Smoking Increases the Treatment Failure for Helicobacter pylori Eradication

Helicobacter pylori eradication: A randomised comparative trial of 7-day versus 14-day triple therapy

“…Smoking is an independent risk factor for H. pylori treatment failure. 7 In contrast, alcohol consumption may facilitate elimination of H. pylori infection among adults. 8 All patients who had dyspepsia and were referred for endoscopy had H. pylori-positive gastritis.…”

Clinical Factors Related with Helicobacter Pylori Infection - Is there an Association with Gastric Cancer History in First-Degree Family Members?

“…Beyond the influence on H pylori infection, recent literature emphasize on the contribution of smoking behavior to the increased risk of gastric carcinogenesis from gastric atrophy (Hishida et al, 2010). However, evidence from recent literature suggests that smoking is one of the factors associated with therapy failure in H pylori eradication (Suzuki et al, 2006;Gasparetto et al, 2012). The most possible cause may be attributable to a reduction in antibiotic delivery due to decreased gastric blood flow and decreased in intragastric pH in cases of smoking (Malfertheiner et al, 2012).…”

Helicobacter pylori Eradication in Patients with an Iatrogenic Ulcer after Endoscopic Resection and Peptic Ulcer

“…Several factors are reportedly associated with a decreased efficacy of H. pylori eradication therapy, including antibiotic resistance, CYP2C19 polymorphisms, MDR1 C3435T polymorphism, eradication duration, smoking, and probiotics. [23][24][25][26][27][28] Drug compliance was also found to be a risk factor of eradication failure. 12,29 To minimize the effects of these factors, we chose the same regimen with a 7-day duration in all the patients.…”