disease and of other cardiovascular risk factors (1). Recently, three longitudinal epidemiological studies have found low testosterone levels to be associated with an increased risk of all-cause and cardiovascular mortality (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Long-term benefits of testosterone replacement therapy on angina threshold and atheroma in men

Mathur

Malkin²,

Saeed³

et al. 2009

European Journal of Endocrinology

135

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Introduction: In short-term studies, testosterone replacement therapy has been shown to protect male subjects from exercise-induced ischaemia and modify cardiovascular risk factors such as insulin resistance, fat mass and lipid profiles. Methods: This randomised parallel group controlled trial was designed to assess the treatment effect of testosterone therapy (Nebido) compared with placebo in terms of exercise-induced ischaemia, lipid profiles, carotid intima-media thickness (CIMT) and body composition during 12 months treatment in men with low testosterone levels and angina. Results: A total of 15 men were recruited but 13 (nZ13) reached adequate duration of follow-up; seven were treated with testosterone and six with placebo. Testosterone increased time to ischaemia (129G48 s versus 12G18, PZ0.02) and haemoglobin (0.4G0.6 g/dl versus K0.03G0.5, PZ0.04), and reduced body mass index (K0.3 kg/m 2 versus 1.3G1, PZ0.04) and triglycerides (K0.36

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“…De studiene som har vist en uavhengig assosiasjon mellom triglyserid og hjerte-og karsykdom, har også påvist at forhøyet nivå av triglyserid er farligere for kvinner enn for menn (7). Nyere data tyder også på at røyking er alvorligere for kvinner enn menn med hensyn til utvikling av hjerte-og karsykdom (1,8). Når det gjelder diabetes mellitus har man visst lenge at kvinner og menn med denne sykdommen er likestilt når det gjelder risiko for å utvikle hjerteinfarkt (1,9).…”

Section: Innledningunclassified

Kvinnehelse i Rogaland – kartlegging av risikofaktorer for hjerte- og karsykdom hos 200 kvinner i to kommuner i Rogaland

Fevang¹,

Schei²,

Grimstad³

2009

Nor J Epidemiol

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SAMMENDRAGFormålet med studien var å kartlegge nivået og forekomsten av risikofaktorene totalkolesterol, triglyserid, glukose, kroppsmasseindeks, blodtrykk og røyking. Studien ble gjort i samarbeid med Statens helseundersøkelser og var en utvidelse av 40-åringsundersøkelsene i to små øykommuner i Rogaland. Til undersøkelsen møtte 200 kvinner i alderen 15 til 75 år. Konsentrasjonen av totalkolesterol, triglyserid og glukose, samt verdien av kroppsmasseindeks og blodtrykk steg med stigende alder. Det var en signifikant positiv assosiasjon mellom kroppsmasseindeks og triglyserid og mellom kroppsmasseindeks og blodtrykk. Over 50% av kvinnene rapporterte god helse. Forekomsten av røyking var lavere enn ellers i landet. Kvinner som røykte eller som hadde enten totalkolesterol ≥ 5,7 mmol/l, triglyserid ≥ 2,3 mmol/l, glukose ≥ 11,1 mmol/l, kroppsmasseindeks ≥ 2,7 kg/cm 2 eller blodtrykk ≥ 140/90 mmHg ble klassifisert som å ha en eller flere risikofaktorer. I alt 71% av kvinnene i denne studien hadde en eller flere risikofaktorer. Sammenliknet med andre studier var nivået av risikofaktorene gjennomsnittlig. ENGLISH SUMMARYThe aims of the study were to report smoking habits and the levels of total cholesterol, triglyceride, blood sugar, blood pressure and body mass index. The study was carried out in cooperation with the National Health Screening Service. About 200 women, 15 to 75 years old, participated in the study. The concentration of total cholesterol, triglyceride, and blood sugar, and the levels of body mass index (BMI) and blood pressure increased with age. A statistically significant association was found between BMI and triglyceride, and between BMI and blood pressure. More than fifty percent of the women reported that their health was good. The proportion of women who reported cigarette smoking was lower than among women in a national sample. Women who smoked or had either total cholesterol ≥ 5.7 mmol/l, triglyceride ≥ 2.3 mmol/l, blood sugar ≥ 11.1 mmol/l, BMI ≥ 2.7 kg/cm 2 , or blood pressure ≥ 140/90 mmHg were classified as having one or more risk factors. In the present study 71% of the women had one or more of the risk faktors. The levels of the cardiovascular risk factors among the women in this study were comparable with levels among women in other studies. INNLEDNINGHjerte-og karsykdom er en viktig dødsårsak hos kvinner. Kartlegging av risikofaktorer for hjerte-og karsykdom hos kvinner har vist at de tradisjonelle risikofaktorene som gjelder for menn også gjelder for kvinner.Hypertensjon og forhøyet totalkolesterolnivå ser ut til å vaere like viktige risikofaktorer for hjerte-og karsykdom hos kvinner som hos menn (1-6). Det er ikke avklart om triglyserid er en uavhengig risikofaktor. De studiene som har vist en uavhengig assosiasjon mellom triglyserid og hjerte-og karsykdom, har også påvist at forhøyet nivå av triglyserid er farligere for kvinner enn for menn (7). Nyere data tyder også på at røyking er alvorligere for kvinner enn menn med hensyn til utvikling av hjerte-og karsykdom (1,8). Når det gjeld...

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Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction

Abstract: Smoking was a stronger risk factor for myocardial infarction in middle-aged women than in men. Relative risks associated with serum lipids and blood pressure were similar despite large sex differences in myocardial infarction incidence rates.

Cited by 340 publications

References 43 publications

A Genome-Wide Association Study In COPD Identifies A Susceptibility Locus On Chromosome 19q13

A Genome-Wide Association Study In COPD Identifies A Susceptibility Locus On Chromosome 19q13

Long-term benefits of testosterone replacement therapy on angina threshold and atheroma in men

Kvinnehelse i Rogaland – kartlegging av risikofaktorer for hjerte- og karsykdom hos 200 kvinner i to kommuner i Rogaland

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