Smoking, occupation, history of selected diseases and bladder cancer risk in Manisa, Turkey

Erdurak, Koray; Dündar, Pınar Erbay; Özyurt, Beyhan Cengiz; Negri, Eva; Vecchia, Carlo La; Tay, Ziya

doi:10.1097/cej.0b013e3283631dde

Cited by 16 publications

(12 citation statements)

References 23 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The incidence of BC in men is higher in the northwestern part of West Asia (Turkey and Lebanon) than in other parts, and cigarette smoking is proposed as the most important risk factor for BC in these countries [63, 64]. Among the current smokers with UBC in our study, the variant alleles of GSTM1 null, TP53 rs1042522Arg, and MTRR rs1801394G were more frequent than the wild-type alleles.…”

Section: Discussionmentioning

confidence: 55%

See 1 more Smart Citation

Combined Genetic Biomarkers Confer Susceptibility to Risk of Urothelial Bladder Carcinoma in a Saudi Population

et al. 2017

View full text Add to dashboard Cite

We evaluated the associations between seven single nucleotide polymorphisms and susceptibility to urothelial bladder carcinoma (UBC) in a Saudi population. Genomic DNA was taken from buccal cells of 52 patients with UBC and 104 controls for genotyping of GSTT1, GSTM1, rs4646903, rs1048943, TP53 rs1042522, rs1801133, and rs1801394 using PCR and TaqMan® assays. The rs1801133 and rs1801394 variants showed strong associations with UBC (OR = 2.3, P = 0.0002; OR = 2.6, P = 0.0001, resp.). Homozygosity of Pro72 conferred a significant double risk in cases compared with controls (30.8% versus 15.4%), but the homozygote Arg/Arg had no effect on risk. Genotypic combinations of GSTM1/GSTT1, rs4646903/rs1048943, and rs1801133/rs1801394 exhibited significant linkage with the disease (χ2 = 10.3, P = 0.006; χ2 = 13.9, P = 0.003; and χ2 = 20.4, P = 0.0004, resp.). The GSTM1 and rs1042522Arg and rs1801394G variant alleles were more frequent in current smokers with UBC (52.4%, 52.5%, and 64.3%, resp.) than were the corresponding wild-types. Despite some variants having only a slight effect on UBC risk, the interaction effect of combined genetic biomarkers—or even the presence of one copy of a variant allele—is potentially much greater. Perhaps more studies regarding next-generation genetic sequencing and its utility can add to the risk of UBC.

show abstract

Section: Discussionmentioning

confidence: 55%

“…Occupational exposure (e.g., to diesel) has also been suggested as a risk factor for BC [64]. However, any effect of occupational history in our study was clearly passive, as these UBC patients were working in business affairs (92.3%) or as house wives (7.7%).…”

Section: Discussionmentioning

confidence: 64%

Combined Genetic Biomarkers Confer Susceptibility to Risk of Urothelial Bladder Carcinoma in a Saudi Population

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Furthermore, we selected all male participants and matched the gout patients and nongout controls to the same age and diagnosis date to avoid confounding results. However, there were many risk factors associated with bladder cancer that were not avoided in the current study such as smoking, education, or intake of vitamin C (Erdurak et al, 2014;Ryu et al, 2014), as the outpatient data did not provide sufficient information on these behaviors. This study evaluated the effect of allopurinol or benzbromarone use on the development of incident cancers.…”

Section: Discussionmentioning

confidence: 70%

Allopurinol and the incidence of bladder cancer

Chen

Hsieh

Liao

et al. 2016

European Journal of Cancer Prevention

View full text Add to dashboard Cite

Our aim is to investigate the risk association between allopurinol use and cancer incidence among gout patients using clinical evidence. Newly diagnosed male patients with gout, 20 years or older, were included after excluding those who had a diagnosis of type 2 diabetes, and were followed up for 12 years in a retrospective cohort study of one million outpatients of a national database. The gout patients were matched to male controls by age and first diagnosis date of gout disease. We then estimated the risk associations between incident cancers and duration of allopurinol use by Cox hazard regression, age-adjusted standardized incidence ratio, and incidence per 1000 person-years. A total of 24 050 gout patients and 76 129 controls were included. The incidence of all-cause cancers for gout patients and controls was 8.26 cases and 7.49 cases/1000 person-years, respectively; it was markedly increased in gout patients who used allopurinol for over 90 days. The hazard ratio of all-cause cancers was 1.21 (95% confidence interval=1.03-1.42, P=0.019) after adjustment for age and 2.26 for bladder cancer (95% confidence interval=1.32-3.87, P=0.003) on comparing those who used allopurinol for over 90 days with nonusers. Meanwhile, other cancers did not show the same significant result. We concluded that those who used allopurinol for a long duration had a higher occurrence of both bladder cancer and all-cause cancers in clinical evidence.

show abstract

“…[7][8][9]31 In the Dutch study by Vermeulen et al, 7 only 15 of the included 1,767 bladder cancer cases had SCC. In contrast, previous smaller case-control studies have focused only on urothelial carcinomas 11 or on bladder cancer overall.…”

Section: Discussionmentioning

confidence: 99%

Urinary tract infections and risk of squamous cell carcinoma bladder cancer: A Danish nationwide case–control study

Pottegård

Kristensen

Friis

et al. 2020

Intl Journal of Cancer

View full text Add to dashboard Cite

Schistosoma haematobium infection can lead to squamous cell carcinomas (SCC) of the bladder. Whether this also applies to more common urinary tract infections (UTIs) is unclear. We therefore aimed to investigate the association between UTIs, reflected by the use of specific antibiotics and risk of SCC of the bladder. We conducted a Danish nationwide case-control study and identified histologically verified bladder cancer cases (2000-2015; n = 12,271) and age-and sex-matched cancerfree controls. We computed odds ratios (ORs) with 95% confidence intervals (CI) associating the use of UTI-specific antibiotics with SCC bladder cancer, using conditional logistic regression. We applied a 2-year lag-time to minimize reverse causation. To aid interpretation, similar analyses were performed for other bladder cancer types and other antibiotics. We identified 333 SCC cases (2.7% of all bladder cancers). Compared to no use (0-1 prescription), high-use (≥10 prescriptions) of UTI-specific antibiotics was associated with SCC with an OR of 11.4 (CI 7.6-17.2) and a clear dose-response pattern (p trend < 0.001). Use of phenoxymethylpenicillin, an antibiotic not used against UTIs, was not associated with SCC after adjustment for use of UTIspecific antibiotics (OR 0.5). Furthermore, UTI-specific antibiotic use was not associated with urothelial carcinomas (n = 11,029; OR 1.13; CI 0.97-1.32). Excluding patients with known urogenital disease did not influence the SCC estimates (overall OR 10.8; CI 6.2-18.9). Data on smoking were lacking, however, a quantitative bias analysis suggested this to be of limited importance. In conclusion, common UTIs are strong, dose-dependent and specifically associated with risk of SCC of the bladder.Additional Supporting Information may be found in the online version of this article.

show abstract

Smoking, occupation, history of selected diseases and bladder cancer risk in Manisa, Turkey

Cited by 16 publications

References 23 publications

Combined Genetic Biomarkers Confer Susceptibility to Risk of Urothelial Bladder Carcinoma in a Saudi Population

Combined Genetic Biomarkers Confer Susceptibility to Risk of Urothelial Bladder Carcinoma in a Saudi Population

Allopurinol and the incidence of bladder cancer

Urinary tract infections and risk of squamous cell carcinoma bladder cancer: A Danish nationwide case–control study

Contact Info

Product

Resources

About