Smoking modulates neuroendocrine responses to ipsapirone in patients with panic disorder

Broocks, Andreas; Hajak, Göran; Bandelow, Borwin; Koch, K.; Schweiger, Ulrich; Hohagen, Fritz

doi:10.1016/s0924-9338(02)80813-6

Cited by 3 publications

(3 citation statements)

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“…We believe that adoption of this point of view will afford a better understanding of the pathophysiology of PTSD as well as the high comorbidity between smoking dependence and PTSD. In addition, application of techniques for characterizing the smoking patterns of research participants should be extended to studies of the neurobiological basis for other anxiety disorders (Breslau and Klein, 1999;Johnson et al, 2000;Broocks et al, 2002;Isensee et al, 2003;Schumann et al, 2004;McCabe et al, 2004). We hope that investigation of the relationship between nicotine dependence and PTSD or other anxiety disorders will lead to new methods of prevention and treatment of these severely debilitating and costly neuropsychiatric conditions.…”

Section: Resultsmentioning

confidence: 99%

Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review

Rasmusson

Picciotto²,

Krishnan‐Sarin

2006

J Psychopharmacol

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As smoking rates in the general population continue to fall in response to new information and changing social values, the continued high rate of smoking among persons with psychiatric disorders has caught the attention of society at many levels: public health officials, medical and mental health care providers, and concerned family members alike. As a consequence, research studies aimed at quantifying the problem and understanding its cause have increased dramatically over the past several years. The following review first examines epidemiological studies that have revealed a bidirectional causal relationship between tobacco dependence and posttraumatic stress disorder (PTSD), one of several mental health disorders in which tobacco dependence remains prevalent and resistant to intervention. Second, we use a translational neuroscience perspective to discuss possible neurobiological mediators of the relationship between PTSD and tobacco dependence, hoping to spur further human and animal research that will elucidate pathogenetic mechanisms involved and inspire novel treatment interventions. Finally, to enable more effective clinical research in this area, we provide an overview of effective scientific methods for assessing and managing 'smoking status' as an experimental variable in clinical research studies of PTSD as well as other mental health disorders.

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Section: Resultsmentioning

confidence: 99%

Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review

Rasmusson

Picciotto²,

Krishnan‐Sarin

2006

J Psychopharmacol

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“…Several lines of evidence suggest that serotonergic neurotransmission, including the regulation of 5-HT1A receptors, is affected by nicotine [39]. Recent studies showed that some of nicotine's psychotropic and endocrine effects are exerted by stimulation of 5-HT1A receptors on dorsal raphe neurons [40]. Increased cortisol secretion may play a role by inducing tryptophan 2,3-dioxygenase (tryptophan pyrrolase), the main metabolizing enzyme of tryptophan.…”

Section: Discussionmentioning

confidence: 99%

Influence of Altered Hormonal Status on Platelet 5-HT and MAO-B Activity in Cigarette Smokers

et al. 2014

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The present study was designed to understand the cigarette smoking-induced alterations in hormones and the resulting changes in platelet serotonin (5-hydroxytryptamine, 5-HT) and monoamine oxidase (MAO-B) activity in chronic smokers. Human male volunteers aged 35 ± 8 years, were divided into two groups, namely controls and smokers (12 ± 2 cigarettes per day for 7-10 years). Results showed that cigarette smoking significantly (p < 0.05) elevated plasma triiodothyronine (T3), cortisol and testosterone levels with significant (p < 0.05) reduction in plasma tryptophan and thyroxin (T4). Moreover, smokers showed reduced platelet 5-HT levels and MAO-B activity. In smokers, plasma cortisol was negatively correlated with tryptophan (r = -0.386), platelet MAO-B (r = -0.264), and 5-HT (r = -0.671), and positively correlated with testosterone (r = 0.428). However, testosterone was negatively correlated with platelet MAO-B (r = -0.315), and 5-HT (r = -.419) in smokers. Further, smokers plasma T3 levels were negatively correlated with platelet MAO-B (r = -0.398), and 5-HT (r = -0.541), whereas T4 levels were positively correlated with platelet MAO-B (r = 0.369), and 5-HT (r = 0.454). In conclusion, our study showed that altered testosterone and cortisol levels may aggravate behavior, mood disturbances and symptoms of depression by decreasing platelet 5-HT and MAO-B activity in smokers.

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“…Heavy smoking in adolescence is associated with a higher risk of panic disorder, generalized anxiety disorder and agoraphobia [103]. Patients who were smokers had reduced baseline concentrations of cortisol and had higher cortisol responses to ipsapirone than nonsmokers [104], suggesting differential responses among subgroups of smoking patients with panic disorder. Unfortunately, there is a paucity of tobacco addiction treatment studies for smokers with anxiety disorders.…”

Section: Anxiety Disordersmentioning

confidence: 99%

Management of smoking in people with psychiatric disorders

Ziedonis¹,

Williams²

2003

Current Opinion in Psychiatry

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Purpose of reviewThe rates of tobacco addiction in individuals with psychiatric disorders (mental illness and addiction) continue to remain alarmingly high despite substantial decreases in smoking in the general population. Recent findings suggest that tobacco addiction treatment can be effective for smokers with psychiatric disorders, but will require both clinical interventions and systems changes. There is both an immediate need to address tobacco in this population and to expand research agendas to include the many remaining clinical questions for this population. Recent findingsNearly half of all cigarettes consumed in the United States are smoked by individuals with psychiatric disorders, who are at two to three times the risk of developing tobacco-related medical illnesses. Recent international studies have found high rates of heavy smoking among those with psychiatric disorders similar to those in the United States. Under-recognition and under-treatment of tobacco addiction in this population continues to be common despite the availability of effective management approaches. Smokers with psychiatric disorders are a broad treatment population that requires treatment specificity according to subtypes. Nicotine replacement medication, bupropion, atypical antipsychotics, and modified psychosocial treatments can improve outcomes. The effective model programs and system changes that have begun to address tobacco in this population have often not been published, disseminated, or replicated. Summary There continue to be relatively few treatment studies for this population, and the existing studies have small sample sizes. Research should test whether effective treatments used in the general population will work for this population. Program development and system changes should be described and evaluated. Abbreviations CBTcognitive behavioral therapy FDA Food and Drug Administration NRT nicotine replacement therapy SSRI selective serotonin reuptake inhibitor

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Smoking modulates neuroendocrine responses to ipsapirone in patients with panic disorder

Cited by 3 publications

References 0 publications

Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review

Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review

Influence of Altered Hormonal Status on Platelet 5-HT and MAO-B Activity in Cigarette Smokers

Management of smoking in people with psychiatric disorders

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