2000
DOI: 10.1164/ajrccm.161.2.9901044
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Smoking Cessation and Lung Function in Mild-to-Moderate Chronic Obstructive Pulmonary Disease

Abstract: Previous studies of lung function in relation to smoking cessation have not adequately quantified the long-term benefit of smoking cessation, nor established the predictive value of characteristics such as airway hyperresponsiveness. In a prospective randomized clinical trial at 10 North American medical centers, we studied 3, 926 smokers with mild-to-moderate airway obstruction (3,818 with analyzable results; mean age at entry, 48.5 yr; 36% women) randomized to one of two smoking cessation groups or to a noni… Show more

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Cited by 627 publications
(249 citation statements)
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“…The groups listed in Table 1 also have a disproportionate burden of tobacco-related disease compared with a general population of smokers, especially substance abusers who smoke and smokers with HIV/AIDS or medical comorbidities (Crothers et al, 2005;Hurt et al, 1996;Scanlon et al, 2000;Turner et al, 2001;Twardella, Rothenbacher, Hahmann, Wusten, & Brenner, 2006;Wilson, 2006). Many of the groups in Table 1 have less access to effective treatments or are less likely to receive advice to quit from health care practitioners, especially smokers with low socioeconomic status (SES), mobility-impaired smokers, and Native American smokers (Connor, Cook, Herbert, Neal, & Williams, 2002;Murphy, Mahoney, Hyland, Higbee, & Cummings, 2005;Reed & Burns, 2008).…”
Section: Smoking Prevalencementioning
confidence: 99%
“…The groups listed in Table 1 also have a disproportionate burden of tobacco-related disease compared with a general population of smokers, especially substance abusers who smoke and smokers with HIV/AIDS or medical comorbidities (Crothers et al, 2005;Hurt et al, 1996;Scanlon et al, 2000;Turner et al, 2001;Twardella, Rothenbacher, Hahmann, Wusten, & Brenner, 2006;Wilson, 2006). Many of the groups in Table 1 have less access to effective treatments or are less likely to receive advice to quit from health care practitioners, especially smokers with low socioeconomic status (SES), mobility-impaired smokers, and Native American smokers (Connor, Cook, Herbert, Neal, & Williams, 2002;Murphy, Mahoney, Hyland, Higbee, & Cummings, 2005;Reed & Burns, 2008).…”
Section: Smoking Prevalencementioning
confidence: 99%
“…18 FEV 1 is also vulnerable to the impact of smoking and ambient air pollution. 23,24 Therefore, the fixed ration of FEV 1 /FEV 6 for diagnosis of COPD also should be interpreted in the context of the patient's risk factors, age, and symptoms. However, the merit of using a fixed cutoff value for the FEV 1 /FEV 6 instead of a reference equation to diagnose COPD is still highlighted by the COPD guidelines.…”
Section: Discussionmentioning
confidence: 99%
“…The greater alleviation of asthma symptoms among non-smokers is understandable, since smoking directly affects asthmatic symptoms [5,6] and the development of COPD [14]. Tobacco smoke can also affect symptoms by altering the response to inhaled corticosteroids [15].…”
Section: Discussionmentioning
confidence: 99%