Smoking Compromises Cause-specific Survival in Patients with Operable Colorectal Cancer

Lifestyle factors associated with survival after colorectal cancer diagnosis

“…Our finding of increased mortality in colorectal cancer patients who are current smokers is consistent with some (Munro et al , 2006; Phipps et al , 2011, 2013), but not all (Yu et al , 1997; Park et al , 2006; McCleary et al , 2010; Nordenvall et al , 2013), previous research on this topic. Two studies have found that colon/colorectal cancer patients who were current smokers had poorer survival than those who were non-smokers (Munro et al , 2006; Phipps et al , 2013), whereas another study found that colon cancer-specific mortality, but not rectal cancer-specific mortality, was higher in current smokers than in never or former smokers (Phipps et al , 2011).…”

“…Two studies have found that colon/colorectal cancer patients who were current smokers had poorer survival than those who were non-smokers (Munro et al , 2006; Phipps et al , 2013), whereas another study found that colon cancer-specific mortality, but not rectal cancer-specific mortality, was higher in current smokers than in never or former smokers (Phipps et al , 2011). The remaining four studies found no association between current smoking and survival in colorectal cancer patients (Yu et al , 1997; Park et al , 2006; McCleary et al , 2010; Nordenvall et al , 2013).…”

Fistula-associated anal adenocarcinoma in Crohnʼs disease

“…Smoking status was documented in all 6 patients undergoing surgery at our institution and in all 21 patients reported by Devon et al 12 and Gaertner et al 26 Smoking status also correlated significantly with the presence of perirectal lymph node metastases, which was the strongest predictor of poor outcome both by univariate and multivariate analysis. Although cigarette smoking has been found to be associated with an increase in colorectal cancer incidence and mortality in the general population, [42][43] it cannot be concluded definitely whether cigarette smoking independently influences the oncological outcome in CD patients with FAAA because of the low number of cases in the present study. Close attention should be paid to this variable in patients with CD.…”

The Impact of Perioperative Risk, Tumor Pathology and Surgical Complications on Disease Recurrence Following Potentially Curative Resection of Colorectal Cancer

“…There is now consistent evidence that cigarette smoking increases the risk of postoperative complications after a range of surgical procedures, including colorectal cancer surgery. [21][22][23] There is also evidence that smoking shortens survival after curative resection of colorectal cancer 24,25 ; this study suggests the mechanism behind this association may be an increased risk of systemic metastases. Previous studies have reported that postoperative complications are associated with poorer long term survival after major surgery.…”