Smoking cessation effectiveness in smokers with COPD and asthma under real life conditions

Gratziou, C.; Florou, A.; Ischaki, Eleni; Eleftheriou, Konstantinos; Sachlas, Athanasios; Bersimis, Sotiris; Zakynthinos, Spyros

doi:10.1016/j.rmed.2014.01.007

Cited by 31 publications

(17 citation statements)

References 36 publications

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“…Cigarette smoking is detrimental to health and linked to adverse health outcomes, including lung and other cancers, 45 – 47 asthma, 48 chronic obstructive pulmonary disease, 48 autoimmune diseases, 49 and adverse fertility outcomes in women 50 and men, 51 both in smokers themselves and those exposed to secondhand smoke. Cigarette smoking is associated with deleterious effects on ovarian steroidogenesis and gametogenesis, oocyte maturity, ovulation, fertilization, and implantation.…”

Section: Cigarette Smoking In Pregnancy: Known Risks To Fetal Health mentioning

confidence: 99%

Altered placental DNA methylation patterns associated with maternal smoking: current perspectives

Maccani¹,

Maccani²

2015

AGG

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The developmental origins of health and disease hypothesis states that adverse early life exposures can have lasting, detrimental effects on lifelong health. Exposure to maternal cigarette smoking during pregnancy is associated with morbidity and mortality in offspring, including increased risks for miscarriage, stillbirth, low birth weight, preterm birth, asthma, obesity, altered neurobehavior, and other conditions. Maternal cigarette smoking during pregnancy interferes with placental growth and functioning, and it has been proposed that this may occur through the disruption of normal and necessary placental epigenetic patterns. Epigenome-wide association studies have identified a number of differentially methylated placental genes that are associated with maternal smoking during pregnancy, including RUNX3, PURA, GTF2H2, GCA, GPR135, and HKR1. The placental methylation status of RUNX3 and NR3C1 has also been linked to adverse infant outcomes, including preterm birth and low birth weight, respectively. Candidate gene analyses have also found maternal smoking-associated placental methylation differences in the NR3C1, CYP1A1, HTR2A, and HSD11B2 genes, as well as in the repetitive elements LINE-1 and AluYb8. The differential methylation patterns of several genes have been confirmed to also exhibit altered gene expression patterns, including CYP1A1, CYP19A1, NR3C1, and HTR2A. Placental methylation patterns associated with maternal smoking during pregnancy may be largely gene-specific and tissue-specific and, to a lesser degree, involve global changes. It is important for future research to investigate the mechanistic roles that these differentially methylated genes may play in mediating the association between maternal smoking during pregnancy and disease in later life, as well as to elucidate the potential influence of emerging tobacco product use during pregnancy, including the use of electronic cigarettes, on placental epigenetics.

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Section: Cigarette Smoking In Pregnancy: Known Risks To Fetal Health mentioning

confidence: 99%

Altered placental DNA methylation patterns associated with maternal smoking: current perspectives

Maccani¹,

Maccani²

2015

AGG

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“…In Australia, a study of practice nurse-delivered smoking cessation, including the offer of free nicotine patches, found a continuous abstinence rate of 16% (22% using point prevalence) after 6 months [29]. In Greece, a study on smokers with COPD and asthma found a 6 month continuous abstinence rate of 28.9% in smokers with COPD [30]. Compared in a Danish context results from the Danish Smoking Cessation Database primarily covering the smoking cessation activity in the municipalities showed an overall 6 month quit rate of 27% (ITT) using data from the period 2006e2011 [9], and an overall 12 month quit rate of 18% using data from the period 2001e2002 [10].…”

Section: Bi-variate Predictor Analysesmentioning

confidence: 99%

“…However, long-term follow-up of smoking cessation activities is in general rather effective in Denmark -both in the GP setting as well as in the municipality smoking cessation clinics setting e resulting in low drop-out rates. For comparison the Danish Smoking Cessation Database covering the smoking cessation activity of the municipality smoking cessation clinics did in 2013 reported a 16% drop-out rate at the 6 month follow-up for smokers included and following the clinics' 3-month quit program [30]. Repeated telephone calls to the participants (up to four times with one of them being in the evening) is the explanation to this low drop-out rate at 6 month followup from Danish smoking cessation activities.…”

Section: Bi-variate Predictor Analysesmentioning

confidence: 99%

Real-life effectiveness of smoking-cessation treatments in general practice clinics in Denmark. The Escape Smoke project

Poulsen¹,

Spillemose

Nielsen³

et al. 2015

Respiratory Medicine

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“…In a retrospective, observational study, Gratziou and colleagues reported that the prevalence of depression among COPD patients with severe airway obstruction (FEV 1 < 50%) was 25% and they had a 2.5 times greater risk of depression in comparison to healthy smokers [7]. High prevalence of depression is independently associated with smoking [8] and failure to quit [9].…”

Section: Introductionmentioning

confidence: 99%

Depression, anxiety and panic disorders in chronic obstructive pulmonary disease patients: correlations with tobacco use, disease severity and quality of life

Pascal¹,

Trofor²,

Lotrean³

et al. 2017

Tob. Induced Dis.

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BackgroundThe objective of this study is to assess anxiety, depression and panic disorders among patients diagnosed with COPD and to investigate their correlation with disease severity, quality of life as well as tobacco use.MethodsAn observational study was performed between January and September 2014 among 60 patients diagnosed with COPD. COPD staging according to GOLD criteria, while anxiety and depression were assessed using Hospital Anxiety and Depression Scale and panic attacks were evaluated based on ICD 10 criteria.ResultsAlmost 40% of the sample were smokers, the medium packs-years was 34.3 and the medium Fagerstrom score was 7.5. Overall, mean Modified Medical Research Council Dyspnea Scale (mMRC) was 2.86, mean COPD Assessment Test (CAT) score was 21.75 and study participants had 1.93 COPD exacerbations/year. Mean distribution of anxiety and depression symptoms scores among COPD subjects was 10.65 ± 3.5 and 9.93 ± 3.8, respectively. Smokers and ex-smokers had similar scores with regard to anxiety, depression or the presence of panic attacks. The results of the bivariate correlations indicated associations between anxiety, depression, panic attacks and disease severity, as well as poor quality of life of patients with COPD, regardless of their current tobacco use status.ConclusionsIn conclusion, the results of this study indicate that anxiety, depression and panic attacks were constant characteristics among COPD patients- regardless of their current tobacco use.

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Smoking cessation effectiveness in smokers with COPD and asthma under real life conditions

Abstract: The results support the view that smokers with respiratory obstructive airway diseases of any severity should be offered an intensive smoking cessation program with regular and long-term follow-up. This will help them to achieve high abstinence rates and prevent relapses.

Cited by 31 publications

References 36 publications

Altered placental DNA methylation patterns associated with maternal smoking: current perspectives

Altered placental DNA methylation patterns associated with maternal smoking: current perspectives

Real-life effectiveness of smoking-cessation treatments in general practice clinics in Denmark. The Escape Smoke project

Depression, anxiety and panic disorders in chronic obstructive pulmonary disease patients: correlations with tobacco use, disease severity and quality of life

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