Smoking cessation and vaccination

de, María Montes; Laucho-Contreras, María E.

doi:10.1183/16000617.0187-2022

Cited by 6 publications

(2 citation statements)

References 103 publications

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“…Additionally, other studies suggest that TD may exacerbate the severity and progression of COPD [34]. Among individuals diagnosed with COPD, the presence of TD makes quitting smoking more challenging [35]. Thus, this study underscores the critical importance of addressing TD in the management and mitigation of COPD.…”

Section: Principal Findingsmentioning

confidence: 68%

Mediating Effect of Tobacco Dependence on the Association Between Maternal Smoking During Pregnancy and Chronic Obstructive Pulmonary Disease: Case-Control Study

Li,

Xu,

Yang

et al. 2024

JMIR Public Health Surveill

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Background Maternal smoking during pregnancy (MSDP) is a known risk factor for offspring developing chronic obstructive pulmonary disease (COPD), but the underlying mechanism remains unclear. Objective This study aimed to explore whether the increased COPD risk associated with MSDP could be attributed to tobacco dependence (TD). Methods This case-control study used data from the nationwide cross-sectional China Pulmonary Health study, with controls matched for age, sex, and smoking status. TD was defined as smoking within 30 minutes of waking, and the severity of TD was assessed using the Fagerstrom Test for Nicotine Dependence. COPD was diagnosed when the ratio of forced expiratory volume in 1 second to forced vital capacity was <0.7 in a postbronchodilator pulmonary function test according to the 2017 Global Initiative for Chronic Obstructive Lung Disease criteria. Logistic regression was used to examine the correlation between MSDP and COPD, adjusting for age, sex, BMI, educational attainment, place of residence, ethnic background, occupation, childhood passive smoking, residential fine particulate matter, history of childhood pneumonia or bronchitis, average annual household income, and medical history (coronary heart disease, hypertension, and diabetes). Mediation analysis examined TD as a potential mediator in the link between MSDP and COPD risk. The significance of the indirect effect was assessed through 1000 iterations of the “bootstrap” method. Results The study included 5943 participants (2991 with COPD and 2952 controls). Mothers of the COPD group had higher pregnancy smoking rates (COPD: n=305, 10.20%; controls: n=211, 7.10%; P<.001). TD was more prevalent in the COPD group (COPD: n=582, 40.40%; controls: n=478, 33.90%; P<.001). After adjusting for covariates, MSDP had a significant effect on COPD (β=.097; P<.001). There was an association between MSDP and TD (β=.074; P<.001) as well as between TD and COPD (β=.048; P=.007). Mediation analysis of TD in the MSDP-COPD association showed significant direct and indirect effects (direct: β=.094; P<.001 and indirect: β=.004; P=.03). The indirect effect remains present in the smoking population (direct: β=.120; P<.001 and indirect: β=.002; P=.03). Conclusions This study highlighted the potential association between MSDP and the risk of COPD in offspring, revealing the mediating role of TD in this association. These findings contribute to a deeper understanding of the impact of prenatal tobacco exposure on lung health, laying the groundwork for the development of relevant prevention and treatment strategies.

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Section: Principal Findingsmentioning

confidence: 68%

Mediating Effect of Tobacco Dependence on the Association Between Maternal Smoking During Pregnancy and Chronic Obstructive Pulmonary Disease: Case-Control Study

Li,

Xu,

Yang

et al. 2024

JMIR Public Health Surveill

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“…The purpose of this series is to highlight the power of nonpharmacological interventions as well as to discuss their weaknesses and challenges. M ontes de O ca and L aucho- C ontreras [ 2 ] discuss the role of smoking cessation for primary and secondary prevention of COPD. We also hope to include a review of the evidence for vaccination in patients with COPD.…”

mentioning

confidence: 99%

Nonpharmacological interventions in COPD

Janssens

Verleden

2023

Eur Respir Rev

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COPD is recognised as one of the major health challenges for the coming decades. This is primarily driven by a growing burden of the disease due to persistent exposure to tobacco smoke and environmental pollutants, an ageing population, and no curative therapies to date. To change the disease course, to reduce its societal impact and eventually eliminate the disease, a recent Lancet commission paper made a plea for a complete rethinking of our current approach in COPD [1]. One of the six major challenges identified is the huge unmet need for a personalised approach based on a holistic assessment of pathophysiological traits, clinical symptoms and patients’ needs. Current pharmacological therapies may improve respiratory symptoms, quality of life and reduce exacerbation frequency, but the majority of COPD patients remain highly symptomatic despite optimised drug combinations and innovative inhalers.

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Heterogeneities and impact profiles of early chronic obstructive pulmonary disease status: findings from the China Pulmonary Health Study

Lei,

Huang,

et al. 2024

The Lancet Regional Health - Western Pacific

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Smoking cessation and vaccination

Cited by 6 publications

References 103 publications

Mediating Effect of Tobacco Dependence on the Association Between Maternal Smoking During Pregnancy and Chronic Obstructive Pulmonary Disease: Case-Control Study

Mediating Effect of Tobacco Dependence on the Association Between Maternal Smoking During Pregnancy and Chronic Obstructive Pulmonary Disease: Case-Control Study

Nonpharmacological interventions in COPD

Heterogeneities and impact profiles of early chronic obstructive pulmonary disease status: findings from the China Pulmonary Health Study

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