Smoking, diabetes, blood hypertension: possible etiologic role for Peyronie’s disease? Analysis in 279 patients with a control group in Sicily

Pavone, Carlo; D’Amato, Francesco; Dispensa, Nino; Torretta, Federico; Magno, Carlo

doi:10.4081/aiua.2015.1.20

Cited by 21 publications

(18 citation statements)

References 20 publications

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“…A retrospective case–control study showed that smoking was associated with PD (Bjekic et al, ). An another comparative clinical study showed that smoking was statistically higher in patients with PD than healthy population (Pavone et al, ). However, we did not find a significant relationship between smoking and PD ( p = 0.375).…”

Section: Discussionmentioning

confidence: 99%

“…There are many studies which have investigated comorbidities accompanying with PD. Recent studies showed that HT and BMI have significantly higher ratio in patients with PD (Pavone, D'Amato, Dispensa, Torretta, & Magno, ; Ventimiglia et al, ). However, in a prospective study, Cavallini et al () showed that BMI and HT were not associated with PD.…”

Section: Discussionmentioning

confidence: 99%

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Is high levels of vitamin D a new risk factor for Peyronie's disease?

et al. 2019

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The aim of this study is to investigate whether serum vitamin D level predicts the risk of Peyronie's disease. Calcium and inflammatory cytokines play an important role during fibrocalcification of the plaques in Peyronie's Disease. TGF-β1 is one of the most fibrogenic cytokines. Increasing serum vitamin D levels is considered that induce expression of TGF-β1. Serum vitamin D levels and TGF-β1 are related with calcifications of some soft tissues in previous studies. One hundred and three Peyronie patients and 162 healthy volunteers were included in the study. In both groups, demographic data, medical history, physical examination and erectile capacity were recorded. Serum 25-hydroxyvitamin D, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglyceride and testosterone levels were measured. The mean level of serum 25 (OH) D was significantly higher in men with Peyronie's disease compared with the controls (32.6 ± 7.9 ng/ml vs. 18.5 ± 6.6 ng/ml respectively. p < 0.001). There is a relationship between Peyronie's disease and high serum vitamin D levels. Also, increased low-density lipoprotein and total cholesterol levels, diabetes mellitus, and cardiovascular diseases were associated with Peyronie's disease. K E Y W O R D Spenile curvature, Peyronie's disease, plaque, vitamin D (Bollineni & Reddi, 1993). In addition, the severity of PD may correlate with DM has been shown (Kendirci, Trost, Sikka, & Hellstrom, 2007). In our study, 6.2% of patients had DM in control group and 26.2% of patients had DM in PD group (p < 0.001).Aetiologic impact of smoking is unclear in PD. Smoking has been shown as a PD risk factor in some studies. A retrospective case-control study showed that smoking was associated with PD (Bjekic et al., 2006). An another comparative clinical study showed that smoking was statistically higher in patients with PD than healthy population (Pavone et al., 2015). However, we did not find a significant relationship between smoking and PD (p = 0.375). Similarly, the impact of alcohol using is uncertain, although there are some studies showing that alcohol consumption is a risk factor for PD. Bjekic et al. found that alcohol consumption was related with PD (Bjekic et al., 2006).However, in the present study our results do not support this association (p = 0.468).Cholesterol is known a precursor of steroid hormones and has important roles in body metabolism. Hypercholesterolaemia and increased LDL levels are related with hyperlipidemia. Hyperlipidaemia is well known as a risk factor for vascular diseases. CVD is considered to lead of vascular weakness and facilitate the vascular damages during sexual intercourse. Therefore, hyperlipidaemia and CVD are risk factors for PD according to previous studies (Bjekic et al., 2006;Kadioglu et al., 2002;Muralidhar, Kumar, Sharma, Sharma, & Mandai, 1997). In our study, we found that increased CVD rates and high LDL/ total cholesterol levels were associated with PD.Our study has several limitations. Firstly, serum calcium and cavernosal TGF-β1 levels...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Is high levels of vitamin D a new risk factor for Peyronie's disease?

et al. 2019

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“…Epidemiological studies have objectifi ed the association of PD and cardiovascular risk factors such as diabetes, hypertension, dyslipidemia, chronic smoking [8,9]. This is how Carlo and Al [10], in Italy in 2015 found diabetes to have 21% frequency, 57% hypertension and Tobacco 64%. Shiaraishi and Japan [11], reported diabetes, hypertension and tobacco respectively in 32.5%, 58% and 24%.…”

