Smoking, plasma cotinine and risk of atrial fibrillation: the Hordaland Health Study

Zuo, Hui; Nygård, Ottar; Vollset, Stein Emil; Ueland, Per Magne; Ulvik, Arve; Midttun, Øivind; Meyer, Klaus; Igland, Jannicke; Sulo, Gerhard; Tell, Grethe S.

doi:10.1111/joim.12689

Cited by 22 publications

(15 citation statements)

References 46 publications

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“…Italicization of the percentage denotes an assumption and the value in parentheses below it indicates the proportion of datapoints that relate to the actual product. points, based on the fact that most epidemiological studies did not differentiate between factory made and roll-your-own cigarettes and defined only "cigarette smoker" or "non-smoker", thus encompassing both products 27,31,35,40 . In addition, the consumption patterns and toxin emissions for these products are very similar and so it is reasonable to assume that the health outcomes would also be comparable.…”

Section: Combustible Tobacco Productsmentioning

confidence: 99%

Nicotine products relative risk assessment: a systematic review and meta-analysis

2020

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Background: Nicotine products have been the subject of considerable innovation over the past few decades. While the health risks of combustible cigarettes and most tobacco-based products are well characterized, there is less clarity regarding newer nicotine products, and how they compare with the traditional forms. Methods: In this study, we have developed a relative risk hierarchy (RRH) of 13 nicotine products based on systematic review of the scientific literature and analysis of the best available evidence. In total, 3980 publications were identified and screened, with 320 studies being carried through to the final analysis. The health risk data for each product was extracted and the level assessed. The products were analyzed in terms of their toxin emissions and epidemiological data, which were combined on an arbitrary scale from 0 to 100 (low to high risk) to derive a combined risk score for each nicotine product. Results: Combustible tobacco products dominate the top of the RRH, with combined risk scores ranging from 40 to 100. The most frequently consumed products generally score highest. Dipping and chewing tobacco place considerably lower on the hierarchy than the combustible products with scores of 10 to 15, but significantly above heat-not-burn devices and snus, which score between 3 and 4. The lowest risk products have scores of less than 0.25 and include electronic cigarettes, non-tobacco pouches and nicotine replacement therapy. Conclusions: The RRH provides a framework for the assessment of relative risk across all categories of nicotine products based on the best available evidence regarding their toxin emissions and the observed risk of disease development in product users. As nicotine products continue to evolve, and more data comes to light, the analyses can be updated to represent the best available scientific evidence.

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Section: Combustible Tobacco Productsmentioning

confidence: 99%

Nicotine products relative risk assessment: a systematic review and meta-analysis

2020

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“…5 For instance, cotinine has been associated with adverse health outcomes (eg, early abortions, atrial fibrillation, and all-cause mortality), but the underlying biology of these relationships remains poorly understood. 6,9,10 DNA methylation, an epigenetic modification, is a promising alternative to cotinine. Not only do DNA methylation levels reflect tobacco smoke exposure and smoking-related diseases, but existing technologies already enable researchers to explore nucleotide resolution changes in DNA methylation across the genome.…”

Section: Introductionmentioning

confidence: 99%

Relationships of Long-Term Smoking and Moist Snuff Consumption With a DNA Methylation Age Relevant Smoking Index: An Analysis in Buccal Cells

Nwanaji‐Enwerem

Chai

Weisskopf

et al. 2018

Nicotine &Amp; Tobacco Research

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Our findings demonstrate that this 66-CpG blood-derived SI can reflect long-term tobacco smoking, but not long-term snuff consumption, in buccal cells. This evidence will be useful as the field works to identify an accurate non-self-report smoking biomarker that can be measured in an easily accessible tissue. Future research efforts should focus on: (1) optimizing the relationship of the SI with DNAm-age so that the metric can maximize its utility as a tool for understanding general disease processes, and (2) determining normal values for the SI CpGs so that the measure is not as study sample specific.

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“…On the other hand, there have been several studies on the relationship between smoking and AF, 7 9 10 likely due to the clinical importance of fatal complications of AF, including stroke and heart failure. Although previous studies have shown inconsistent results, most of them have reported that smoking is associated with an increased risk of AF.…”

Section: Discussionmentioning

confidence: 99%

“…Until now, there has been a paucity of studies related to smoking and AA, other than a study of the association between smoking and supraventricular tachyarrhythmia in myocardial infarction patients with implanted cardioverter defibrillators. 5 Meanwhile, there have been several studies assessing the effects of cigarette smoking on atrial fibrillation (AF) that found conflicting results 6 7 8 9 and were mostly based on self-reported questionnaires. 5 6 7 8 10 Previous studies have reported misclassification of smoking status between self-reported questionnaires and biomarker verification.…”

Section: Introductionmentioning

confidence: 99%

Association of Self-Reported and Cotinine-Verified Smoking Status with Atrial Arrhythmia

et al. 2020

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Background: The relationship between self-reported and urinary cotinine-verified smoking status and atrial arrhythmia (AA) is unclear. The aim of this study was to evaluate the association of self-reported and urine cotinine-verified smoking status with AA. Method: A total of 201,788 participants (106,375 men, mean age 37 years) who had both a urinary cotinine measurement and electrocardiogram were included. Cotinine-verified current smoking was defined as a urinary cotinine level above 50 ng/mL. Individuals were divided into three groups based on self-reported smoking and two groups based on cotinineverified smoking status. Results: Among overall subjects, 505 had documented AA (0.3%) and 135 had atrial fibrillation (AF) (0.1%). Self-reported current smoking was associated with an increased risk of AA

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Smoking, plasma cotinine and risk of atrial fibrillation: the Hordaland Health Study

Cited by 22 publications

References 46 publications

Nicotine products relative risk assessment: a systematic review and meta-analysis

Nicotine products relative risk assessment: a systematic review and meta-analysis

Relationships of Long-Term Smoking and Moist Snuff Consumption With a DNA Methylation Age Relevant Smoking Index: An Analysis in Buccal Cells

Association of Self-Reported and Cotinine-Verified Smoking Status with Atrial Arrhythmia

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