Smoking Practices in Jordanian People and their Impact on Semen Quality and Hormonal Levels among Adult Men

Al-Matubsi, Hisham Y.; Kanaan, R.; Hamdan, Farqad B.; Salim, M. Fernández; Oriquat, Ghaleb A.; Hanbali, Othman A. Al

doi:10.21101/cejph.a3629

Cited by 30 publications

(28 citation statements)

References 27 publications

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“…Data from our results indicate that most infertile male were smoker 39(52%), that agreement with study of Al-Matubsi [54], and revealed significant low quality of sperm parameters in terms of semen volume, sperm count and motility in semen of infertile smokers. This finding is in accordance with those of some other studies [55,56,57].…”

Section: E-a Comparison Between Semen Parameters and Mda Among Fertilsupporting

confidence: 92%

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

AL-Naqshbandi¹,

AL-Barzinji²

2017

Cihan Univ.-Erbil Sci. J.

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Male infertility is an important medical and psychosocial problem worldwide. Therefore, it is important to identify new and non-conventional factors that may play significant role in male infertility. Current study focused on detecting more risk factors and markers for primary infertility in order to develop interventions for investigation and prevent their progressions. Oxidative stress has recently been identified as an underlying mechanism of numerous sources. The aim of the present study was therefore to evaluate whether there is an association between oxidative stress and male infertility in Erbil city subjects. The present prospective case control study was carried out between March to May 2013, in Maternity Teaching Hospital/in-vitro fertilization center and private clinical laboratory. 75 infertile males represent patients group were enrolled in this study. Apparently 40 healthy individuals who have no history of clinical evidence of any disease were also joined to this study as control group. Malondialdehyde (MDA), the marker of lipid peroxidation was measured in the seminal fluid of fertile and infertile male subjects. The sperm count, sperm morphology and motility, as well as semen volume were all found significantly lower in infertile subjects compared with fertile subjects (p<0.01). In seminal plasma, the MDA level was found significantly higher in infertile group (p<0.05). Lifestyle behaviours such as varicocele repair, cigarette smoking and alcohol consumption, all enhance the generation of ROS level in the seminal plasma, such elevation associated with decreased sperm quality particularly in term of sperm count and sperm motility that leading to increase male infertility.

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Section: E-a Comparison Between Semen Parameters and Mda Among Fertilsupporting

confidence: 92%

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

AL-Naqshbandi¹,

AL-Barzinji²

2017

Cihan Univ.-Erbil Sci. J.

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“…Studies of the effect of tobacco use on testosterone and LH levels have been conducted mainly among adult males, with inconsistent results (Simon et al 1992;Field et al 1994;Svartberg et al 2003;Funabashi et al 2006;Al-Matubsi et al 2011). For instance, a study conducted by Richtoff et al examined the effect of tobacco use on reproductive factors among Swedish male adolescents (Richthoff et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Associations between early alcohol and tobacco use and prolonged time to puberty in boys

Davis

Peck

et al. 2014

Child

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Background Previous research has demonstrated a relationship between prepubertal alcohol and tobacco use and delayed pubertal characteristics in females. Although, laboratory research indicates that alcohol and tobacco use inhibits sexual maturation in male rats, human research in this area is lacking. To address this question among males, we conducted a study to explore the association between early use of alcohol and tobacco and time to development of secondary sexual characteristics. Methods The study population included 3,199 males interviewed between the ages of 11 and 21. Participants reported the ages at which they first experienced body hair growth, deepening of the voice, and facial hair growth. Early alcohol and tobacco use were defined as first use preceding the age of pubertal development among those reporting regular consumption patterns. Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazard models. Results Early alcohol use was associated with longer time to body hair growth (HR 0.77; 95% CI 0.69–0.87), voice changes (HR 0.72; 95% CI 0.64–0.82), and facial hair growth (HR 0.77; 95% CI 0.68–0.86), after adjusting for tobacco use and age at interview. Tobacco use was not independently associated with the puberty indicators after controlling for alcohol use and age at interview. Conclusions Our findings are consistent with the hypothesis that alcohol may inhibit puberty onset in males, an association that has been previously observed among young females. Thus, alcohol may be an exposure deserving more scrutiny as a disruptor to normal pubertal development.

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“…Cigarette smoking is considered to be a risk to male infertility as it could be directly and indirectly toxic to spermatogenesis [4][5][6]. Even though the reason for the decline of semen quality remains unknown, the correlation between smoking and semen quality has been reported in many studies [7][8][9][10][11]. However, the effect of cigarette smoking on sperm quality reported by some studies was shown to be limited [12,13].…”

Section: Introductionmentioning

confidence: 99%

Cigarette smoking is associated with abnormal ferroptosis in human sperm

Ou¹,

Wen²,

Deng³

et al. 2020

Preprint

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Purpose The effects of cigarette smoking on male semen quality are controversial, and the molecular mechanisms underlying how cigarette smoking affects semen quality are not clear yet. Methods In this study, semen samples from 70 heavy smokers and 75 non-smokers receiving infertility treatment were included. Basic semen parameters in non-smokers and heavy smokers were evaluated. Levels of ferroptosis glutathione (GSH), lipid reactive oxygen species (ROS), iron and GSH-dependent peroxidase 4 (GPX4) protein level) were observed in human semen and in GC-2 Spd cells exposed to cigarette smoke condensate (CSC). Results Heavy smokers had significantly higher abnormalities (sperm viability and sperm progressive motility) than non-smoking counterparts. Comparing non-smokers group, GSH level was reduced in the group of heavy smokers (P<0.05). However, the level of lipid ROS and iron were significantly increased (P<0.05). Besides, GSH level was reduced following treatment with CSC for 24 h, while lipid ROS and iron levels were increased (P<0.05). However, the levels were reduced after being co-cultured with Ferrostatin-1 (Fer-1) (P<0.05). The level of GPX4 protein was reduced after being treated with CSC in 24 h, and increased after being co-cultured with Fer-1(P<0.05). Conclusion Cigarette smoking is associated with abnormalities of ferroptosis in human sperm.

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Smoking Practices in Jordanian People and their Impact on Semen Quality and Hormonal Levels among Adult Men

Cited by 30 publications

References 27 publications

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

The Seminal Plasma MDA Level as Bio-Marker for Oxidative Stress and Their Impact on Seminogram in Primary Infertile Males, Erbil-Kurdistan Region, Iraq

Associations between early alcohol and tobacco use and prolonged time to puberty in boys

Cigarette smoking is associated with abnormal ferroptosis in human sperm

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