Section: Discussionmentioning

confidence: 99%

Assessment of sexuality in patients with Peyronie’s disease

Rachid¹,

Gallouo²,

Graiouid³

et al. 2020

Int J Sex Reprod Health Care

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Introduction: Peyronie's disease is an acquired fi brosis of the corpora cavernosa which causes deformation of the penis and represents one of the causes of erectile insuffi ciency with serious consequences for the life of a couple. The diagnosis is clinical and the treatment is medico-surgical. Objective: Evaluation of the sexuality of patients with Peyronie's disease. Patients and methods: This prospective study occured from February 2017 to December 2019 including patients suffering all from Peyronie's Disease (PD). The IIEF (International Index of Erectile Function), EHS (Erection Hardness Score) and T LUE scores were used to assess erectile function and the severity of PD. The preestablished data were: Age, co-morbidities, delays, medical background, the onset mode, data from the penis examination in the fl accid state and in erection, general examination and therapeutic management. Results: We listed 20 patients; the average age is 58.2years (39-69years). The onset was progressive in 80% of the patients; the average consultation time was 14.1 months. Deformation was the most frequent symptom in 70% of cases, followed by the coital discomfort in 50%. Intromission was accompanied by a discomfort in 60%. In 80% of patients the disease was at the sclerotic stage. Palpation of the plaque was found in 60% of patients. The IIEF score was 14,6 and 80% of patients had erectile dysfunction, 40% of which was moderate. Grade 4 EHS was predominant in 60%, pain was mild in erection in 40% case. Dyspareunia has been reported by 60% of partners. Medical treatment was prescribed for 60% of our patients, 40% of whom received medical treatment for the dysfunction. Conclusions: PD signifi cantly alters the sexual and relational quality of patient's lives.

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“…An accurate demographic, clinical history and physical examination were recorded during the first visit. The subjective pain during an erection was evaluated by means of the visual analogue scale (VAS); with 0 as no pain and 10 as maximum pain, 4 classes of pain were identified: severe pain (8-10), mild pain (5-7), low-mild pain (2)(3)(4), and low/no pain (0-1). 18 The plaque size was measured (in mm) with penile ultrasonography (with a 7.5 to 12 MHz linear transducer for small organs and superficial lesions).…”

Section: Study Protocolmentioning

confidence: 99%

“…1,2 The prevalence of PD in the general population ranges from 0.39% to 7.1%, but it goes up to 20.3% in diabetic patients with Erectile Dysfunction (ED). 3 Its pathogenesis stands poorly understood and various theories have been proposed in this regard. 4 Most urologists support the logic of a combination of microtrauma during sexual activity in a susceptible case, which would lead to deregulation of the scarring process and formation of the plaque.…”

Section: Introductionmentioning

confidence: 99%

Laser Therapy for Peyronie’s Disease: A Randomized Control Double-Blind Pilot Study

et al. 2019

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Introduction: The management of Peyronie’s disease (PD) has remained a therapeutic dilemma for physicians and there is no gold standard treatment. In this paper, we decided to investigate the beneficial effect of the intralesional administration of verapamil compared with the intralesional administration of verapamil plus a low-intensity laser (LIL). Methods: Research was activated from May 2016 to May 2018 and a total of 38 men aged 18 years and older completed the investigation. The subjects were randomly divided into 2 groups. Group 1 was composed of 22 patients that were treated only by verapamil (5 mg) plus a sham laser weekly for 6 weeks, and group 2 consisted of 22 patients that received a laser, using the BTL–6000 HIGH-INTENSITY LASER 12 W machine and the same protocol of intralesional verapamil injection. The visual analogue scale (VAS) was used to evaluate pain during an erection, penile ultrasonography was used to measure plaque size, the penile curvature angle degree was measured using the photographs taken during an erection, and the International Index of Erectile Function questionnaire was used to assess erectile function. The follow-up treatment lasted for nine months, with visits performed in the 3rd and 9th months. Results: All study parameters decreased significantly after treatment in both arms, but the reduction in pain and penile curvature improvements in combination therapy revealed more significant changes in 3 months (p = .035, p=.032). Nevertheless, these improvements were not seen in the follow-up session after 9 months. Conclusion: A laser appears to be safe treatment modality in carefully-selected patients with PD. It has moderate efficacy in the short term.

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Smoking, diabetes, blood hypertension: possible etiologic role for Peyronie’s disease? Analysis in 279 patients with a control group in Sicily

Cited by 21 publications

References 20 publications

Is high levels of vitamin D a new risk factor for Peyronie's disease?

Is high levels of vitamin D a new risk factor for Peyronie's disease?

Assessment of sexuality in patients with Peyronie’s disease

Laser Therapy for Peyronie’s Disease: A Randomized Control Double-Blind Pilot Study

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